Occurrence of pharmaceutical compounds in wastewater process streams in Dublin, Ireland

Environmental Monitoring and Assessment

Volumn 184, Issue 2, 2012, Pages 1049-1062

  Lacey, Clair ^a   Basha, Shaik ^a,b   Morrissey, Anne ^a   Tobin, John M ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b CSIR CENTRAL SALT AND MARINE CHEMICALS RESEARCH INSTITUTE   (India)

Author keywords

Ireland; Pharmaceuticals; Removal efficiency; Wastewater; WWTP

Indexed keywords

AQUATIC SPECIES; CARBAMAZEPINE; DICLOFENAC; ECOTOXICOLOGICAL EFFECTS; EFFLUENT CONCENTRATIONS; EXPOSURE CONCENTRATION; FUROSEMIDES; GEMFIBROZILS; IRELAND; MEFENAMIC ACID; MEMBRANE FILTRATIONS; METOPROLOL; NIMESULIDE; ON CURRENTS; PHARMACEUTICAL COMPOUNDS; PREDICTED NO-EFFECT CONCENTRATIONS; PROCESS STREAMS; REMOVAL EFFICIENCIES; REMOVAL EFFICIENCY; SEASONAL VARIABILITY; SOLID-PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; WASTEWATER TREATMENT PLANTS; WWTP;

AMIDES; DRUG PRODUCTS; EFFLUENTS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROFILTRATION; TOXICITY; WASTEWATER;

ANTIBIOTICS;

ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIFUNGAL AGENT; ANTIINFLAMMATORY AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CLOTRIMAZOLE; DICLOFENAC; DRUG; FUROSEMIDE; GEMFIBROZIL; MEFENAMIC ACID; METOPROLOL; NIMESULIDE; PROPRANOLOL;

ANTIBIOTICS; CONCENTRATION (COMPOSITION); DRUG; ECOTOXICOLOGY; EFFLUENT; TOXICITY; WASTEWATER;

ARTICLE; CONTROLLED STUDY; ECOTOXICOLOGY; EFFLUENT; IRELAND; LIQUID CHROMATOGRAPHY; MEMBRANE FILTER; SAMPLE; SEASONAL VARIATION; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; WASTE COMPONENT REMOVAL; WASTE WATER TREATMENT PLANT;

ANTI-BACTERIAL AGENTS; CITIES; ENVIRONMENTAL MONITORING; IRELAND; PHARMACEUTICAL PREPARATIONS; SEASONS; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL; WATER POLLUTION, CHEMICAL;

COUNTY DUBLIN; DUBLIN [COUNTY DUBLIN]; IRELAND; LEINSTER;

EID: 84857359932     PISSN: 01676369     EISSN: 15732959     Source Type: Journal    
DOI: 10.1007/s10661-011-2020-z     Document Type: Article

References (60)

1. Barry, M. (2008). Economies in drug usage in the Irish healthcare setting (pp. 1-34). Dublin: National Centre for Pharmacoeconomics. http://www.indi.ie/ docs/878-economies-drug-usage-(2).pdf.
2. AL Batt MS Kostich JM Lazorchak 2008 Analysis of ecologically relevant pharmaceuticals in wastewater and surface water using selective solid-phase extraction and UPLC-MS/MS Analytical Chemistry 80 5021 5030 1:CAS:528: DC%2BD1cXmt1Srtbk%3D
3. D Bendz NA Paxeus TR Ginn FJ Logec 2005 Occurrence and fate of pharmaceutically active compounds in the environment, a case study: Hoje River in Sweden Journal of Hazardous Materials 122 195 204 1:CAS:528: DC%2BD2MXlsVCrsrY%3D
4. a values of active pharmaceutical ingredients TrAC. Trends in Analytical Chemistry 26 1043 1061
5. J Bones K Thomas PN Nesterenko B Paull 2006 Dual gradient LC method for the determination of pharmaceutical residues in environmental samples using monolithic silica reversed phase column International Journal of Environmental Analytical Chemistry 86 487 504 1:CAS:528:DC%2BD28XktVGksr0%3D
6. J Bones K Thomas PN Nesterenko B Paull 2006 On-line preconcentration of pharmaceutical residues from large volume water samples using short reversed-phase monolithic cartridges coupled to LC-UV-ESI-MS Talanta 70 1117 1128 1:CAS:528:DC%2BD28XhtFyqur3O
7. JN Brown N Paxeus L Forlin DG Joakim Larsson 2007 Variation in the bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma Environmental Toxicology of Pharmaceuticals 24 267 274 1:CAS:528:DC%2BD2sXhtFSlsrzO
8. S Castiglioni R Bagnati R Fanelli F Pomati D Calamari E Zuccato 2006 Removal of pharmaceuticals in sewage treatment plants in Italy Environmental Science and Technology 40 357 363 1:CAS:528:DC%2BD2MXht1Gju7jE
9. M Clara B Strenn N Kreuzinger 2004 Carbamazepine as a possible anthropogenic marker in the aquatic environment: Investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration Water Research 38 947 954 1:CAS:528:DC%2BD2cXhtVehtrw%3D
10. M Clara N Kruzinger B Strenn O Gans H Kroiss 2005 The solids retention time-A suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants Water Research 39 97 106 1:CAS:528:DC%2BD2cXhtVOitbvF
11. M Cleuvers 2003 Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects Toxicology Letters 142 185 194 1:CAS:528:DC%2BD3sXis12lsb4%3D
12. M Crane C Watts T Boucard 2006 Chronic aquatic environmental risks from exposure to human pharmaceuticals Science of the Total Environment 367 23 41 1:CAS:528:DC%2BD28Xnt1yhtLw%3D
13. CG Daughton TA Ternes 1999 Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environmental Health Perspectives 107 907 938 1:CAS:528:DC%2BD3cXos1OhtA%3D%3D
14. a Determination of nimesulide in methanol-water mixtures by potentiometric titrations International Journal of Pharmaceuticals 158 109 112 1:CAS:528:DyaK2sXotVOhtbs%3D
15. K Fent AA Weston D Caminada 2006 Ecotoxicology of human pharmaceuticals Aquatic Toxicology 76 122 159 1:CAS:528:DC%2BD28Xjsl2qtQ%3D%3D
16. B Ferrari N Paxeus R Lo Giudice A Pollio J Garric 2003 Ecotoxicological impact of pharmaceuticals found in treated wastewaters: Study of carbamazepine, clofibric acid and diclofenac Ecotoxicology and Environmental Safety 55 359 370 1:CAS:528:DC%2BD3sXksVyrtr0%3D
17. CM Flaherty SI Dodson 2005 Effects of pharmaceuticals on Daphnia survival, growth, and reproduction Chemosphere 61 200 207 1:CAS:528: DC%2BD2MXhtVWns7vE
18. B Forbes A Shah GP Martin AB Lansley 2003 The human bronchial epithelial cell line 16HBE14o-As a model system of the airways for studying drug transport International Journal of Pharmaceuticals 257 161 167 1:CAS:528: DC%2BD3sXjtVemsrc%3D
19. E Gracia-Lor JV Sancho F Hernandez 2010 Simultaneous determination of acidic, neutral and basic pharmaceuticals in urban wastewater by ultra high-pressure liquid chromatography-tandem mass spectrometry Journal of Chromatography A 1217 622 632 1:CAS:528:DC%2BC3cXkt1Ohug%3D%3D
20. Health Service Executive (2005). Statistical analysis of claims and payments. http://www.hse.ie/eng/Staff/PCRS/PCRS-Publications/Primary-Care- Reimbursement-Service-Financial-and-Statistical-Analysis-2005.pdf
21. T Heberer 2002 Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data Toxicology Letters 131 5 17 1:CAS:528:DC%2BD38Xjt1Wju7s%3D
22. T Heberer M Adam 2004 Transport and attenuation of pharmaceutical residues during artificial groundwater replenishment Environmental Chemistry 1 22 25 1:CAS:528:DC%2BD2cXntlGiu7Y%3D
23. HN Hong HN Kim KS Park S Lee MB Gu 2007 Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using real-time PCR Chemosphere 67 2115 2121 1:CAS:528:DC%2BD2sXjsVGjtL8%3D
24. ThEM Hulscher G Cornelissen 1996 Effect of temperature on sorption equilibrium and sorption kinetics of organic micropollutants-A review Chemosphere 32 609 626
25. Irish Medicines Board (IMB) (2010). www.imb.ie. Accessed on 02 Sep 2010.
26. M Isidori A Nardelli A Parrella L Pascarella L Previtera 2006 A multispecies study to assess the toxic and genotoxic effect of pharmaceuticals: Furosemide and its photoproduct Chemosphere 63 785 793 1:CAS:528: DC%2BD28XjvFWgtLw%3D
27. TL Jones-Lepp R Stevens 2007 Pharmaceuticals and personal care products in biosolids/sewage sludge: The interface between analytical chemistry and regulation Analytical and Bioanalytical Chemistry 387 1173 1183 1:CAS:528:DC%2BD2sXhsFWlsL8%3D
28. OAH Jones N Voulvoulis JN Lester 2002 Aquatic environmental assessment of the top 25 English prescription pharmaceuticals Water Research 36 5013 5022 1:CAS:528:DC%2BD38XnvVekt7k%3D
29. M Kahle IJ Buerge A Hauser MD Mller T Poiger 2008 Azole fungicides: Occurrence and fate in wastewater and surface waters Environmental Science and Technology 42 7193 7200 1:CAS:528:DC%2BD1cXhtVems77L
30. B Kasprzyk-Hordern RM Dinsdale AJ Guwy 2008 Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry Analytical and Bioanalytical Chemistry 391 1293 1308 1:CAS:528:DC%2BD1cXmsVeht7k%3D
31. SK Khetan TJ Collins 2007 Human pharmaceuticals in the aquatic environment: A challenge to green chemistry Chemical Reviews 107 2319 2364 1:CAS:528:DC%2BD2sXlvVelsrg%3D
32. K Kimura H Hara Y Watanabe 2007 Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors Environmental Science and Technology 41 3708 3714 1:CAS:528:DC%2BD2sXkt1Shs74%3D
33. D Kobayashi T Nozawa K Imai J-I Nezu A Tsuji I Tamai 2003 Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane Journal of Pharmacology and Experimental Therapeutics 306 703 708 1:CAS:528:DC%2BD3sXlslGlu70%3D
34. T Kubota K Fujisaki Y Itoh T Yano T Sendo R Oishi 2004 Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors Biochemical Pharmacology 67 2175 2186 1:CAS:528:DC%2BD2cXkt1Sktbk%3D
35. Kummerer, K. (Ed.) (2004). Pharmaceuticals in the environment-sources, fate, effects and risks (2nd ed.). Berlin: Springer.
36. C Lacey G McMahon J Bones L Barron A Morrissey J Tobin 2008 An LC-MS method for the determination of pharmaceutical compounds in wastewater treatment plant influent and effluent samples Talanta 75 1089 1097 1:CAS:528: DC%2BD1cXlvVOjsbo%3D
37. JL Maggs M Pirmohamed NR Kitteringham BK Park 1997 Characteristics of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry Drug Metabolites and Disposal 25 275 280 1:CAS:528: DyaK2sXhvFensLo%3D
38. X-S Miao CD Metcalfe 2003 Determination of cholesterol-lowering statin drugs in aqueous samples using liquid chromatography-electrospray ionization tandem mass spectrometry Journal of Chromatography A 998 133 141 1:CAS:528:DC%2BD3sXkt1yisb0%3D
39. X-S Miao J-J Yang CD Metcalfe 2005 Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant Environmental Science and Technology 39 7469 7475 1:CAS:528:DC%2BD2MXpslWkt70%3D
40. A Nikolaou S Meric D Fatta 2007 Occurrence patterns of pharmaceuticals in water and wastewater environments Analytical and Bioanalytical Chemistry 387 1225 1234 1:CAS:528:DC%2BD2sXhsFWlsbc%3D
41. J Oaks M Gilbert M Virani R Watson C Meteyer B Rideout, et al. 2004 Diclofenac residues as the cause of vulture population decline in Pakistan Nature 427 630 633 1:CAS:528:DC%2BD2cXhtFCnu7o%3D
42. OSPAR Commission (2005). Open access document on clotrimazole. Publication no. 2005/199.
43. PH Roberts KV Thomas 2006 The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment Science of the Total Environment 356 143 153 1:CAS:528:DC%2BD28Xhs1yqtLY%3D
44. JA Ruell O Tsinman A Avdeef 2004 Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules Chemical and Pharmaceutical Bulletin 52 561 565 1:CAS:528:DC%2BD2cXksVyltLo%3D
45. JL Santos I Aparicio E Alonso 2007 Occurrence risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain) Environment International 33 596 601 1:CAS:528: DC%2BD2sXjvFOlu78%3D
46. JL Santos I Aparicio M Callejón E Alonso 2009 Occurrence of pharmaceutically active compounds during 1-year period in wastewaters from four wastewater treatment plants in Seville (Spain) Journal of Hazardous Materials 164 1509 1516 1:CAS:528:DC%2BD1MXjsVCksr8%3D
47. T Scheytt P Mersmann R Lindstadt T Herberer 2005 Determination of sorption coefficients of pharmaceutically active substances carbamazepine, diclofenac, and ibuprofen, in sandy sediments Chemosphere 60 245 253 1:CAS:528:DC%2BD2MXks1CqsLc%3D
48. T Scheytt P Mersmann R Lindstadt T Herberer 2005 1-Octanol/water partition coefficients of 5 pharmaceuticals from human medicinal care: Carbamazepine, clofibric acid, diclofenac, ibuprofen and propyphenazone Water Air Soil Pollution 165 3 11 1:CAS:528:DC%2BD2MXntleisLY%3D
49. AL Spongberg JD Witter 2008 Pharmaceutical compounds in the wastewater process stream in Northwest Ohio Science of the Total Environment 397 148 157 1:CAS:528:DC%2BD1cXlvVSltr8%3D
50. M Stumpf TA Ternes RD Wilken SW Rodrigues W Baumann 1999 Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil Science of the Total Environment 225 135 141
51. TA Ternes 1998 Occurrence of drugs in German sewage treatment plants and rivers Water Research 32 3245 3260 1:CAS:528:DyaK1cXmslaqt7k%3D
52. TA Ternes N Herrmann M Bonerz T Knacker H Siegrist A Joss 2004 A rapid method to measure the solid-water distribution coefficient (Kd) for pharmaceuticals and musk fragrances in sewage sludge Water Research 38 4075 4084 1:CAS:528:DC%2BD2cXosFSmu74%3D
53. R Triebskorn H Casper V Scheil J Schwaiger 2007 Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchusmykiss) and common carp (Cyprinus carpio) Analytical and Bioanalytical Chemistry 387 1405 1416 1:CAS:528:DC%2BD2sXhsFWltr0%3D
54. B Tubic B Ivkovic M Zecevic S Vladimirov 2007 Simultaneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography Acta Chimica Slovenica 54 583 590 1:CAS:528:DC%2BD2sXht1WnsbrK
55. T Urase T Kikuta 2005 Separate estimation of adsorption and degradation pf pharmaceutical substances and estrogens in the activated sludge process Water Research 39 1289 1300 1:CAS:528:DC%2BD2MXjvVCltbc%3D
56. NM Vieno T Tuhkanen L Kronberg 2005 Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water Environmental Science and Technology 39 8220 8226 1:CAS:528:DC%2BD2MXhtVKhtbjJ
57. H Wulff GA Gutman MD Cahalan K Chandy 2001 Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1 Journal of Biological Chemistry 276 32040 32045 1:CAS:528:DC%2BD3MXms1Smt7o%3D
58. Y Yamini CT Reimann A Vatanara J Jonsson 2006 Extraction and preconcentration of salbutamol and terbutaline from aqueous samples using hollo fibre supported liquid membrane containing anionic carrier Journal of Chromatography A 1124 57 67 1:CAS:528:DC%2BD28Xns12nsbY%3D
59. Z Zhang A Hibberd JL Zhou 2008 Analysis of emerging contaminants in sewage effluent and riverwater: Comparison between spot and passive sampling Analytica Chimica Acta 607 37 44 1:CAS:528:DC%2BD2sXhsVKgtbjL
60. JL Zhou ZL Zhang E Banks D Grover JQ Jiang 2009 Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water Journal of Hazardous Materials 166 655 661 1:CAS:528:DC%2BD1MXlvFKisr8%3D