Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein

Mammalian Genome

Volumn 23, Issue 1-2, 2012, Pages 76-84

  Van Steenbeek, Frank G ^a   Van Den Bossche, Lindsay ^a   Leegwater, Peter A J ^a   Rothuizen, Jan ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREED DIFFERENCE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL PORTOSYSTEMIC SHUNT; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DOG; DUCTUS VENOSUS; ECHOGRAPHY; EMBRYO DEVELOPMENT; EXTRAHEPATIC PORTOSYSTEMIC SHUNT; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HERITABILITY; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; INTRAHEPATIC PORTOSYSTEMIC SHUNT; LABORATORY TEST; LIVER DYSFUNCTION; LIVER REGENERATION; MOLECULAR GENETICS; NONHUMAN; PEDIGREE ANALYSIS; PHENOTYPE; PORTAL VEIN BLOOD FLOW; PORTAL VEIN DISEASE; SIGNAL TRANSDUCTION; SPLANCHNIC BLOOD FLOW; VASCULAR PATENCY; VEIN DISEASE;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; DOG DISEASES; DOGS; EMBRYONIC DEVELOPMENT; FEMALE; LIVER; LIVER CIRCULATION; MALE; MICE; PHENOTYPE; PORTAL VEIN; RECEPTORS, ARYL HYDROCARBON;

CANIS FAMILIARIS;

EID: 84857358734     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-011-9364-0     Document Type: Article

References (88)

1. J Abernethy 1793 Account of two instances of uncommon formation in the viscera of the human body Philos Trans R Soc Lond B Biol Sci 83 295 299
2. AS Adeagbo CA Breen E Cutz JG Lees PM Olley F Coceani 1990 Lamb ductus venosus: evidence of a cytochrome P-450 mechanism in its contractile tension J Pharmacol Exp Ther 252 875 879 2313604 1:CAS:528:DyaK3cXhslKjtb8%3D
3. S Ali AH Stolpen WN Schmidt 2010 Portosystemic encephalopathy due to mesoiliac shunt in a patient without cirrhosis J Clin Gastroenterol 44 381 383 19636259
4. L Allen D Stobie GN Mauldin KE Baer 1999 Clinicopathologic features of dogs with hepatic microvascular dysplasia with and without portosystemic shunts: 42 cases (1991-1996) J Am Vet Med Assoc 214 218 220 9926012 1:STN:280:DyaK1M7isVygtw%3D%3D
5. E Alonso-Gamarra M Parron A Perez C Prieto L Hierro M Lopez-Santamaria 2011 Clinical and radiologic manifestations of congenital extrahepatic portosystemic shunts: a comprehensive review Radiographics 31 707 722 21571652 10.1148/rg.313105070
6. S Baade H Aupperle V Grevel HA Schoon 2006 Histopathological and immunohistochemical investigations of hepatic lesions associated with congenital portosystemic shunt in dogs J Comp Pathol 134 80 90 16423574 10.1016/j.jcpa.2005.07.003 1:CAS:528:DC%2BD28XmsFSmsA%3D%3D
7. B Baragatti E Ciofini F Scebba D Angeloni D Sodini S Luin GM Ratto V Ottaviano E Pagni A Paolicchi S Nencioni F Coceani 2011 Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice Am J Physiol Heart Circ Physiol 300 H892 H901 21193583 10.1152/ajpheart.00907. 2010 1:CAS:528:DC%2BC3MXjs1Gqsr8%3D
8. G Bertolini 2010 Acquired portal collateral circulation in the dog and cat Vet Radiol Ultrasound 51 25 33 20166389 10.1111/j.1740-8261.2009.01616.x
9. V Calvaruso S Maimone A Gatt E Tuddenham M Thursz M Pinzani AK Burroughs 2008 Coagulation and fibrosis in chronic liver disease Gut 57 1722 1727 19022928 10.1136/gut.2008.150748 1:STN:280:DC%2BD1cjlsVWltA%3D%3D
10. S Caruso S Riva M Spada A Luca B Gridelli 2010 Congenital extrahepatic portosystemic shunts (CEPS) type Ib: MDCT finding Dig Liver Dis 42 593 19357002 10.1016/j.dld.2009.02.053
11. Cullen JM, van den Ingh TSGAM, Bunch SE, Rothuizen J, Washabau RJ, Desmet VJ (2006) WSAVA Standards for clinical and histological diagnosis. WSAVA Liver Disease Standardization Group, St. Louis, pp 41-59
12. N Fausto 2004 Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells Hepatology 39 1477 1487 15185286 10.1002/hep.20214
13. RP Favier V Szatmari J Rothuizen 2004 Multiple congenital portal vein anomalies in a dog Vet Rec 154 604 605 15160849 10.1136/vr.154.19.604 1:STN:280:DC%2BD2c3mtFymsQ%3D%3D
14. M Fernandez D Semela J Bruix I Colle M Pinzani J Bosch 2009 Angiogenesis in liver disease J Hepatol 50 604 620 19157625 10.1016/j.jhep.2008.12.011 1:CAS:528:DC%2BD1MXhs1ekt7g%3D
15. GB Ferrero F Porta E Biamino A Mussa E Garelli F Chiappe A Veltri MC Silengo F Gennari 2010 Remittent hyperammonemia in congenital portosystemic shunt Eur J Pediatr 169 369 372 19618212 10.1007/s00431-009-1031-z
16. S Franchi-Abella S Branchereau V Lambert M Fabre C Steimberg J Losay JY Riou D Pariente F Gauthier E Jacquemin O Bernard 2010 Complications of congenital portosystemic shunts in children: therapeutic options and outcomes J Pediatr Gastroenterol Nutr 51 322 330 20601902
17. MJ Gerritzen-Bruning TS van den Ingh J Rothuizen 2006 Diagnostic value of fasting plasma ammonia and bile acid concentrations in the identification of portosystemic shunting in dogs J Vet Intern Med 20 13 19 16496918 10.1111/j.1939-1676.2006.tb02818.x 1:STN:280:DC%2BD287htVKhtg%3D%3D
18. D Hartmann U Srivastava M Thaler KN Kleinhans G N'kontchou A Scheffold K Bauer RF Kratzer N Kloos SF Katz Z Song Y Begus-Nahrmann A Kleger G von Figura P Strnad A Lechel C Gunes A Potthoff K Deterding H Wedemeyer Z Ju G Song F Xiao S Gillen H Schrezenmeier T Mertens M Ziol H Friess M Jarek MP Manns M Beaugrand KL Rudolph 2011 Telomerase gene mutations are associated with cirrhosis formation Hepatology 53 1608 1617 21520174 10.1002/hep.24217 1:CAS:528:DC%2BC3MXltVygurg%3D
19. GB Hunt 2004 Effect of breed on anatomy of portosystemic shunts resulting from congenital diseases in dogs and cats: a review of 242 cases Aust Vet J 82 746 749 15648933 10.1111/j.1751-0813.2004.tb13233.x 1:STN:280: DC%2BD2M%2Fit1KhtQ%3D%3D
20. J Ijzer BA Schotanus S Vander Borght TA Roskams R Kisjes LC Penning J Rothuizen TS van den Ingh 2010 Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: an immunohistochemical comparison between dog and man Vet J 184 308 314 19369099 10.1016/j.tvjl.2009.02.016 1:CAS:528:DC%2BC3cXlsFSnu7k%3D
21. A Kamimatsuse Y Onitake N Kamei G Tajima N Sakura T Sueda E Hiyama 2010 Surgical intervention for patent ductus venosus Pediatr Surg Int 26 1025 1030 20661579 10.1007/s00383-010-2662-x
22. MG Kerr T van Doorn 1999 Mass screening of Irish wolfhound puppies for portosystemic shunts by the dynamic bile acid test Vet Rec 144 693 696 10420483 10.1136/vr.144.25.693 1:STN:280:DyaK1MzkvV2lug%3D%3D
23. N Kobayashi T Niwa H Kirikoshi K Fujita M Yoneda S Saito A Nakajima 2010 Clinical classification of congenital extrahepatic portosystemic shunts Hepatol Res 40 585 593 20618456 10.1111/j.1872-034X.2010.00667.x
24. AA Konstas SR Digumarthy LL Avery KL Wallace M Lisovsky J Misdraji PF Hahn 2010 Congenital portosystemic shunts: Imaging findings and clinical presentations in 11 patients Eur J Radiol 80 2 175 181 20106622 10.1016/j.ejrad.2009.12.031
25. U Krotscheck CA Adin GB Hunt AE Kyles HN Erb 2007 Epidemiologic factors associated with the anatomic location of intrahepatic portosystemic shunts in dogs Vet Surg 36 31 36 17214817 10.1111/j.1532-950X.2007.00240.x
26. A Kummeling FJ Van Sluijs J Rothuizen 2004 Prognostic implications of the degree of shunt narrowing and of the portal vein diameter in dogs with congenital portosystemic shunts Vet Surg 33 17 24 14687182 10.1111/j.1532-950x. 2004.04004.x
27. GP Lahvis SL Lindell RS Thomas RS McCuskey C Murphy E Glover M Bentz J Southard CA Bradfield 2000 Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice Proc Natl Acad Sci USA 97 10442 10447 10973493 10.1073/pnas.190256997 1:CAS:528:DC%2BD3cXms1Crsbw%3D
28. CR Lamb CA Burton 2004 Doppler ultrasonographic assessment of closure of the ductus venosus in neonatal Irish wolfhounds Vet Rec 155 699 701 15605536 10.1136/vr.155.22.699 1:STN:280:DC%2BD2cnjtVahuw%3D%3D
29. CR Lamb RN White 1998 Morphology of congenital intrahepatic portacaval shunts in dogs and cats Vet Rec 142 55 60 9481840 10.1136/vr.142.3.55 1:STN:280:DyaK1c7kt1yguw%3D%3D
30. TB Lautz N Tantemsapya E Rowell RA Superina 2011 Management and classification of type II congenital portosystemic shunts J Pediatr Surg 46 308 314 21292079 10.1016/j.jpedsurg.2010.11.009
31. BC Lin LP Nguyen JA Walisser CA Bradfield 2008 A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse Mol Pharmacol 74 1367 1371 18669605 10.1124/mol.108.047068 1:CAS:528:DC%2BD1cXhtlCnt77M
32. M Lisovsky AA Konstas J Misdraji 2011 Congenital extrahepatic portosystemic shunts (Abernethy malformation): a histopathologic evaluation Am J Surg Pathol 35 1381 1390 21836489 10.1097/PAS.0b013e3182230ce4
33. CL Lohse PF Suter 1977 Functional closure of the ductus venosus during early postnatal life in the dog Am J Vet Res 38 839 844 560155 1:STN:280:DyaE2s3hvF2mtQ%3D%3D
34. JE Maddison 1992 Hepatic encephalopathy. Current concepts of the pathogenesis J Vet Intern Med 6 341 353 1362445 10.1111/j.1939-1676.1992. tb00367.x 1:STN:280:DyaK3s7jt1Onsg%3D%3D
35. E Maltepe JV Schmidt D Baunoch CA Bradfield MC Simon 1997 Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT Nature 386 403 407 9121557 10.1038/386403a0 1:CAS:528: DyaK2sXit1Wrtr8%3D
36. RA Martin 1993 Congenital portosystemic shunts in the dog and cat Vet Clin North Am Small Anim Pract 23 609 623 8503163 1:STN:280:DyaK3s3ns1GhtA%3D%3D
37. K Matsuzaki 2009 Modulation of TGF-beta signaling during progression of chronic liver diseases Front Biosci 14 2923 2934 19273245 10.2741/3423 1:CAS:528:DC%2BD1MXltlWhtbs%3D
38. HP Meyer J Rothuizen 1991 Congenital portosystemic shunts (PSS) in dogs are a genetic disorder Tijdschr Diergeneeskd 116 Suppl 1 80S 81S 2048089
39. HP Meyer J Rothuizen GJ Ubbink TS van den Ingh 1995 Increasing incidence of hereditary intrahepatic portosystemic shunts in Irish wolfhounds in The Netherlands (1984 to 1992) Vet Rec 136 13 16 7900255 10.1136/vr.136.1.13 1:STN:280:DyaK2M3gvVWrsQ%3D%3D
40. J Mimura Y Fujii-Kuriyama 2003 Functional role of AhR in the expression of toxic effects by TCDD Biochim Biophys Acta 1619 263 268 12573486 10.1016/S0304-4165(02)00485-3 1:CAS:528:DC%2BD3sXovFGrtg%3D%3D
41. E Minet D Mottet G Michel I Roland M Raes J Remacle C Michiels 1999 Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction FEBS Lett 460 251 256 10544245 10.1016/S0014-5793(99)01359-9 1:CAS:528: DyaK1MXmvFWnu7c%3D
42. CP Murray SJ Yoo PS Babyn 2003 Congenital extrahepatic portosystemic shunts Pediatr Radiol 33 614 620 12879313 10.1007/s00247-003-1002-x
43. T Nakajima M Moriguchi T Katagishi S Sekoguchi T Nishikawa H Takashima H Kimura M Minami Y Itoh K Kagawa Y Tani T Okanoue 2006 Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD Liver Int 26 23 31 16420506 10.1111/j.1478-3231.2005.01178.x 1:CAS:528:DC%2BD28XisFCmu74%3D
44. Nelson RW, Couto CG, King C, Ashby K (eds) (2005) Manual of small animal internal medicine. Elsevier Mosby, Philadelphia
45. B Newman JA Feinstein RA Cohen B Feingold J Kreutzer H Patel FP Chan 2010 Congenital extrahepatic portosystemic shunt associated with heterotaxy and polysplenia Pediatr Radiol 40 1222 1230 20069288 10.1007/s00247-009-1508-y
46. M Nukaya S Moran CA Bradfield 2009 The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology Proc Natl Acad Sci USA 106 12 4923 4928 19261855 10.1073/pnas.0809613106 1:CAS:528:DC%2BD1MXktFOjtbY%3D
47. M Nukaya BC Lin E Glover SM Moran GD Kennedy CA Bradfield 2010 The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes J Biol Chem 285 35599 35605 20829355 10.1074/jbc.M110.132043 1:CAS:528: DC%2BC3cXhtlyntLnO
48. M Nukaya JA Walisser SM Moran GD Kennedy CA Bradfield 2010 Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver Toxicol Sci 118 554 563 20935161 10.1093/toxsci/kfq305 1:CAS:528:DC%2BC3cXhsVKjsbbL
49. T Ohno J Muneuchi K Ihara T Yuge Y Kanaya S Yamaki T Hara 2008 Pulmonary hypertension in patients with congenital portosystemic venous shunt: a previously unrecognized association Pediatrics 121 e892 e899 18362102 10.1542/peds.2006-3411
50. JT Payne RA Martin GM Constantinescu 1990 The anatomy and embryology of portosystemic shunts in dogs and cats Semin Vet Med Surg (Small Anim) 5 76 82 1:STN:280:DyaK3czhvFKitA%3D%3D
51. GH Perdew 1988 Association of the Ah receptor with the 90-kDa heat shock protein J Biol Chem 263 13802 13805 2843537 1:CAS:528:DyaL1cXlvVGrs70%3D
52. AC Roman JM Carvajal-Gonzalez EM Rico-Leo PM Fernandez-Salguero 2009 Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma J Biol Chem 284 25135 25148 19617630 10.1074/jbc.M109.013292 1:CAS:528:DC%2BD1MXhtV2nsLfF
53. TA Roskams L Libbrecht VJ Desmet 2003 Progenitor cells in diseased human liver Semin Liver Dis 23 385 396 14722815 10.1055/s-2004-815564 1:CAS:528:DC%2BD2cXhtFWqtLnO
54. J Rothuizen TS van den Ingh 1982 Rectal ammonia tolerance test in the evaluation of portal circulation in dogs with liver disease Res Vet Sci 33 22 25 7134644 1:STN:280:DyaL3s%2FktVCquw%3D%3D
55. IA Schierz S La Placa M Giuffre G Montalbano M Lenzo G Corsello 2011 Transient hepatic nodular lesions associated with patent ductus venosus in preterm infants Am J Perinatol 28 177 180 20848372 10.1055/s-0030-1265829
56. BA Schotanus TS van den Ingh LC Penning J Rothuizen TA Roskams B Spee 2009 Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease Liver Int 29 1241 1252 19490419 10.1111/j.1478-3231.2009.02024.x
57. B Spee B Arends TS van den Ingh B Brinkhof H Nederbragt J Ijzer T Roskams LC Penning J Rothuizen 2006 Transforming growth factor beta-1 signalling in canine hepatic diseases: new models for human fibrotic liver pathologies Liver Int 26 716 725 16842329 10.1111/j.1478-3231.2006.01277.x 1:CAS:528: DC%2BD28XotVCms74%3D
58. B Spee B Arends TS van den Ingh T Roskams J Rothuizen LC Penning 2007 Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis Comp Hepatol 6 8 17672890 10.1186/1476-5926-6-8
59. B Spee G Carpino BA Schotanus A Katoonizadeh S Vander Borght E Gaudio T Roskams 2010 Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling Gut 59 247 257 19880964 10.1136/gut.2009.188367
60. A Sterczer HP Meyer HC Boswijk J Rothuizen 1999 Evaluation of ammonia measurements in dogs with two analysers for use in veterinary practice Vet Rec 144 523 526 10378279 10.1136/vr.144.19.523 1:STN:280:DyaK1Mzgs1SnsA%3D%3D
61. MD Stringer 2008 The clinical anatomy of congenital portosystemic venous shunts Clin Anat 21 147 157 18161055 10.1002/ca.20574
62. V Szatmari J Rothuizen TS van den Ingh FJ van Sluijs G Voorhout 2004 Ultrasonographic findings in dogs with hyperammonemia: 90 cases (2000-2002) J Am Vet Med Assoc 224 717 727 15008122 10.2460/javma.2004.224.717
63. V Szatmari J Rothuizen G Voorhout 2004 Standard planes for ultrasonographic examination of the portal system in dogs J Am Vet Med Assoc 224 713-716 698 699
64. V Szatmari FJ van Sluijs J Rothuizen G Voorhout 2004 Ultrasonographic assessment of hemodynamic changes in the portal vein during surgical attenuation of congenital extrahepatic portosystemic shunts in dogs J Am Vet Med Assoc 224 395 402 14765799 10.2460/javma.2004.224.395
65. A Thenappan Y Li K Kitisin A Rashid K Shetty L Johnson L Mishra 2010 Role of transforming growth factor beta signaling and expansion of progenitor cells in regenerating liver Hepatology 51 1373 1382 20131405 10.1002/hep.23449 1:CAS:528:DC%2BC3cXls1Cnur0%3D
66. PL Tisdall GB Hunt CR Bellenger R Malik 1994 Congenital portosystemic shunts in Maltese and Australian cattle dogs Aust Vet J 71 174 178 8080406 10.1111/j.1751-0813.1994.tb03382.x 1:STN:280:DyaK2czmtFKnug%3D%3D
67. KM Tobias 2003 Determination of inheritance of single congenital portosystemic shunts in Yorkshire terriers J Am Anim Hosp Assoc 39 385 389 12873029
68. KM Tobias BW Rohrbach 2003 Association of breed with the diagnosis of congenital portosystemic shunts in dogs: 2, 400 cases (1980-2002) J Am Vet Med Assoc 223 1636 1639 14664452 10.2460/javma.2003.223.1636
69. NJ Torok 2008 Recent advances in the pathogenesis and diagnosis of liver fibrosis J Gastroenterol 43 315 321 18592147 10.1007/s00535-008-2181-x 1:CAS:528:DC%2BD1cXnvFSms7s%3D
70. G Treiber A Csepregi P Malfertheiner 2005 The pathophysiology of portal hypertension Dig Dis 23 6 10 15920320 10.1159/000084720
71. A Tsai HJ Paltiel LM Sena HB Kim SJ Fishman AI Alomari 2009 Neonatal hemochromatosis and patent ductus venosus: clinical course and diagnostic pitfalls Pediatr Radiol 39 823 827 19458947 10.1007/s00247-009-1294-6
72. GJ Ubbink J van de Broek HP Meyer J Rothuizen 1998 Prediction of inherited portosystemic shunts in Irish Wolfhounds on the basis of pedigree analysis Am J Vet Res 59 1553 1556 9858405 1:STN:280:DyaK1M%2FnsVWitA%3D%3D
73. T Uchino I Matsuda F Endo 1999 The long-term prognosis of congenital portosystemic venous shunt J Pediatr 135 254 256 10431123 10.1016/S0022-3476(99) 70031-4 1:STN:280:DyaK1Mzmt1Gntw%3D%3D
74. TS van den Ingh J Rothuizen HP Meyer 1995 Circulatory disorders of the liver in dogs and cats Vet Q 17 70 76 7571284 10.1080/01652176.1995.9694536
75. FG van Steenbeek PA Leegwater FJ van Sluijs HC Heuven J Rothuizen 2009 Evidence of inheritance of intrahepatic portosystemic shunts in Irish Wolfhounds J Vet Intern Med 23 950 952 19496918 10.1111/j.1939-1676.2009.0319.x
76. G van Straten PA Leegwater M de Vries WE van den Brom J Rothuizen 2005 Inherited congenital extrahepatic portosystemic shunts in Cairn terriers J Vet Intern Med 19 321 324 15954545 10.1111/j.1939-1676.2005.tb02701.x
77. JC Vulgamott 1985 Portosystemic shunts Vet Clin North Am Small Anim Pract 15 229 242 3872504 1:STN:280:DyaL2M7mvFKhtQ%3D%3D
78. JA Walisser MK Bunger E Glover EB Harstad CA Bradfield 2004 Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele J Biol Chem 279 16326 16331 14764592 10.1074/jbc.M400784200 1:CAS:528: DC%2BD2cXivF2qtrk%3D
79. JA Walisser E Glover K Pande AL Liss CA Bradfield 2005 Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types Proc Natl Acad Sci USA 102 17858 17863 16301529 10.1073/pnas.0504757102 1:CAS:528:DC%2BD2MXhtlegs7vF
80. H Wege TH Brummendorf 2007 Telomerase activation in liver regeneration and hepatocarcinogenesis: Dr. Jekyll or Mr. Hyde? Curr Stem Cell Res Ther 2 31 38 18220890 10.2174/157488807779317062 1:CAS:528:DC%2BD2sXisVyhtr4%3D
81. H Wege MS Chui HT Le SC Strom MA Zern 2003 In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging Cell Transplant 12 897 906 14763510
82. SU Wiemann A Satyanarayana M Tsahuridu HL Tillmann L Zender J Klempnauer P Flemming S Franco MA Blasco MP Manns KL Rudolph 2002 Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis FASEB J 16 935 942 12087054 10.1096/fj.01-0977com 1:CAS:528:DC%2BD38XltlCltbg%3D
83. JT Winkler MW Bohling DM Tillson JC Wright AJ Ballagas 2003 Portosystemic shunts: diagnosis, prognosis, and treatment of 64 cases (1993-2001) J Am Anim Hosp Assoc 39 169 185 12617545
84. SM Wood JM Gleadle CW Pugh O Hankinson PJ Ratcliffe 1996 The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells J Biol Chem 271 15117 15123 8662957 10.1074/jbc.271.48.30392 1:CAS:528:DyaK28XjvVWmur0%3D
85. Y Yokoyama M Nagino Y Nimura 2007 Mechanism of impaired hepatic regeneration in cholestatic liver J Hepatobiliary Pancreat Surg 14 159 166 17384907 10.1007/s00534-006-1125-1
86. Y Yoshimoto R Shimizu T Saeki T Harada Y Sugio S Nomura H Tanaka 2004 Patent ductus venosus in children: a case report and review of the literature J Pediatr Surg 39 E1 E5 14694396 10.1016/j.jpedsurg.2003.09.035
87. MM Zandvliet J Rothuizen 2007 Transient hyperammonemia due to urea cycle enzyme deficiency in Irish wolfhounds J Vet Intern Med 21 215 218 17427379 10.1111/j.1939-1676.2007.tb02951.x 1:STN:280:DC%2BD2s3hvFCksQ%3D%3D
88. AL Zwingenberger FS Shofer 2007 Dynamic computed tomographic quantitation of hepatic perfusion in dogs with and without portal vascular anomalies Am J Vet Res 68 970 974 17764411 10.2460/ajvr.68.9.970