Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

Arthritis Research and Therapy

Volumn 14, Issue 1, 2012, Pages

  Yin, Hongen ^a   Nguyen, Cuong Q ^b   Samuni, Yuval ^a   Uede, Toshimitsu ^c   Peck, Ammon B ^b   Chiorini, John A ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Adeno associated virus (AAV); CTLA4igG fusion protein; Prevention; Salivary gland dysfunction; Sj gren's syndrome

Indexed keywords

ABATACEPT; BETA GALACTOSIDASE; RECOMBINANT ADENO ASSOCIATED VIRUS 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIRUS VECTOR; ANTIBODY CONJUGATE; ANTINUCLEAR ANTIBODY; B7 ANTIGEN; CYTOKINE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; C57BL 6 MOUSE; CANNULATION; CELL INFILTRATION; CELL STRAIN HEK293; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SALIVARY GLAND FUNCTION; SIALOADENITIS; SJOEGREN SYNDROME; SUBMANDIBULAR GLAND; T LYMPHOCYTE; ADENO ASSOCIATED VIRUS; ANIMAL; BLOOD; C57BL MOUSE; DISEASE MODEL; DRUG DELIVERY SYSTEM; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; LACRIMAL APPARATUS; LYMPHOCYTE; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; SALIVARY GLAND; SALIVATION;

ANIMALS; ANTIBODIES, ANTINUCLEAR; B7 ANTIGENS; CYTOKINES; DENDRITIC CELLS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FEMALE; GENETIC VECTORS; HEK293 CELLS; HUMANS; IMMUNOCONJUGATES; LACRIMAL APPARATUS; LYMPHOCYTES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; SALIVARY GLANDS; SALIVATION; SIALADENITIS; SJOGREN'S SYNDROME; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84857425226     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3753     Document Type: Article

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