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Journal of Pharmaceutical and Biomedical Analysis

Volumn 45, Issue 4, 2007, Pages 635-641

Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application

(5) Wu, Jhy Wen a,b Lin, Lie Chwen a,c Hung, Shih Chieh a,d Chi, Chin Wen a,d Tsai, Tung Hu a,e

a NATIONAL YANG MING UNIVERSITY (Taiwan)

b CENTER FOR DISEASE CONTROL (Taiwan)

c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE (Taiwan)

d TAIPEI VETERANS GENERAL HOSPITAL (Taiwan)

e TAIPEI CITY HOSPITAL (Taiwan)

Author keywords

Bioavailability; Herbal medicine; Milk thistle; Silybum marianum; Silymarin

Indexed keywords

ACETONITRILE; HERBACEOUS AGENT; NARINGENIN; PHOSPHORIC ACID; SILIBININ; SODIUM DIHYDROGEN PHOSPHATE; SOLVENT;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILE; BILE FLOW; BLOOD; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG PROTEIN BINDING; DRUG STRUCTURE; FLOW RATE; HEPATOBILIARY SYSTEM; HERBAL MEDICINE; INTER ASSAY PRECISION; INTRA ASSAY PRECISION; LIMIT OF ACCEPTABILITY; LIQUID CHROMATOGRAPHY; NONHUMAN; PARAMETER; PH; PLASMA; PRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SILYBUM MARIANUM; SINGLE DRUG DOSE; ULTRAFILTRATION; ULTRAVIOLET RADIATION; VORTEX MOTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; BILE; BIOLOGICAL AVAILABILITY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INJECTIONS, INTRAVENOUS; LIVER; MALE; METABOLIC DETOXICATION, PHASE II; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SILYMARIN; TISSUE DISTRIBUTION;

EID: 35548931533 PISSN: 07317085 EISSN: None Source Type: Journal
DOI: 10.1016/j.jpba.2007.06.026 Document Type: Article

Times cited : (153)

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