Alanine aminotransferase decreases with age: The Rancho Bernardo study

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Dong, Mamie H ^a   Bettencourt, Ricki ^b   Barrett Connor, Elizabeth ^b   Loomba, Rohit ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; ALBUMIN; BILIRUBIN; BIOLOGICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; GHRELIN; INTERLEUKIN 6; LEPTIN; ALBUMINOID;

ADULT; AGED; AGING; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; COMMUNITY LIVING; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; FEMALE; GENDER; HUMAN; LIVER FUNCTION TEST; MALE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; OBESITY; REGRESSION ANALYSIS; UNITED STATES; ADIPOSE TISSUE; AGE; BIOSYNTHESIS; COHORT ANALYSIS; LIVER DISEASE; METABOLISM; MIDDLE AGED;

ADIPONECTIN; ADIPOSE TISSUE; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ALANINE TRANSAMINASE; ALBUMINS; BILIRUBIN; CALIFORNIA; COHORT STUDIES; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; GHRELIN; HUMANS; INTERLEUKIN-6; LEPTIN; LIVER DISEASES; MALE; MIDDLE AGED;

EID: 78650089490     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014254     Document Type: Article

References (48)

1. Piton A, Poynard T, Imbert-Bismut F, Khalil L, Delattre J, et al. (1998) Factors associated with serum alanine transaminase activity in healthy subjects: Consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C. Hepatology 27: 1213-1219.
2. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, et al. (2002) Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 137: E1-10.
3. Kariv R, Leshno M, Beth-Or A, Strul H, Blendis L, et al. (2006) Re-evaluation of serum alanine aminotransferase upper limit and its modulation factors in a large-scale population study. Liver International 26: 445-450.
4. Ruhl CE, Everhart JE (2003) Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 124: 71-79.
5. Leclercq I, Horsmans Y, De Bruyere M, Geubel AP (1999) Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors. Acta Gastroenterol Belg 62: 16-20.
6. Liangpunsakul S, Chalasani N (2005) Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: Results from the third national health and nutrition survey (NHANES III). Am J Med Sci 329: 111-116.
7. Ioannou GN, Boyako EJ, Lee SP (2006) The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002. Am J Gastroenterol 101: 76-72.
8. Patt CH, Yoo HY, Dibadj K, Flynn J, Thuluvath PJ (2003) Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program. Dig Dis Sci 48: 797-801.
9. Chen Z-W, Chen L-Y, Dai H-L, Chen J-H, Fang L-Z (2008) Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. Journal of Zhejiang University Science B 9: 616-622.
10. Khedmat H, Fallahian F, Abolghasemi H, Hajibeigi B, Attarchi Z, et al. (2007) Serum c-glutamyltransferase, alanine aminotransferase, and aspartate aminotransferase activity in Iranian healthy blood donor men. World J Gastroenterol 13: 889-894.
11. Liu C-M, Tung T-H, Liu J-H, Chen VT-K, Lin C-H, et al. (2005) A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan. World J Gastroenterol 11: 1616-1622.
12. Loomba R, Bettencourt R, Barrett-Connor E (2009) Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: The Rancho Bernardo Study. Aliment Pharmacol Ther 30: 1137-1149.
13. Loomba R, Hwang S-J, O'Donnell CJ, Ellison RC, Vasan RS, et al. (2008) Parental obesity and offspring serum alanine and aspartate aminotransferase levels: The Framingham Heart Study. Gastroenterol 134: 953-959.
14. Hall KE, Proctor DD, Fisher L, Rose S (2005) American Gastroenterology Association Future Trends Committee Report: Effects of aging of the population on gastroenterology practice, education, and research. Gastroenterology 129: 1305-1338.
15. Mohamadnejad M, Pourshams A, Malekzadeh R, Mohamadkhani A, Rajabiani A, et al. (2003) Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors. World J Gastroenterol 9: 2322-2324.
16. Elinav E, Ben-Dov IZ, Ackerman E, Kiderman A, Glikberg F, et al. (2005) Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol 100: 2201-2204.
17. Le Couteur DG, Blyth FM, Creasey HM, Handelsman DJ, Naganathan V, et al. (2010) The association of alanine transaminase with aging, frailty, and mortality. J Gerontol A Biol Sci Med Sci 65: 712-717.
18. Barrett-Conner EL, Cohn BA, Wingard DL, Edelstein SL (1991) Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. JAMA 265: 627-631.
19. Barrett-Conner E, Wingard DL, Criqui MH (1989) Postmenopausal estrogen use and heart disease risk factors in the 1980s. Rancho Bernardo, Calif, revisited. JAMA 261: 2095-2100.
20. The hypertension detection and follow-up program: Hypertension detection and follow-up program cooperative group (1976) Prev Med 5: 207-215.
21. Langenberg C, Bergstrom J, Scheidt-Nave C, Pfeilschifter J, Barrett-Connor E (2006) Cardiovascular death and the metabolic syndrome: Role of adiposity signaling-hormones and inflammatory markers. Diabetes Care 29: 1363-1369.
22. Langenberg C, Bergstrom J, Laughlin GA, Barrett-Conner E (2005) Ghrelin, adiponectin, and leptin do not predict long-term changes in weight and body mass index in older adults: longitudinal analysis of the Rancho Bernardo cohort. Am J Epidemiol 162: 1189-1197.
23. Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, et al. (2003) Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 88: 4823-4831.
24. Choi KM, Lee J, Lee KW, Seo JA, Oh JH, et al. (2004) The associations between plasma adiponectin, ghrelin levels and cardiovascular risk factors. Eur J Endocrinol 150: 715-718.
25. Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, et al. (2004) Serum leptin concentrations and body adipose measures in older black and white adults. Am J Clin Nutr 80: 576-583.
26. Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, et al. (2005) Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 111: 747-753.
27. Tarantino G, Lobello R, Scopacasa F, Contaldo F, Pasanisi F, et al. (2007) The contribution of omental adipose tissue to adipokine concentrations in patients with the metabolic syndrome. Clin Invest Med 30: E192-199.
28. Qi L, Zhang C, van Dam RM, Hu FB (2007) Interleukin-6 genetic variability and adiposity: association in two prospective cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab 92: 3618-3625.
29. Kamade Y, Nakamura T, Funahashi T, Ryo M, Nishizawa H, et al. (2009) Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction. J Clin Gastroenterol 43: 995-1000.
30. Lu JY, Su TC, Liu YH, Hsu HJ, Chen CL, et al. (2007) Lower plasma adiponectin is correlated to higher alanine aminotransferase independent of metabolic factors and hepatitis B virus carrier status. Intern Med J 37: 365-371.
31. Davies JS, Kotokorpi P, Eccles SR, Barnes SK, Tokarczuk PF, et al. (2009) Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol 23: 914-924.
32. Carlson JJ, Turpin AA, Wiebke G, Hunt SC, Adams TD (2009) Pre- and postprandial appetite hormone levels in normal weight and severely obese women. Nutr Metab 6: 32.
33. Arndt V, Brenner H, Rothenbacher D, Zschenderlein B, Fraisse E, et al. (1998) Elevated liver enzyme activity in construction workers: prevalence and impact on early retirement and all-cause mortality. Int Arch Occup Environ Health 71: 405-412.
34. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, et al. (2005) The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 129: 113-121.
35. Coleman PJ, McQuillan GM, Moyer LA, Lambert SB, Margolis HS (1998) Incidence of hepatitis B virus infection in the United States, 1976-1994: Estimates from the National Health and Nutrition Examination Surveys. J Infect Dis 178: 954-959.
36. Alter MJ, Kruszon-Moran D, Nainan OV, McQuillan GM, Gao F, et al. (1999) The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 341: 556-562.
37. Gagliano N, Grizzi F, Annoni G (2007) Mechanisms of aging and liver functions. Dig Dis 25: 118-123.
38. Sakai Y, Zhong R, Garcia B, Zhu L, Wall WJ (1997) Assessment of the longevity of the liver using a rat transplant model. Hepatology 25: 421-425.
39. Gagliano N, Arosio B, Grizzi F, Masson S, Tagliabue J, et al. (2002) Reduced collagenolytic activity of metalloproteinases and development of liver fibrosis in the aging rat. Mech Ageing Dev 123: 413-425.
40. Schmucker DL (1998) Aging and the liver: an update. J Gerontol A Biol Sci Med Sci 53: B315-320.
41. McLean AJ, Cogger VC, Chong GC, Warren A, Markus AM, et al. (2003) Agerelated pseudocapillarization of the human liver. J Pathol 200: 112-117.
42. Wakabayashi H, Nishiyama Y, Ushiyama T, Maeba T, Maeta H (2002) Evaluation of the effect of age on functioning hepatocyte mass and liver blood flow using liver scintigraphy in preoperative estimations for surgical patients: comparison with CT volumetry. J Surg Res 106: 246-253.
43. Elinav E, Ackerman Z, Maaravi Y, Ben-Dov IZ, Ein-Mor E, et al. (2006) Low alanine aminotransferase activity in older people is associated with greater longterm mortality. J Am Geriatr Soc 54: 1719-1724.
44. Mofrad P, Contos MJ, Haque M, Sargeant C, Fisher RA, et al. (2003) Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 37: 1286-1292.
45. Calvaruso V, Craxi A (2009) Implication of normal liver enzymes in liver disease. J Viral Hepat 16: 529-536.
46. Frith J, Day CP, Henderson E, Burt AD, Newton JL (2009) Non-alcoholic fatty liver disease in older people. Gerontology 55: 607-613.
47. Angulo P, Keach JC, Batts KP, Lindor KD (1999) Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30: 1356-1362.
48. Miyaaki H, Ichikawa T, Nakao K, Yatsuhashi H, Furukawa R, et al. (2008) Clinicopathological study of nonalcoholic fatty liver disease in Japan: the risk factors for fibrosis. Liver Int 28: 519-524.