Nuclear Factor (NF) κB polymorphism is associated with heart function in patients with heart failure

BMC Medical Genetics

Volumn 11, Issue 1, 2010, Pages

  Santos, Diogo G B ^a   Resende, Marina F ^a   Mill, José G ^b   Mansur, Alfredo J ^a   Krieger, José E ^a   Pereira, Alexandre C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NFKB1 PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEART EJECTION FRACTION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE VOLUME; HEART RIGHT VENTRICLE VOLUME; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; AGED; ALLELE; COHORT ANALYSIS; CONGESTIVE CARDIOMYOPATHY; FOLLOW UP; GENETIC PREDISPOSITION; GENETICS; HEART VENTRICLE; KAPLAN MEIER METHOD; MIDDLE AGED; PATHOPHYSIOLOGY; PROMOTER REGION;

ADULT; AGED; ALLELES; CARDIOMYOPATHY, DILATED; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEART FAILURE; HEART VENTRICLES; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NF-KAPPA B P50 SUBUNIT; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 77953209261     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-11-89     Document Type: Article

References (31)

1. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 2000, 35:569-582. 10.1016/S0735-1097(99)00630-0, 10716457.
2. St John Sutton M, Pfeffer MA, Plappert T, Rouleau JL, Moye LA, Dagenais GR, Lamas GA, Klein M, Sussex B, Goldman S, et al. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril. Circulation 1994, 89:68-75.
3. Bolognese L, Neskovic AN, Parodi G, Cerisano G, Buonamici P, Santoro GM, Antoniucci D. Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications. Circulation 2002, 106:2351-2357. 10.1161/01.CIR.0000036014.90197.FA, 12403666.
4. Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18:6853-6866. 10.1038/sj.onc.1203239, 10602461.
5. Wong SC, Fukuchi M, Melnyk P, Rodger I, Giaid A. Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. Circulation 1998, 98:100-103.
6. Valen G, Yan ZQ, Hansson GK. Nuclear factor kappa-B and the heart. J Am Coll Cardiol 2001, 38:307-314. 10.1016/S0735-1097(01)01377-8, 11499717.
7. Gilmore TD. The Rel/NF-kappaB signal transduction pathway: introduction. Oncogene 1999, 18:6842-6844. 10.1038/sj.onc.1203237, 10602459.
8. Norman DA, Yacoub MH, Barton PJ. Nuclear factor NF-kappa B in myocardium: developmental expression of subunits and activation by interleukin-1 beta in cardiac myocytes in vitro. Cardiovasc Res 1998, 39:434-441. 10.1016/S0008-6363(98)00118-7, 9798528.
9. Heron E, Deloukas P, van Loon AP. The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction. Genomics 1995, 30:493-505. 10.1006/geno.1995.1270, 8825636.
10. Baldwin AS. Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest 2001, 107:3-6. 10.1172/JCI11891, 198555, 11134170.
11. Chen F, Castranova V, Shi X, Demers LM. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 1999, 45:7-17.
12. Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001, 107:7-11. 10.1172/JCI11830, 198552, 11134171.
13. Frantz S, Tillmanns J, Kuhlencordt PJ, Schmidt I, Adamek A, Dienesch C, Thum T, Gerondakis S, Ertl G, Bauersachs J. Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury. Am J Pathol 2007, 171:507-512. 10.2353/ajpath.2007.061042, 1934536, 17556593.
14. Frantz S, Hu K, Bayer B, Gerondakis S, Strotmann J, Adamek A, Ertl G, Bauersachs J. Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction. FASEB J 2006, 20:1918-1920. 10.1096/fj.05-5133fje, 16837548.
15. Kawano S, Kubota T, Monden Y, Tsutsumi T, Inoue T, Kawamura N, Tsutsui H, Sunagawa K. Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 2006, 291:H1337-1344. 10.1152/ajpheart.01175.2005, 16632551.
16. Kawamura N, Kubota T, Kawano S, Monden Y, Feldman AM, Tsutsui H, Takeshita A, Sunagawa K. Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy. Cardiovasc Res 2005, 66:520-529. 10.1016/j.cardiores.2005.02.007, 15914117.
17. Brown M, McGuinness M, Wright T, Ren X, Wang Y, Boivin GP, Hahn H, Feldman AM, Jones WK. Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo. Am J Physiol Heart Circ Physiol 2005, 289:H466-476. 10.1152/ajpheart.00170.2004, 15695559.
18. Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, et al. The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression. Circ Res 2009, 105:70-79. 10.1161/CIRCRESAHA.108.193318, 19478205.
19. Timmers L, van Keulen JK, Hoefer IE, Meijs MF, van Middelaar B, den Ouden K, van Echteld CJ, Pasterkamp G, de Kleijn DP. Targeted deletion of nuclear factor kappaB p50 enhances cardiac remodeling and dysfunction following myocardial infarction. Circ Res 2009, 104:699-706. 10.1161/CIRCRESAHA.108.189746, 19168865.
20. Timmers L, Sluijter JP, van Keulen JK, Hoefer IE, Nederhoff MG, Goumans MJ, Doevendans PA, van Echteld CJ, Joles JA, Quax PH, et al. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 2008, 102:257-264. 10.1161/CIRCRESAHA.107.158220, 18007026.
21. Misra A, Haudek SB, Knuefermann P, Vallejo JG, Chen ZJ, Michael LH, Sivasubramanian N, Olson EN, Entman ML, Mann DL. Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation 2003, 108:3075-3078. 10.1161/01.CIR.0000108929.93074.0B, 14676146.
22. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004, 13:35-45. 10.1093/hmg/ddh008, 14613970.
23. Park JY, Farrance IK, Fenty NM, Hagberg JM, Roth SM, Mosser DM, Wang MQ, Jo H, Okazaki T, Brant SR, Brown MD. NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives. Am J Physiol Heart Circ Physiol 2007, 293:H2320-2327. 10.1152/ajpheart.00186.2007, 2614625, 17644577.
24. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971, 285:1441-1446.
25. Hunt SA. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 2005, 46:e1-82. 10.1016/j.jacc.2005.08.022, 16168273.
26. Pereira AC, Sposito AC, Mota GF, Cunha RS, Herkenhoff FL, Mill JG, Krieger JE. Endothelial nitric oxide synthase gene variant modulates the relationship between serum cholesterol levels and blood pressure in the general population: new evidence for a direct effect of lipids in arterial blood pressure. Atherosclerosis 2006, 184:193-200. 10.1016/j.atherosclerosis.2005.03.035, 15916766.
27. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978, 58:1072-1083.
28. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988, 16:1215. 10.1093/nar/16.3.1215, 334765, 3344216.
29. Pereira SG, Oakley F. Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol 2008, 40:1425-1430. 10.1016/j.biocel.2007.05.004, 17693123.
30. Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004, 18:2195-2224. 10.1101/gad.1228704, 15371334.
31. Zhou B, Rao L, Peng Y, Wang Y, Li Y, Gao L, Chen Y, Xue H, Song Y, Liao M, Zhang L. Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy. BMC Med Genet 2009, 10:47. 10.1186/1471-2350-10-47, 2692851, 19480714.