Serum Levels of Alanine Aminotransferase Decrease With Age in Longitudinal Analysis

Clinical Gastroenterology and Hepatology

Volumn 10, Issue 3, 2012, Pages

  Dong, Mamie H ^a   Bettencourt, Ricki ^b   Brenner, David A ^a   Barrett Connor, Elizabeth ^b   Loomba, Rohit ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diagnostic; Elderly; Liver Damage; Serum Transaminase

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; BILIRUBIN;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CONTROLLED STUDY; DATA ANALYSIS; DEMOGRAPHY; FEMALE; HUMAN; LIVER FUNCTION TEST; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METABOLISM;

EID: 84857189403     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2011.10.014     Document Type: Article

References (30)

1. Prati D., Taioli E., Zanella A., et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002, 137:E1-E10.
2. Piton A., Poynard T., Imbert-Bismut F., et al. Factors associated with serum alanine transaminase activity in healthy subjects: consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C. Hepatology 1998, 27:1213-1219.
3. Kariv R., Leshno M., Beth-Or A., et al. Re-evaluation of serum alanine aminotransferase upper limit and its modulation factors in a large-scale population study. Liver Int 2006, 26:445-450.
4. Ruhl C.E., Everhart J.E. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003, 124:71-79.
5. Leclercq I., Horsmans Y., De Bruyere M., et al. Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors. Acta Gastroenterol Belg 1999, 62:16-20.
6. Liangpunsakul S., Chalasani N. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the Third National Health and Nutrition Survey (NHANES III). Am J Med Sci 2005, 329:111-116.
7. Ioannou G.N., Boyko E.J., Lee S.P. The prevalence and predictors of elevated serum aminotransferase activity in the United States in 19992002. Am J Gastroenterol 2006, 101:76-82.
8. Patt C.H., Yoo H.Y., Dibadj K., et al. Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program. Dig Dis Sci 2003, 48:797-801.
9. Chen Z.W., Chen L.Y., Dai H.L., et al. Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. J Zhejiang Univ Sci B 2008, 9:616-622.
10. Khedmat H., Fallahian F., Abolghasemi H., et al. Serum γ-glutamyltransferase, alanine aminotransferase, and aspartate aminotransferase activity in Iranian healthy blood donor men. World J Gastroenterol 2007, 13:889-894.
11. Liu C.M., Tung T.H., Liu J.H., et al. A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan. World J Gastroenterol 2005, 11:1616-1622.
12. Loomba R., Bettencourt R., Barrett-Connor E. Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo Study. Aliment Pharmacol Ther 2009, 30:1137-1149.
13. Loomba R., Hwang S.-J., O'Donnell C.J., et al. Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham Heart Study. Gastroenterology 2008, 134:953-959.
14. Hall K.E., Proctor D.D., Fisher L., et al. American Gastroenterology Association Future Trends Committee report: effects of aging of the population on gastroenterology practice, education, and research. Gastroenterology 2005, 129:1305-1338.
15. Mohamadnejad M., Pourshams A., Malekzadeh R., et al. Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors. World J Gastroenterol 2003, 9:2322-2324.
16. Elinav E., Ben-Dov I.Z., Ackerman E., et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol 2005, 100:2201-2204.
17. Le Couteur D.G., Blyth F.M., Creasey H.M., et al. The association of alanine transaminase with aging, frailty, and mortality. J Gerontol A Biol Sci Med Sci 2010, 65:712-717.
18. Dong M.H., Bettencourt R., Barrett-Connor E., et al. Alanine aminotransferase decreases with age: the Rancho Bernardo study. PLoS ONE 2010, 5:e14254.
19. Barrett-Connor E.L., Cohn B.A., Wingard D.L., et al. Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men?. The Rancho Bernardo Study. JAMA 1991, 265:627-631.
20. Barrett-Connor E., Wingard D.L., Criqui M.H. Postmenopausal estrogen use and heart disease risk factors in the 1980s. Rancho Bernardo, Calif, revisited. JAMA 1989, 261:2095-2100.
21. The hypertension detection and follow-up program: hypertension detection and follow-up program cooperative group. Prev Med 1976, 5:207-215. Writing Committee on behalf of the HDFP Cooperative Group.
22. Mofrad P., Contos M.J., Haque M., et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003, 37:1286-1292.
23. Calvaruso V., Craxì A. Implication of normal liver enzymes in liver disease. J Viral Hepat 2009, 16:529-536.
24. Gagliano N., Grizzi F., Annoni G. Mechanisms of aging and liver functions. Dig Dis 2007, 25:118-123.
25. Sakai Y., Zhong R., Garcia B., et al. Assessment of the longevity of the liver using a rat transplant model. Hepatology 1997, 25:421-425.
26. Gagliano N., Arosio B., Grizzi F., et al. Reduced collagenolytic activity of metalloproteinases and development of liver fibrosis in the aging rat. Mech Ageing Dev 2002, 123:413-425.
27. Schmucker D.L. Aging and the liver: an update. J Gerontol A Biol Sci Med Sci 1998, 53:B315-B320.
28. McLean A.J., Cogger V.C., Chong G.C., et al. Age-related pseudocapillarization of the human liver. J Pathol 2003, 200:112-117.
29. Wakabayashi H., Nishiyama Y., Ushiyama T., et al. Evaluation of the effect of age on functioning hepatocyte mass and liver blood flow using liver scintigraphy in preoperative estimations for surgical patients: comparison with CT volumetry. J Surg Res 2002, 106:246-253.
30. Elinav E., Ackerman Z., Maaravi Y., et al. Low alanine aminotransferase activity in older people is associated with greater long-term mortality. J Am Geriatr Soc 2006, 54:1719-1724.