Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS)

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volumn 396, Issue , 2012, Pages 22-28

  Wei, Yinghui ^a   Ye, Xiaoli ^a   Shang, Xiaoguang ^a   Peng, Xuan ^a   Bao, Qiang ^a   Liu, Minchen ^a   Guo, Manman ^a   Li, Fanzhu ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Bioavailability; Precipitation; Self emulsifying drug delivery system; Silybin; Supersaturation

Indexed keywords

DROPS; DRUG DOSAGE; EMULSIFICATION; MICROEMULSIONS; PHASE DIAGRAMS; PRECIPITATION (CHEMICAL); SUPERSATURATION;

BIOAVAILABILITY; CONCENTRATION-TIME; DROPLET SIZES; HYDROXYPROPYL METHYLCELLULOSE; IN-VITRO; IN-VIVO; LABRAFAC; MEAN DROPLET SIZE; POORLY SOLUBLE DRUGS; POORLY WATER-SOLUBLE DRUGS; PRECIPITATION INHIBITORS; PRECIPITATION KINETICS; PSEUDOTERNARY PHASE DIAGRAMS; SELF-EMULSIFYING DRUG DELIVERY SYSTEM; SILYBIN; SOLUTION CONCENTRATION;

BIOCHEMISTRY;

CREMOPHOR; HYDROXYPROPYLMETHYLCELLULOSE; LABRASOL; SILIBININ;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DILUTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MICROEMULSION; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SUPERSATURATABLE SELF EMULSIFYING DRUG DELIVERY SYSTEM; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84857356952     PISSN: 09277757     EISSN: 18734359     Source Type: Journal    
DOI: 10.1016/j.colsurfa.2011.12.025     Document Type: Article

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