Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Miyazaki, Atsuko ^a   Yogosawa, Satomi ^a   Murakami, Akikazu ^a   Kitamura, Daisuke ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CELL SURFACE IMMUNOGLOBULIN; CLATHRIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BLNK; PROTEIN CMTM7; PROTEIN KINASE SYK; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; B CELL LINKER PROTEIN; CHEMOKINE; CMTM7 PROTEIN, HUMAN; CMTM7 PROTEIN, MOUSE; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PHOSPHORYLATION; PLASMID; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; HELA CELL; METABOLISM; MOUSE; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL MEMBRANE; CHEMOKINES; CLATHRIN; HELA CELLS; HUMANS; IMMUNOGLOBULIN M; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857400782     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031829     Document Type: Article

References (33)

1. Pierce SK, Liu W, (2010) The tipping points in the initiation of B cell signalling: how small changes make big differences. Nat Rev Immunol 11: 767-777.
2. Stoddart A, Dykstra ML, Brown BK, Song W, Pierce SK, et al. (2002) Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity 17: 451-462.
3. Reth M, Wienands J, (1997) Initiation and processing of signals from the B cell antigen receptor. Annu Rev Immunol pp. 15453-15479.
4. Kurosaki T, (2002) Regulation of B-cell signal transduction by adaptor proteins. Nat Rev Immunol 2: 354-363.
5. Oh-hora M, Johmura S, Hashimoto A, Hikida M, Kurosaki T, (2003) Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med 198: 1841-1851.
6. Kitamura D, (2007) Self-nonself recognition through B-cell antigen receptor. In: Kitamura D, editors. How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling Springer Tokyo pp. 99-132.
7. Jumaa H, Wollscheid B, Mitterer M, Wienands J, Reth M, et al. (1999) Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11: 547-554.
8. Pappu R, Cheng AM, Li B, Gong Q, Chiu C, et al. (1999) Requirement for B cell linker protein (BLNK) in B cell development. Science 286: 1949-1954.
9. Xu S, Tan JE, Wong EP, Manickam A, Ponniah S, et al. (2000) B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int Immunol 12: 397-404.
10. Hayashi K, Nittono R, Okamoto N, Tsuji S, Hara Y, et al. (2000) The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc Natl Acad Sci U S A 97: 2755-2760.
11. Hayashi K, Yamamoto M, Nojima T, Goitsuka R, Kitamura D, (2003) Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity 18: 825-836.
12. Ishiai M, Kurosaki M, Pappu R, Okawa K, Ronko I, et al. (1999) BLNK required for coupling Syk to PLCg2 and Rac1-JNK in B cells. Immunity 10: 117-125.
13. Tan JE, Wong SC, Gan SK, Xu S, Lam KP, (2001) The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes. J Biol Chem 276: 20055-20063.
14. Engels N, Wollscheid B, Wienands J, (2001) Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha. Eur J Immunol 31: 2126-2134.
15. Kabak S, Skaggs BJ, Gold MR, Affolter M, West KL, et al. (2002) The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol 22: 2524-2535.
16. Siemasko K, Skaggs BJ, Kabak S, Williamson E, Brown BK, et al. (2002) Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. J Immunol 168: 2127-2138.
17. Pike KA, Ratcliffe MJ, (2005) Dual requirement for the Ig alpha immunoreceptor tyrosine-based activation motif (ITAM) and a conserved non-Ig alpha ITAM tyrosine in supporting Ig alpha beta-mediated B cell development. J Immunol 174: 2012-2020.
18. Patterson HC, Kraus M, Kim YM, Ploegh H, Rajewsky K, (2006) The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity 25: 55-65.
19. Goitsuka R, Fujimura Y, Mamada H, Umeda A, Morimura T, et al. (1998) BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. J Immunol 161: 5804-5808.
20. Abudula A, Grabbe A, Brechmann M, Polaschegg C, Herrmann N, et al. (2007) SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk. J Biol Chem 282: 29059-29066.
21. Kulathu Y, Hobeika E, Turchinovich G, Reth M, (2008) The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J 27: 1333-1344.
22. Köhler F, Storch B, Kulathu Y, Herzog S, Kuppig S, et al. (2005) A leucine zipper in the N terminus confers membrane association to SLP-65. Nat Immunol 6: 204-210.
23. Imamura Y, Katahira T, Kitamura D, (2004) Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. J Biol Chem 279: 26425-26432.
24. Han W, Ding P, Xu M, Wang L, Rui M, et al. (2003) Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics 81: 609-617.
25. Sánchez-Pulido L, Martín-Belmonte F, Valencia A, Alonso MA, (2002) MARVEL: a conserved domain involved in membrane apposition events. Trends Biochem Sci 27: 599-601.
26. Fu C, Turck CW, Kurosaki T, Chan AC, (1998) BLNK: a central linker protein in B cell activation. Immunity 9: 93-103.
27. Tolar P, Hanna J, Krueger PD, Pierce SK, (2009) The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Immunity 30: 44-55.
28. Kim JH, Cramer L, Mueller H, Wilson B, Vilen BJ, (2005) Independent trafficking of Ig-alpha/Ig-beta and mu-heavy chain is facilitated by dissociation of the B cell antigen receptor complex. J Immunol 175: 147-154.
29. Kremyanskaya M, Monroe JG, (2005) Ig-independent Ig beta expression on the surface of B lymphocytes after B cell receptor aggregation. J Immunol 174: 1501-1506.
30. Kim KJ, Kanellopoulos-Langevin C, Merwin RM, Sachs DH, Asofsky R, (1979) Establishment and characterization of BALB/c lymphoma lines with B cell properties. J Immunol 122: 549-554.
31. Scherer WF, Syverton JT, Gey GO, (1953) Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix. J Exp Med 97: 695-710.
32. DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, et al. (1987) Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol Cel Biol 7: 379-387.
33. Oda A, Ono T, Yamamoto M, Goitsuka R, Kitamura D, (2008) PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway. Int Immunol 20: 1417-1426.