Complement components, but not complement inhibitors, are upregulated in atherosclerotic plaques

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 7, 2001, Pages 1214-1219

  Yasojima, K ^a   Schwab, C ^a   McGeer, E G ^a   McGeer, P L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

C4 binding protein; CD46; CD59; Classical pathway; Inflammation

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BINDING PROTEIN; CD59 ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C4; COMPLEMENT INHIBITOR; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN; MESSENGER RNA;

ARTICLE; ATHEROSCLEROTIC PLAQUE; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MESSENGER RNA SYNTHESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TISSUE LEVEL; WESTERN BLOTTING;

EID: 0035723345     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0701.092160     Document Type: Article

References (37)

1. Localization of the terminal C5b-9 complement complex in the human aortic atherosclerotic wall
2. Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis
3. Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque
4. Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion
5. Roles of infectious agents in atherosclerosis and restenosis: An assessment of the evidence and need for future research
6. High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis
7. Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma: Evaluation of the innocent bystander hypothesis
8. Cytomegalovirus and atherosclerosis
9. The complement system in atherosclerosis
10. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries
11. Generation of C-reactive protein and complement components in atherosclerotic plaques
12. Interactions of C-reactive protein with the complement system
13. CRP-mediated activation of complement in vivo
14. Acute-phase proteins and other systemic responses to inflammation
15. Physiology and pathophysiology of complement progress and trends
16. Control of C3b and C5b deposited by CD46 (membrane cofactor protein) after alternative but not classical complement activation
17. Membrane cofactor protein (MCP CD46): Isoforms differ in protection against the classical pathway of complement
18. Complement regulators C1 inhibitor and CD59 do not significantly inhibit complement activation in Alzheimer disease
19. Upregulated production and activation of the complement system in Alzheimer's disease brain
20. Human heart generates complement proteins that are upregulated and activated after myocardial infarction
21. Extensive postmortem stability of RNA from rat and human brain
22. The isolation and in vitro translation of undegraded messenger RNAs from human postmortem brain
23. Immune system response in Alzheimer's disease
24. Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease
25. Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain
26. A simple sequentially repetitive multiple test procedure
27. CD59 (homologous restriction factor 20), a plasma membrane protein that protects against complement C5b-9 attack, in human atherosclerotic lesions
28. mRNA expression of complement proteins and regulators in rat smooth muscle cells
29. Ba and Bb fragments of factor B activation: Fragment production, biological activities, neoepitope expression and quantitation in clinical samples
30. Growth-promoting effects of oxidized low density lipoprotein
31. Atherosclerosis: An inflammatory disease
32. Human neurons generate C-reactive protein and amyloid P: Upregulation in Alzheimer's disease
33. Deposition of the terminal C5b-9 complex in infarcted areas of human myocardium
34. C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction
35. Mechanism of complement-dependent hemolysis via the lectin pathway: Role of the complement regulatory proteins
36. The mannan-binding-lectin pathway of the innate immune response
37. Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion