Induction of antibodies reactive with SSA/Ro-SSB/La and development of congenital heart block in a murine model

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 5886-5892

  Miranda Carús, M Eugenia ^a   Boutjdir, Mohamed ^b   Tseng, Chung E ^a   DiDonato, Francis ^a   Chan, Edward K L ^c   Buyon, Jill P ^a  

^a NYU HOSPITAL FOR JOINT DISEASES   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIBODY; ANTIGEN; AUTOANTIBODY; BETA GALACTOSIDASE; MESSENGER RNA; POLYPEPTIDE; PROTEIN; RIBONUCLEOPROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CONGENITAL HEART BLOCK; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FEMALE; HEART BLOCK; HEART CONDUCTION SYSTEM; HUMANS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; MYOCARDIUM; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC;

EID: 0032403581     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Buyon, J. P. 1992. Neonatal lupus syndromes. In Systemic Lupus Erythematosus. R. Lahita, ed. Churchill Livingstone, New York, p. 419.
2. Lee, L. A. 1993. Neonatal lupus erythematosus. J. Invest. Dermatol. 100:9S.
3. Buyon, J. P., and R. Winchester. 1990. Congenital complete heart block: a human model of passively acquired autoimmune injury. Arthritis Rheum. 33:609.
4. McCue, C. M., M. E. Mantakas, and J. B. Tingelstad. 1977. Congenital heart block in newborns of mothers with connective tissue disease. Circulation 56:82.
5. Ben-Chetrit, E., B. J. Gandy, E. M. Tan, and K. F. Sullivan. 1989. Isolation and characterization of a cDNA clone encoding the 60-kDa component of the human SS-A/Ro ribonucleoprotein autoantigen. J. Clin. Invest. 83:1284.
6. Deutscher, S. L., J. B. Harley, and J. D. Keene. 1988. Molecular analysis of the 60-kDa human Ro ribonucleoprotein. Proc. Natl. Acad. Sci. USA 85:9479.
7. Lerner, M. R., J. A. Boyle, J. A. Hardin, and J. A. Steitz. 1981. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science 211:400.
8. Wang, D., J. P. Buyon, and E. K. L. Chan. 1996. Cloning and expression of mouse 60-kDa ribonucleoprotein SS-A/Ro. Mol. Biol. Rep. 23:205.
9. O'Brien, C. A., and S. L. Wolin. 1994. A possible role for the 60-kDa Ro autoantigen in a discard pathway for defective 5s rRNA precursors. Genes Dev. 8:2891.
10. Chan, E. K. L., K. F. Sullivan, and E. M. Tan. 1989. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. Nucleic Acids Res. 17:2233.
11. Chambers, J. C., D. Kenan, B. J. Martin, and J. D. Keene. 1988. Genomic structure and amino acid sequence domains of the human La autoantigen. J. Biol. Chem. 263:18043.
12. Gottlieb, E., and J. A. Steitz. 1989. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. EMBO J. 8:851.
13. Boire, B., and J. Craft. 1990. Human Ro ribonucleoprotein particles: characterization of native structure and stable association with the La polypeptide. J. Clin. Invest. 85:1182.
14. Ben-Chetrit, E., E. K. L. Chan, K. F. Sullivan, and E. M. Tan. 1988. A 52-kDa protein is a novel component of the SS-A/Ro antigenic particle. J. Exp. Med. 162:1560.
15. Chan, E. K. L., J. C. Hamel, J. P. Buyon, and E. M. Tan. 1991. Molecular definition and sequence motifs of the 52-kDa component of human SS-A/Ro autoantigen. J. Clin. Invest. 87:68.
16. Itoh, K., Y. Itoh, and M. B. Frank. 1991. Protein heterogeneity in the human Ro/SSA ribonucleoproteins. J. Clin. Invest. 87:177.
17. Chan, E. K. L., F. DiDonato, J. C. Hamel, C. E. Tseng, and J. P. Buyon. 1995. 52-kDa SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart. J. Exp. Med. 182:983.
18. Buyon, J. P., S. G. Slade, J. D. Reveille, J. C. Hamel, and E. K. L. Chan. 1994. Autoantibody responses to the "native" 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjögren's syndrome. J. Immunol. 152:3675.
19. Blange, I., N. R. Ringertz, and I. Pettersson. 1994. Identification of antigenic regions of the human 52-kDa Ro/SS-A protein recognized by patient sera. J. Autoimmun. 7:263.
20. Buyon, J. P., C. E. Tseng, F. DiDonato, W. Rashbaum, A. Morris, and E. K. L. Chan. 1997. Cardiac expression of 52β, an alternative transcript of the congenital heart block-associated 52-kDa SS-A/Ro autoantigen, is maximal during fetal development. Arthritis Rheum. 40:655.
21. Horsfall, A. C., P. J. W. Venables, P. V. Taylor, and R. N. Maini. 1991. Ro and La antigens and maternal autoantibody idiotype on the surface of myocardial fibres in congenital heart block. J. Autoimmun. 4:165.
22. Reichlin, M., A. Brucato, M. B. Frank, P. J. Maddison, V. R. McCubbin, M. Wolfson-Reichlin, and L. A. Lee. 1994. Concentration of autoantibodies to native 60-kDa Ro/SS-A and denatured 52-kDa Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum. 37: 1698.
23. Garcia, S., J. H. Nascimento, E. Bonfa, R. Levy, S. F. Oliveira, A. V. Tavares, and A. C. de Carvalho. 1994. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts. J. Clin. Invest. 93:718.
24. Boutjdir, M., L. Chen, Z. Zhang, C. Tseng, F. DiDonato, W. Rashbaum, A. Morris, N. El-Sherif, and J. P. Buyon. 1997. Arrhythmogenicity of IgG and anti-52-kDa SSA/Ro affinity-purified antibodies from mothers of children with congenital heart block. Circ. Res. 80:354.
25. Buyon, J. P., R. J. Winchester, S. G. Slade, F. Arnett, J. Copel, D. Friedman, and M. D. Lockshin. 1993. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children: comparison of ELISA and immunoblot to measure anti-SSA/Ro and anti-SSB/La antibodies. Arthritis Rheum. 36:1263.
26. Buyon, J. P., S. G. Slade, E. K. L. Chan, E. M. Tan, and R. J. Winchester. 1990. Effective separation of the 52-kDa SSA/Ro polypeptide from the 48-kDa SSB/La polypeptide by altering conditions of polyacrylamide gel electrophoresis. J. Immunol. Methods 129:207.
27. Tseng, C. E., E. K. L. Chan, E. Miranda, M. Gross, F. DiDonato, and J. P. Buyon. 1997. The 52-kDa protein as a target of intermolecular spreading of the immune response to components of the SSA/Ro-SSB/La complex. Arthritis Rheum. 40: 936.
28. Topfer, F., T. Gordon, and J. McCluskey. 1993. Characterization of the mouse autoantigen La (SS-B): identification of conserved RNA-binding motifs, a putative ATP binding site, and reactivity of recombinant protein with poly(U) and human autoantibodies. J. Immunol. 150:3091.
29. Keech, C. L., T. P. Gordon, and J. McCluskey. 1996. Structural differences between the human and mouse 52-kDa Ro autoantigens associated with poorly conserved autoantibody activity across species. Clin. Exp. Immunol. 104:255.
30. Ramsey-Goldman, R., D. Hom, J. S. Deng, G. C. Ziegler, L. E. Kahl, V. D. Steen, R. E. LaPorte, and T. A. Medsger, Jr. 1986. Anti-SSA/A antibodies and fetal outcome in maternal systemic lupus erythematosus. Arthritis Rheum. 29:1269.
31. Lockshin, M. D., E. Bonfa, K. Elkon, and M. L. Druzin. 1988. Neonatal risk to newborns of mothers with systemic lupus erythematosus. Arthritis Rheum. 31: 697.
32. Simmons-O'Brien, E., S. Chen, R. Watson, C. Antoni, M. Petri, M. Hochberg, M. B. Stevens, and T. T. Provost. 1995. One hundred anti-Ro (SS-A) antibody-positive patients: a 10-year follow-up. Medicine 74:109.
33. Michaelsson, M., and M. A. Engle. 1972. Congenital complete heart block: an international study of the natural history. Cardiovasc. Clin. 4:85.
34. Fritzler, M. J., J. D. Pauls, T. D. Kinsella, and T. J. Bowen. 1985. Antinuclear, anti-cytoplasmic, and anti-Sjögren's syndrome antigen A (SS-A/Ro) antibodies in female blood donors. Clin. Immunol. Immunopathol. 36:120.
35. Buyon, J. P., J. Waltuck, K. Caldwell, B. Crawford, S. G. Slade, J. Copel, and E. K. L. Chan. 1994. Relationship between maternal and neonatal levels of antibodies to 48-kDa SSB(La), 52-kDa SSA(Ro), and 60-kDa SSA(Ro) in pregnancies complicated by congenital heart block. J Rheumatol. 21:1943.
36. Buyon, J. P., R. Hiebert, J. Copel, J. Craft, D. Friedman, M. Katholi, L. A. Lee, T. T. Provost, M. Reichlin, L. Rider, A. Rupel, S. Saleeb, W. Weston, and M. L. Skovron. 1998. Autoimmune-associated congenital heart block: demographics, mortality, morbidity, and recurrence rates obtained from a national neonatal lupus registry. J. Am. Coll. Cardiol. 31:1658.
37. Kalush, F., E. Rimon, A. Keller, and E. Mozes. 1994. Neonatal lupus erythematosus with cardiac involvement in offspring of mothers with experimental systemic lupus erythematosus. J. Clin. Immunol. 14:314.
38. Buyon, J. P., E. Ben-Chetrit, S. Karp, R. A. S. Roubey, L. Pompeo, W. H. Reeves, E. M. Tan, and R. Winchester. 1989. Acquired congenital heart block: pattern of maternal response to biochemically defined antigens of the SSA/Ro-SSB/La system. J. Clin. Invest. 84:627.
39. Julkunen, H., P. Kurki, R. Kaaja, R. Heikkila, I. Ilkka, E. K. L. Chan, E. Wallgren, and C. Friman. 1993. Isolated congenital heart block: long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La. Arthritis Rheum. 36:1588.