Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1, 2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 1845-1855

  Afonso, Adriano ^a   Weinstein, Jay ^a   Kelly, Joseph ^a   Wolin, Ronald ^a   Rosenblum, Stuart B ^a   Connolly, Michael ^a   Guzi, Timothy ^a   James, Linda ^a   Carr, Donna ^a   Patton, Robert ^a   Bishop, W Robert ^a   Kirshmeier, Paul ^a   Liu, M ^a   Heimark, L ^a   Chen, K J ^a   Nomeir, A A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YL)PIPERIDINE; PIPERIDINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; MOUSE; NONHUMAN; REACTION ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; PIPERIDINES; PYRIDINES; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032871198     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00103-0     Document Type: Article

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24. The structures of the regioisomers were assigned by NMR experiments. NOE was observed between the following resonances: in 6i, between 8-methyl and the 7-H and 9-H, and between the 10-methoxyl and 9-H resonances; in 6j between 8-methyl and the 7-H and 9-H; in 6k between the 10-methyl and 9-H; in N-methyl-9i between 9-H and 8-methyl and 10-methoxy, and between the 10-methoxyl and 9-H resonances.