PKCη directs induction of IRF-4 expression and Ig κ gene rearrangement in pre-BCR signaling pathway

International Immunology

Volumn 20, Issue 11, 2008, Pages 1417-1426

  Oda, Akihisa ^a   Ono, Tomohiro ^a   Yamamoto, Mutsumi ^a,b   Goitsuka, Ryo ^a   Kitamura, Daisuke ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

BLNK; Ig gene; Pre B cell; Pre B cell receptor; Protein kinase C; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN B CELL LINKER; B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN KAPPA CHAIN; INTERFERON REGULATORY FACTOR 4; PHOSPHOLIPASE C; PROTEIN KINASE C ETA; REAGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EX VIVO STUDY; GENE EXPRESSION; GENE REARRANGEMENT; GENE SILENCING; IMMUNOGLOBULIN LIGHT CHAIN GENE; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DOWN-REGULATION; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; IMMUNOGLOBULIN MU-CHAINS; INTERFERON REGULATORY FACTORS; MICE; PRECURSOR CELLS, B-LYMPHOID; PROTEIN KINASE C; RECEPTOR AGGREGATION; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 54949095847     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxn101     Document Type: Article

References (38)

1. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
2. Karasuyama, H., Rolink, A. and Melchers, F. 1996. Surrogate light chain in B cell development. Adv. Immunol. 63:1.
3. Kurosaki, T 2002. Regulation of B cell fates by BCR signaling components. Curr. Opin. Immunol. 14:341.
4. Guo, B., Kato, R. M., Garcia-Lloret, M., Wahl, M. I. and Rawlings, D. J. 2000. Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity 13:243.
5. Jumaa, H., Wollscheid, B., Mitterer, M., Wienands, J., Reth, M. and Nielsen, P. J. 1999. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11:547.
6. Pappu, R., Cheng, A. M., Li, B. et al. 1999. Requirement for B cell linker protein (BLNK) in B cell development. Science 286:1949.
7. Hayashi, K., Nittono, R., Okamoto, N. et al. 2000. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl Acad. Sci. USA 97:2755.
8. Xu, S. L., Tan, J. E. L., Wong, E. P. Y., Manickam, A., Ponniah, S. and Lam, K. P. 2000. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int. Immunol. 12:397.
9. Hayashi, K., Yamamoto, M., Nojima, T., Goitsuka, R. and Kitamura, D. 2003. Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity 18:825.
10. Flemming, A., Brummer, T., Reth, M. and Jumaa, H. 2003. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat. Immunol 4:38.
11. Khan, W. N., Alt, F. W., Gerstein, R. M. et al. 1995. Defective B cell development and function in Btk-deficient mice. Immunity 3:283.
12. Wang, D., Feng, J., Wen, R. et al. 2000. Phospholipase C-gamma 2 is essential in the functions of B cell and several Fc receptors. Immunity 13:25.
13. Hashimoto, A., Takeda, K., Inaba, M. et al. 2000. Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J. Immunol 165:1738.
14. Jumaa, H., Mitterer, M., Reth, M. and Nielsen, P. J. 2001. The absence of SLP65 and Btlk blocks B cell development at the pre-B cell receptor-positive stage. Eur. J. Immunol 31:2164.
15. Xu, S., Huo, J., Chew, W. K., Hikida, M., Kurosaki, T. and Lam, K. P. 2006. Phospholipase C-gamma 2 dosage is critical for B cell development in the absence of adaptor protein BLNK. J. Immunol 176:4690.
16. Xu, S., Lee, K. G., Huo, J., Kurosaki, T. and Lam, K. P. 2007. Combined deficiencies in Bruton tyrosine kinase and phospholipase C-gamma 2 arrest B-cell development at a pre-BCR+ stage. Blood 109:3377.
17. Kersseboom, R., Middendorp, S., Dingjan, G. M. et al. 2003. Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J. Exp. Med. 198:91.
18. Su, Y. W. and Jumaa, H. 2003. LAT links the pre-BCR to calcium signaling. Immunity 19:295.
19. Kersseboom, R., Ta, V. B. T., Zijlstra, A. J. E. et al. 2006. Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement. J. Immunol 176:4543.
20. Muljo, S. A. and Schlissel, M. S. 2003. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol 4:31.
21. Pongubala, J. M. R., Nagulapalli, S., Klemsz, M. J., Mckercher, S. R., Maki, R. and Atchison, M. L. 1992. Pu-1 recruits a second nuclear factor to a site important for immunoglobulin-kappa-3′ enhancer activity. Mol. Cell. Biol. 12:368.
22. Eisenbeis, C. F., Singh, H. and Storb, U. 1995. Pip, a novel Irf family member, is a lymphoid-specific, Pu.1-dependent transcriptional activator. Genes. Dev. 9:1377.
23. Brass, A. L., Zhu, A. Q. and Singh, H. 1999. Assembly requirements of PU.1-Pip (IRF-4) activator complexes: Inhibiting function in vivo using fused dimers. EMBO J. 18:977.
24. Lu, R., Medina, K. L., Lancki, D. W. and Singh, H. 2003. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 17:1703.
25. Inlay, M., Alt, F. W., Baltimore, D. and Xu, Y. 2002. Essential roles of the kappa light chain intronic enhancer and 3′ enhancer in kappa rearrangement and demethylation. Nat. Immunol. 3:463.
26. Ma, S., Turetsky, A., Trinh, L. and Lu, R. 2006. IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. J. Immunol. 177:7898.
27. Johnson, K., Hashimshony, T, Sawai, C. M. et al. 2008. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity 28:335.
28. Thompson, E. C., Cobb, B. S., Sabbattini, P. et al. 2007. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity 26:335.
29. Yamamoto, M., Hayashi, K., Nojima, T. et al. 2006. BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood 108:2703.
30. Swift, S., Lorens, J., Achacoso, P. and Nolan, G. P. 2001. Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems. in Coligan, J. E. et al., ed., Curr. Protoc. Immunol. Chapter 10: Unit 10.17C. John Wiley and Sons. Inc., New Jersey.
31. Bankovich, A. J., Raunser, S., Juo, Z. S., Walz, T., Davis, M. M. and Garcia, K. C. 2007. Structural insight into pre-B cell receptor function. Science 316:291.
32. Ohnishi, K. and Melchers, F. 2003. The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling. Nat. Immunol. 4:849.
33. Engels, N., Wollscheid, B. and Wienands, J. 2001. Association of SLP-65/ BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha. Eur. J. Immunol. 31:2126.
34. Kohler, F., Storch, B., Kulathu, Y. et al. 2005. A leucine zipper in the N terminus confers membrane association to SLP-65. Nat. Immunol. 6:204.
35. Imamura, Y., Katahira, T. and Kitamura, D. 2004. Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. J. Biol. Chem. 279:26425.
36. Kawano, Y., Yoshikawa, S., Minegishi, Y. and Karasuyama, H. 2006. Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J. Immunol. 177:2242.
37. Herzog, S., Hug, E., Meixlsperger, S. et al. 2008. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat. Immunol. 9:623.
38. Liu, H., Qiu, Y. L., Xiao, L. and Dong, F. 2006. Involvement of protein kinase Cε in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor. J. Immunol. 176:2407.