Immunostimulatory and cytotoxic activities of Indigofera suffruticosa (Fabaceae)

Natural Product Research

Volumn 25, Issue 19, 2011, Pages 1796-1806

  Lopes, Flávia C M ^a   Calvo, Tamara R ^a   Colombo, Lucas L ^b   Vilegas, Wagner ^a   Carlos, Iracilda Z ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

alkaloidal fraction; indigo; nitric oxide; tumour cell lines; tumour necrosis factor

Indexed keywords

ANTINEOPLASTIC AGENT; INDIGOFERA SUFFRUTICOSA EXTRACT; NITRIC OXIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST ADENOCARCINOMA; CELL FUNCTION; CYTOTOXICITY; DRUG ACTIVITY; FABACEAE; IMMUNE SYSTEM; IMMUNOSTIMULATION; INDIGOFERA SUFFRUTICOSA; LUNG ADENOCARCINOMA; MACROPHAGE ACTIVATION; NONHUMAN; TUMOR CELL;

ADJUVANTS, IMMUNOLOGIC; ALKALOIDS; ANIMALS; BRAZIL; CELL LINE, TUMOR; CYTOTOXINS; DRUG DISCOVERY; INDIGOFERA; INDOLES; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; NITRIC OXIDE; PLANT EXTRACTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84857205288     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2010.488624     Document Type: Article

References (44)

1. Baker, SJ, and, Reddy, EP. 1998. Modulation of life and death by the TNF receptor superfamily. Oncogene, 17: 3261-3270. (Pubitemid 29043978)
2. Beutler, B, and, Cerami, A. 1989. The biology of cachectin/TNF: A primary mediator of the host response. Annual Review of Immunology, 7: 625-655. (Pubitemid 19138027)
3. Bogdan, C, Rollinghoff, M, and, Diefenbach, A. 2000. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Current Opinion in Immunology, 12: 64-76. (Pubitemid 30093452)
4. Bray, F, McCarron, P, and, Parkin, DM. 2004. The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Research, 6: 229-239. (Pubitemid 39440251)
5. Calvo, TR, Cardoso, RPC, Moura, ACS, Santos, LCS, Colus, IMS, Vilegas, W. 2011. Mutagenic activity of Indigofera truxillensis and I. suffruticosa aerial parts. Evidence-Based Complementary and Alternative Medicine,: 1-8.
6. Chanayath, N, Lhiochaiphant, S, and, Phutrakul, S. 2002. Pigment extraction techiques from the leaves of Indigofera tinctoria Linn. and Baphicacanthus cusia Brem. and chemical structure analysis of their major components. Chiang Mai University Journal, 1: 149-160.
7. Cragg, GM, and, Newman, DJ. 2005. Plants as a source of anti-cancer agents. Jounal of Ethnopharmacology, 100: 72-79. (Pubitemid 41073525)
8. Devasagayam, TPA, and, Sainis, KB. 2002. Immune system and antioxidants, especially those derived from Indian medicinal plants. Indian Journal of Experimental Biology, 40: 639-655. (Pubitemid 34604536)
9. Eggermont, AM, de Wilt, JH, and, ten Hagen, TL. 2003. Current uses of isolated limb perfusion in the clinic and a model system for new strategies. Lancet Oncology, 4: 429-437. (Pubitemid 36833685)
10. Eisenbrand, G, Hippe, F, Jakobs, S, and, Muehlbeyer, S. 2004. Molecular mechanisms of indirubin and its derivatives: Novel anticancer molecules with their origin in traditional Chinese phytomedicine. Journal of Cancer Research and Clinical Oncology, 130: 627-635. (Pubitemid 39506375)
11. Ganju, L, Karan, D, Chanda, S, Srivastava, KK, Sawhney, RC, and, Selvamurthy, W. 2003. Immunomodulatory effects of agents of plant origin. Biomedicine and Pharmacotherapy, 57: 296-300. (Pubitemid 37123101)
12. Green, LC, Wagner, DA, Glogowski, J, Skipper, PL, Wishnok, JS, and, Tannenbaum, SR. 1982. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Analytical Biochemistry, 126: 131-138. (Pubitemid 13203451)
13. Guengerich, FP, Sorrells, JL, Schmitt, S, Krauser, JA, Aryal, P, and, Meijer, L. 2004. Generation of new protein kinase inhibitors utilizing cytochrome P450 mutant enzymes for indigoid synthesis. Journal of Medicinal Chemistry, 47 (12): 3236-3241. (Pubitemid 38702715)
14. Hajri, A, Metzger, E, Vallat, F, Coffy, S, Flatter, E, and, Evrard, S. 1998. Role of nitric oxide in pancreatic tumour growth: in vivo and in vitro studies. British Journal of Cancer, 78: 841-849. (Pubitemid 28430011)
15. Hibbs, JB Jr. 2002. Infection and nitric oxide. The Journal of Infectious Diseases, 185: S9-S17.
16. Jagetia, GC, and, Baliga, MS. 2006. Evaluation of anticancer activity of the alkaloid fraction of Alstonia scholaris (Sapthaparna) in vitro and in vivo. Phytotherapy Research, 20: 103-109. (Pubitemid 43266833)
17. Kalinowski, HO, Berger, S, and, Braun, S. 1988. Carbon-13 NMR spectroscopy, Chichester: John Wiley & Sons.
18. Kam, TS, and, Sim, KM. 2003. Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa. Phytochemistry, 63: 625-629.
19. Krech, RL, Davis, J, Walsh, D, and, Curtis, EB. 1992. Symptoms of lung cancer. Journal of Palliative Medicine, 6: 309-315.
20. Laskin, DL, and, Laskin, JD. 2001. Role of macrophages and inflammatory mediators in chemically induced toxicity. Toxicology, 160: 111-118. (Pubitemid 32200471)
21. Leone, AM, Palmer, RM, Knowles, RG, Francis, PL, Ashton, DS, and, Moncada, S. 1991. Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. The Journal of Biological Chemistry, 266: 23790-23795. (Pubitemid 21908866)
22. Lind, DS, Kontaridis, MI, Edwards, PD, Josephs, MD, Moldawer, LL, and, Copeland, EM. 1997. Nitric oxide contributes to adriamycin's antitumor effect. The Journal of Surgical Research, 69: 283-287. (Pubitemid 27317869)
23. Liu, RH. 2004. Potential synergy of phytochemicals in cancer prevention: mechanism of action. Journal of Nutrition, 134: 3479S-3485S. (Pubitemid 39587593)
24. Locksley, RM, Killeen, N, and, Lenardo, MJ. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell, 104: 487-501. (Pubitemid 32201945)
25. Lopes, FCM, Benzatti, FP, Jordo, CM Jr, Moreira, RRD, and, Carlos, IZ. 2005. Effect of the essential oil of Achillea millefollium L. in the production of hydrogen peroxide and tumor necrosis factor-in murine macrophages. Brazilian Journal of Pharmaceutical Sciences, 41: 401-405. (Pubitemid 43251195)
26. Lopes, FCM, Calvo, TR, Vilegas, W, and, Carlos, IZ. 2005. Inhibition of hydrogen peroxide, nitric oxide and TNF-production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa. Biological Pharmaceutical Bulletin, 28: 1726-1730. (Pubitemid 41324141)
27. Maugard, T, Enaud, E, Choisy, P, and, Legoy, MD. 2001. Identification of an indigo precursor from leaves of Isatis tinctoria (Woad). Phytochemistry, 58: 897-904. (Pubitemid 33086215)
28. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65: 55-63. (Pubitemid 14203433)
29. Nascimento, FR, Barroqueiro, ES, Azevedo, AP, Lopes, AS, Ferreira, SC, and, Silva, LA. 2006. Macrophage activation induced by Orbignya phalerata Mart. Journal of Ethnopharmacology, 103: 53-58. (Pubitemid 41681141)
30. Nathan, CF. 1987. Secretory products of macrophages. Journal of Clinical Investigation, 79: 319-326. (Pubitemid 17009661)
31. Old, LJ. 1985. Tumor necrosis factor (TNF). Science, 230: 630-632. (Pubitemid 16190956)
32. Pfeffer, K. 2003. Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine and Growth Factor Reviews, 14: 185-191. (Pubitemid 36693140)
33. Phillipson, JD. 2001. Phytochemistry and medicinal plants. Phytochemistry, 56: 237-243. (Pubitemid 32162796)
34. Réthy, B, Hohmann, J, Minorics, R, Varga, A, Ocsovszki, I, and, Molnár, J. 2008. Antitumour properties of acridone alkaloids on a murine lymphoma cell line. Anticancer Research, 28: 2737-2743.
35. Schiller, M, Metze, D, Luger, TA, Grabbe, S, and, Gunzer, M. 2006. Immune response modifiers: Mode of action. Experimental Dermatology, 15: 331-341. (Pubitemid 44056479)
36. Sloan, FA, and, Gelband, A. 2007. Cancer control opportunities in low-and middle-income countries, Washington, DC: The National Academies Press.
37. Stuehr, DJ, and, Nathan, CFA. 1989. Macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. Journal of Experimental Medicine, 169: 1543-1555. (Pubitemid 19126814)
38. Suffredini, IB, Varella, AD, and, Younes, RN. 2006. Cytotoxic molecules from natural sources: tapping the Brazilian biodiversity. Anti-Cancer Agents in Medicinal Chemistry, 6: 367-375.
39. Swann, JB, and, Smyth, MJ. 2007. Immune surveillance of tumors. Journal of Clinical Investigation, 117: 1137-1146. (Pubitemid 46718398)
40. Vallance, P, and, Moncada, S. 1994. Nitric oxide-from mediator to medicines. Journal of the Royal College of Physicians of London, 28: 209-219. (Pubitemid 24171081)
41. Vilcek, J, and, Lee, TH. 1991. Tumor necrosis factor: new insights into the molecular mechanisms of its multiple actions. The Journal of Biological Chemistry, 266: 7313-7316. (Pubitemid 21906368)
42. Wagner, HM, Bladt, S, and, Zgainski, EM. 1986. Planta drug analysis, Berlin: Springer.
43. Wallach, D, Varfolomeev, EE, Malinin, NL, Goltsev, YV, Kovalenko, AV, and, Boldin, MP. 1999. Tumor necrosis factor receptor and Fas signaling mechanisms. Annual Reviews of Immunology, 17: 331-367. (Pubitemid 29241128)
44. Williams, JE. 2001. Review of antiviral and immunomodulating properties of plants of the peruvian rainforest with a particular emphasis on Ua de Gato and Sangre de Grado. Alternative Medicine Review: A Journal of Clinical Therapeutics, 6: 567-579. (Pubitemid 34038812)