Elevated physiological levels of folic acid can increase in vitro growth and invasiveness of prostate cancer cells

BJU International

Volumn 109, Issue 5, 2012, Pages 788-795

  Petersen, Lars F ^a   Brockton, Nigel T ^b   Bakkar, Ashraf ^a,c   Liu, Shuhong ^a   Wen, Jing ^a   Weljie, Aalim M ^a   Bismar, Tarek A ^d,e  

^a UNIVERSITY OF CALGARY   (Canada)

^b ALBERTA HEALTH SERVICES   (Canada)

^c Sinai University   (Egypt)

^d TOM BAKER CANCER CENTRE   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

folic acid; invasion; metabolomics; prostate cancer; sarcosine

Indexed keywords

BIOLOGICAL MARKER; FOLIC ACID; SARCOSINE;

ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER RISK; CARCINOGENESIS; CELL COUNT; CELL CULTURE; CELL INVASION; CELL LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FOLATE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM CARE; METABOLOMICS; PRIORITY JOURNAL; PROSTATE CANCER; VITAMIN SUPPLEMENTATION;

CELL PROLIFERATION; FOLIC ACID; HUMANS; MALE; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; SARCOSINE; TUMOR CELLS, CULTURED;

EID: 84857355237     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2011.10437.x     Document Type: Article

References (44)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ,. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225-49
2. Mazhar D, Waxman J,. Diet and prostate cancer. BJU Int 2004; 93: 919-22 (Pubitemid 38758607)
3. Shirai T, Asamoto M, Takahashi S, Imaida K,. Diet and prostate cancer. Toxicology 2002; 181-182: 89-94 (Pubitemid 36015678)
4. Zlotta A,. Weighing the data on diet and prostate cancer. Can Urol Assoc J 2008; 2: 516-7
5. James SJ, Basnakian AG, Miller BJ,. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res 1994; 54: 5075-80 (Pubitemid 24313479)
6. Lucock M,. Is folic acid the ultimate functional food component for disease prevention? BMJ 2004; 328: 211-4 (Pubitemid 38147076)
7. Bertino JR,. Cancer research: from folate antagonism to molecular targets. Best Pract Res Clin Haematol 2009; 22: 577-82
8. Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB,. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 2000; 72: 998-1003
9. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ,. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 2000; 275: 29318-23 (Pubitemid 32043802)
10. Jhaveri MS, Wagner C, Trepel JB,. Impact of extracellular folate levels on global gene expression. Mol Pharmacol 2001; 60: 1288-95 (Pubitemid 33144900)
11. Choi SW, Mason JB,. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 2002; 132: 2413S-8S (Pubitemid 34848118)
12. Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I,. Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev 2006; 15: 443-8
13. Kim Y,. Does a high folate intake increase the risk of breast cancer? Nutr Rev 2006; 64: 468-75 (Pubitemid 44582079)
14. Kim YI,. Role of folate in colon cancer development and progression. J Nutr 2003; 133: 3731S-9S
15. Ulrich C, Potter J,. Folate and cancer-timing is everything. JAMA 2007; 297: 2408-9
16. Ulrich CM, Potter JD,. Folate supplementation: too much of a good thing? Cancer Epidemiol Biomarkers Prev 2006; 15: 189-93 (Pubitemid 43342163)
17. Cole BF, Baron JA, Sandler RS, et al,. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007; 297: 2351-9 (Pubitemid 46883748)
18. Kim YI,. Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen 2004; 44: 10-25
19. Figueiredo JC, Grau MV, Haile RW, et al,. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 2009; 101: 432-5
20. Pfeiffer CM, Johnson CL, Jain RB, et al,. Trends in blood folate and vitamin B-12 concentrations in the United States, 1988-2004. Am J Clin Nutr 2007; 86: 718-27 (Pubitemid 47435840)
21. Yeung L, Yang Q, Berry RJ,. Contributions of total daily intake of folic acid to serum folate concentrations. JAMA 2008; 300: 2486-7
22. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991; 338: 131-7
23. Wald N,. Folic acid and the prevention of neural tube defects. Ann N Y Acad Sci 1993; 678: 112-29 (Pubitemid 23158892)
24. Brosnan JT, Jacobs RL, Stead LM, Brosnan ME,. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol 2004; 51: 405-13 (Pubitemid 38969303)
25. Sreekumar A, Poisson LM, Rajendiran TM, et al,. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009; 457: 910-4
26. Luka Z, Mudd SH, Wagner C,. Glycine N-methyltransferase and regulation of S-adenosylmethionine levels. J Biol Chem 2009; 284: 22507-11
27. Takata Y, Huang Y, Komoto J, et al,. Catalytic mechanism of glycine N-methyltransferase. Biochemistry 2003; 42: 8394-402 (Pubitemid 36875404)
28. Beagle B, Yang TL, Hung J, Cogger EA, Moriarty DJ, Caudill MA,. The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake. J Nutr 2005; 135: 2780-5 (Pubitemid 43156541)
29. Bligh EG, Dyer WJ,. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-7
30. Hummel J, Strehmel N, Selbig J, Walther D, Kopka J,. Decision tree supported substructure prediction of metabolites from GC-MS profiles. Metabolomics 2010; 6: 322-33
31. Kimura M, Umegaki K, Higuchi M, Thomas P, Fenech M,. Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J Nutr 2004; 134: 48-56 (Pubitemid 38057422)
32. Yao V, Bacich D,. Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro. Prostate 2006; 66: 867-75
33. Yao V, Berkman CE, Choi JK, O'Keefe DS, Bacich DJ,. Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Prostate 2010; 70: 305-16
34. Ni J, Lu L, Fenech M, Wang X,. Folate deficiency in human peripheral blood lymphocytes induces chromosome 8 aneuploidy but this effect is not modified by riboflavin. Environ Mol Mutagen 2010; 51: 15-22
35. Wang X, Thomas P, Xue J, Fenech M,. Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21. Mutat Res 2004; 551: 167-80 (Pubitemid 38833506)
36. Wang X, Fenech M,. A comparison of folic acid and 5- methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagenesis 2003; 18: 81-6 (Pubitemid 36118822)
37. Sunden SL, Renduchintala MS, Park EI, Miklasz SD, Garrow TA,. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys 1997; 345: 171-4 (Pubitemid 27374220)
38. Luka Z,. Methyltetrahydrofolate in folate-binding protein glycine N-methyltransferase. Vitam Horm 2008; 79: 325-45
39. Rowling MJ, McMullen MH, Chipman DC, Schalinske KL,. Hepatic glycine N-methyltransferase is up-regulated by excess dietary methionine in rats. J Nutr 2002; 132: 2545-50 (Pubitemid 35013232)
40. Huang YC, Lee CM, Chen M, et al,. Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer. Clin Cancer Res 2007; 13: 1412-20 (Pubitemid 46450430)
41. Couzin J,. Biomarkers. Metabolite in urine may point to high-risk prostate cancer. Science 2009; 323: 865
42. Struys EA, Heijboer AC, van Moorselaar J, Jakobs C, Blankenstein MA,. Serum sarcosine is not a marker for prostate cancer. Ann Clin Biochem 2010; 47: 282
43. Jentzmik F, Stephan C, Miller K, et al,. Sarcosine in Urine after Digital Rectal Examination Fails as a Marker in Prostate Cancer Detection and Identification of Aggressive Tumours. Eur Urol 2010; 58: 12-8
44. Sreekumar A, Poisson LM, Rajendiran TM, et al,. Re: Florian Jentzmik, Carsten Stephan, Kurt Miller et al. Sarcosine in Urine after Digital Rectal Examination Fails as a Marker in Prostate Cancer Detection and Identification of Aggressive Tumours. Eur Urol 2010; 58: 12-8. Eur Urol 2010; 58: e29-30; author reply e2-2