-
1
-
-
3543098600
-
Liver fibrosis: From the bench to clinical targets
-
Pinzani M, Rombouts K. Liver fibrosis: from the bench to clinical targets. Digest Liver Dis 2004;36:231-42.
-
(2004)
Digest Liver Dis
, vol.36
, pp. 231-242
-
-
Pinzani, M.1
Rombouts, K.2
-
2
-
-
0037220482
-
Liver fibrosi - from bench to bedside
-
Friedman SL. Liver fibrosi - from bench to bedside. J Hepatol 2003;38:S38-53.
-
(2003)
J Hepatol
, vol.38
-
-
Friedman, S.L.1
-
3
-
-
33847367730
-
Liver fibrosis: Cellular mechanisms of progression and resolution
-
Henderson NC, Iredale JP. Liver fibrosis: cellular mechanisms of progression and resolution. Clin Sci 2007;112:265-80.
-
(2007)
Clin Sci
, vol.112
, pp. 265-280
-
-
Henderson, N.C.1
Iredale, J.P.2
-
4
-
-
0034648757
-
Thrombin signalling and protease activated receptors
-
Coughlin SR. Thrombin signalling and protease activated receptors. Nature 2000;407:258-64.
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
5
-
-
33847363203
-
Models of livers fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
-
Iredale JP. Models of livers fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007;117:539-48.
-
(2007)
J Clin Invest
, vol.117
, pp. 539-548
-
-
Iredale, J.P.1
-
6
-
-
0029098308
-
Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury
-
Marra F, Grandaliano G, Valente Aj. et al. Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology 1995;22:780-7.
-
(1995)
Hepatology
, vol.22
, pp. 780-787
-
-
Marra, F.1
Grandaliano, G.2
Valente, A.3
-
7
-
-
0031891508
-
Expression of the thrombin receptor in human liver: Upregulation during acute and chronic injury
-
Marra F, De Franco R, Grappone C, et al. Expression of the thrombin receptor in human liver: upregulation during acute and chronic injury. Hepatology 1998;27:426-71.
-
(1998)
Hepatology
, vol.27
, pp. 426-471
-
-
Marra, F.1
De Franco, R.2
Grappone, C.3
-
8
-
-
1242314392
-
PAR1 antagonisms protects against experimental liver fibrosis, role of proteinase receptors in stellate cell activation
-
Fiorucci S, Antonelli E, Distrutti E, et al. PAR1 antagonisms protects against experimental liver fibrosis, role of proteinase receptors in stellate cell activation. Hepatology 2004;39:365-75
-
(2004)
Hepatology
, vol.39
, pp. 365-375
-
-
Fiorucci, S.1
Antonelli, E.2
Distrutti, E.3
-
9
-
-
0032126368
-
Thrombin simulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1
-
Chambers RC, Dabbagh K. McAnulty RJ, et al. Thrombin simulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J 1998;333:121-7.
-
(1998)
Biochem J
, vol.333
, pp. 121-127
-
-
Chambers, R.C.1
Dabbagh, K.2
McAnulty, R.J.3
-
10
-
-
0034614895
-
Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
-
Cunningham MA, Rondeau E, Chen X, et al. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 2000;191:455-62.
-
(2000)
J Exp Med
, vol.191
, pp. 455-462
-
-
Cunningham, M.A.1
Rondeau, E.2
Chen, X.3
-
11
-
-
0029862685
-
Thrombin functions as an inflammatory mediator through activation of its receptor
-
Cirino G, Cicala C, Bucci M, et al. Thrombin functions as an inflammatory mediator through activation of its receptor. J Exp Med 1996;183:821-7.
-
(1996)
J Exp Med
, vol.183
, pp. 821-827
-
-
Cirino, G.1
Cicala, C.2
Bucci, M.3
-
12
-
-
0029812590
-
The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice
-
Trejo J, Connolly A, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem 1996;271:21536-41.
-
(1996)
J Biol Chem
, vol.271
, pp. 21536-21541
-
-
Trejo, J.1
Connolly, A.2
Coughlin, S.R.3
-
13
-
-
0031935469
-
Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism
-
Dabbagh K, Laurent GJ, McAnulty RJ, et al. Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism. Thromb Haemost 1998;79:405-9.
-
(1998)
Thromb Haemost
, vol.79
, pp. 405-409
-
-
Dabbagh, K.1
Laurent, G.J.2
McAnulty, R.J.3
-
15
-
-
0034933683
-
Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor
-
Riewald M, Ruf W. Mechanistic coupling of protease signalling and initiation of coagulation by tissue factor. Proc Natl Acad Sci U S A 1999;98:7742-7.
-
(1999)
Proc Natl Acad Sci U S A
, vol.98
, pp. 7742-7747
-
-
Riewald, M.1
Ruf, W.2
-
16
-
-
0029157084
-
Inthrahepatic mast cells in chronic liver disease
-
Farrell DJ, Hines JE, Walls AF, et al. Inthrahepatic mast cells in chronic liver disease. Hepatology 1995;22:1175-81.
-
(1995)
Hepatology
, vol.22
, pp. 1175-1181
-
-
Farrell, D.J.1
Hines, J.E.2
Walls, A.F.3
-
17
-
-
0023126197
-
Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells
-
Schwartz LB, Irani AM, Roller K, et al. Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells. J Immunol 1987;138:2611-5.
-
(1987)
J Immunol
, vol.138
, pp. 2611-2615
-
-
Schwartz, L.B.1
Irani, A.M.2
Roller, K.3
-
18
-
-
0032409975
-
Systemic mastocytosis: A rare cause of noncirrhotic portal hypertension simulating autoimmune cholongitas - report of four cases
-
Kyrialou D, Koroumalis E, Konsolas J, et al. Systemic mastocytosis: a rare cause of noncirrhotic portal hypertension simulating autoimmune cholongitas - report of four cases. Am J Gastroenterol 1998;93:106-8.
-
(1998)
Am J Gastroenterol
, vol.93
, pp. 106-108
-
-
Kyrialou, D.1
Koroumalis, E.2
Konsolas, J.3
-
19
-
-
0029103294
-
A fatal case of portal hypertension complicating systemic mastocytosis in an adolescent
-
Fonga-Djimi HS, Gottrand F, Bonnevalle M, et al. A fatal case of portal hypertension complicating systemic mastocytosis in an adolescent. Eur J Pediatr 1995;154:819-21.
-
(1995)
Eur J Pediatr
, vol.154
, pp. 819-821
-
-
Fonga-Djimi, H.S.1
Gottrand, F.2
Bonnevalle, M.3
-
20
-
-
0036189530
-
Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors
-
Gaça MDA, Zhou X, Benyon RC. Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol 2002;36:362-9.
-
(2002)
J Hepatol
, vol.36
, pp. 362-369
-
-
Gaça, M.D.A.1
Zhou, X.2
Benyon, R.C.3
-
21
-
-
0034634622
-
Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor 1
-
Chambers RC, Leoni P, Blanc-Brude OP, et al. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor 1. J Biol Chem 2000;275:35584-91.
-
(2000)
J Biol Chem
, vol.275
, pp. 35584-35591
-
-
Chambers, R.C.1
Leoni, P.2
Blanc-Brude, O.P.3
-
22
-
-
0033592863
-
Plasminogen deficiency leads to impaired remodelling after a toxic injury to the liver
-
Bezerra J, Bugge TH, Melin-Aldan H, et al. Plasminogen deficiency leads to impaired remodelling after a toxic injury to the liver. Proc Natl Acad Sci U S A 1999;96:15143-8.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 15143-15148
-
-
Bezerra, J.1
Bugge, T.H.2
Melin-Aldan, H.3
-
23
-
-
0035742094
-
Plaminogen deficiency results in poor clearance of non-fibrin matrix and persitent activation of hepatic stellate cells after an acute injury
-
Lee Ng V, Sabla GE, Melin-Aldan H, et al. Plaminogen deficiency results in poor clearance of non-fibrin matrix and persitent activation of hepatic stellate cells after an acute injury. J Hepatol 2001;35:781-9.
-
(2001)
J Hepatol
, vol.35
, pp. 781-789
-
-
Lee Ng, V.1
Sabla, G.E.2
Melin-Aldan, H.3
-
24
-
-
0037369783
-
Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis
-
Papatheodoridis GV, Papakonstantinou E, Andrioti E, et al. Thrombotic risk factors and extent of liver fibrosis in chronic viral hepatitis. Gut 2003;52:404-9.
-
(2003)
Gut
, vol.52
, pp. 404-409
-
-
Papatheodoridis, G.V.1
Papakonstantinou, E.2
Andrioti, E.3
-
25
-
-
0038637369
-
Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatits C virus infection
-
Wright M, Goldin R, Hellier S, et al. Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatits C virus infection. Gut 2003;52:1206-10.
-
(2003)
Gut
, vol.52
, pp. 1206-1210
-
-
Wright, M.1
Goldin, R.2
Hellier, S.3
-
26
-
-
1942536463
-
Genetic and acquired thrombotic factors in chronic hepatitis C
-
Poujol-Robert A, Rosmorduc O, Serfaty L, et al. Genetic and acquired thrombotic factors in chronic hepatitis C. Am J Gastroenterol 2004;99:527-31.
-
(2004)
Am J Gastroenterol
, vol.99
, pp. 527-531
-
-
Poujol-Robert, A.1
Rosmorduc, O.2
Serfaty, L.3
-
27
-
-
17844385292
-
Hyperhomocysteinemia and the MTHFR C677T polymorophism promote steatosis and fibrosis in chronic hepatitis C
-
Adinolfi LE, Ingrosso D, Cesaro G, et al. Hyperhomocysteinemia and the MTHFR C677T polymorophism promote steatosis and fibrosis in chronic hepatitis C. Hepatology 2005;41:995-1003.
-
(2005)
Hepatology
, vol.41
, pp. 995-1003
-
-
Adinolfi, L.E.1
Ingrosso, D.2
Cesaro, G.3
-
28
-
-
33947425273
-
The impact of inherited prothrombic risk factors on individuals chronically infected with hepatitis C virus from a single source
-
Goulding C, O'Brien C, Egan H, et al. The impact of inherited prothrombic risk factors on individuals chronically infected with hepatitis C virus from a single source. J Viral Hepatitis 2006;14:255-9.
-
(2006)
J Viral Hepatitis
, vol.14
, pp. 255-259
-
-
Goulding, C.1
O'Brien, C.2
Egan, H.3
-
29
-
-
23044477984
-
Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
-
Hillebrandt S, Wasmuth HE, Weiskirchen R, et al. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 2005;37:8.
-
(2005)
Nat Genet
, vol.37
, pp. 8
-
-
Hillebrandt, S.1
Wasmuth, H.E.2
Weiskirchen, R.3
-
30
-
-
34547615744
-
Are chronic hepatitis C viral infections more benign in patients with hemophilia?
-
Assy N, Pettigrew N, Lee SS, et al. Are chronic hepatitis C viral infections more benign in patients with hemophilia? Am J Gastroenterol 2007;102:1672-6.
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 1672-1676
-
-
Assy, N.1
Pettigrew, N.2
Lee, S.S.3
-
31
-
-
0029829651
-
Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole
-
Wanless IR, Beljiorno J, Huet PM. Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole. Hepatology 1996;24:855-64.
-
(1996)
Hepatology
, vol.24
, pp. 855-864
-
-
Wanless, I.R.1
Beljiorno, J.2
Huet, P.M.3
-
32
-
-
0024375882
-
Current perspectives in the antiplatelet therapy of thrombotic disorders
-
Breddin HK. Current perspectives in the antiplatelet therapy of thrombotic disorders. Semin Thromb Hemost 1989;15:144-9.
-
(1989)
Semin Thromb Hemost
, vol.15
, pp. 144-149
-
-
Breddin, H.K.1
-
33
-
-
0030734831
-
Effects of pentoxifylline on degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-β1
-
Romanelli RG, Caligiuri A, Carloni V, et al. Effects of pentoxifylline on degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-β1. Br J Pharmacol 1997;122:1047-54.
-
(1997)
Br J Pharmacol
, vol.122
, pp. 1047-1054
-
-
Romanelli, R.G.1
Caligiuri, A.2
Carloni, V.3
-
34
-
-
0029958518
-
Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells
-
Pinzani M, Marra F, Caligiuri A, et al. Inhibition by pentoxifylline of extracellular signal-regulated kinase activation by platelet-derived growth factor in hepatic stellate cells. Br J Pharmacol 1996;119:1117-24.
-
(1996)
Br J Pharmacol
, vol.119
, pp. 1117-1124
-
-
Pinzani, M.1
Marra, F.2
Caligiuri, A.3
-
36
-
-
33746265975
-
Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats
-
Li G, Xie Q, Shi Y, et al. Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med 2006;8:889-900.
-
(2006)
J Gene Med
, vol.8
, pp. 889-900
-
-
Li, G.1
Xie, Q.2
Shi, Y.3
-
37
-
-
34247258487
-
The beneficial effects and enoxaparin on fibrosis progression and regenerative activity in the rat model of cirrhosis
-
Assy N, Hussain O, Khalil A, et al. The beneficial effects and enoxaparin on fibrosis progression and regenerative activity in the rat model of cirrhosis. Dig Dis Sci 2007;52:1187-93.
-
(2007)
Dig Dis Sci
, vol.52
, pp. 1187-1193
-
-
Assy, N.1
Hussain, O.2
Khalil, A.3
-
38
-
-
0023513315
-
Modulation by recombinant interleukin-1 of synthesis of type 1 and 111 collagen and associated procollagen RNA levels in cultured human cells
-
Gordring MB, Krane SM. Modulation by recombinant interleukin-1 of synthesis of type 1 and 111 collagen and associated procollagen RNA levels in cultured human cells. J Biol Chem 1987;262:16724-9.
-
(1987)
J Biol Chem
, vol.262
, pp. 16724-16729
-
-
Gordring, M.B.1
Krane, S.M.2
-
39
-
-
7044284909
-
A study of unfractionated and low molecular weight heparins in a model of cholestatic liver injury in the rat
-
Abdel-Salam OME, Baiuomy AR, Ameen A, et al. A study of unfractionated and low molecular weight heparins in a model of cholestatic liver injury in the rat. Pharmacol Res 2005;51:59-67.
-
(2005)
Pharmacol Res
, vol.51
, pp. 59-67
-
-
Abdel-Salam, O.M.E.1
Baiuomy, A.R.2
Ameen, A.3
-
40
-
-
33845677618
-
Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat
-
Abe W, Ikejima K, Lang T. Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat. J Hepatol 2007;46:286-94.
-
(2007)
J Hepatol
, vol.46
, pp. 286-294
-
-
Abe, W.1
Ikejima, K.2
Lang, T.3
-
41
-
-
0043066540
-
Effects of heparin on liver fibrosis in patients with chronic hepatitis B
-
Shi J, Hao JH, Ren WH. Effects of heparin on liver fibrosis in patients with chronic hepatitis B. World J Gastroenterol 2003;9:1611-4.
-
(2003)
World J Gastroenterol
, vol.9
, pp. 1611-1614
-
-
Shi, J.1
Hao, J.H.2
Ren, W.H.3
-
42
-
-
0029048868
-
Hepatic and portal vein thrombosis in cirrhosis: Possible role in the development of parenchymal extinction and portal hypertension
-
Wanless IR, Wong F, Blendis LM, et al. Hepatic and portal vein thrombosis in cirrhosis: possible role in the development of parenchymal extinction and portal hypertension. Hepatology 1995;21:1238-47.
-
(1995)
Hepatology
, vol.21
, pp. 1238-1247
-
-
Wanless, I.R.1
Wong, F.2
Blendis, L.M.3
-
43
-
-
33747386471
-
Close association between activated platelets and neutrophils in the active phase of ulcerative colitis in humans
-
Kayo S, Ikura Y, Suekane T, et al. Close association between activated platelets and neutrophils in the active phase of ulcerative colitis in humans. Inflamm Bowel Dis 2006;12:727-35.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 727-735
-
-
Kayo, S.1
Ikura, Y.2
Suekane, T.3
-
44
-
-
23044517437
-
Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectine and neutrophil-platelet interaction in human coronary unstable plaques
-
Ikuta T, Naruko T, Ikura Y, et al. Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectine and neutrophil-platelet interaction in human coronary unstable plaques. Int J Mol Med 2005;15:573-7.
-
(2005)
Int J Mol Med
, vol.15
, pp. 573-577
-
-
Ikuta, T.1
Naruko, T.2
Ikura, Y.3
-
46
-
-
34447317835
-
Proangiogenic cytochines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells
-
Novo E, Cannitto S, Zamara E, et al. Proangiogenic cytochines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. Am J Pathol 2007;170:1942-53.
-
(2007)
Am J Pathol
, vol.170
, pp. 1942-1953
-
-
Novo, E.1
Cannitto, S.2
Zamara, E.3
-
47
-
-
34648828394
-
Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosis
-
Samonakis DN, Cholongitas E, Thalheimer U, et al. Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosis. Liver Transplant 2007;13:1305- 11.
-
(2007)
Liver Transplant
, vol.13
, pp. 1305-1311
-
-
Samonakis, D.N.1
Cholongitas, E.2
Thalheimer, U.3
-
48
-
-
33645227469
-
Hepatic venous pressure gradient identifies patients at risk of severe hepatitis C recurrence after liver transplantation
-
Blasco A, Forns X, Carrion JA, et al. Hepatic venous pressure gradient identifies patients at risk of severe hepatitis C recurrence after liver transplantation. Hepatology 2006;43:492-9.
-
(2006)
Hepatology
, vol.43
, pp. 492-499
-
-
Blasco, A.1
Forns, X.2
Carrion, J.A.3
|