The association of alanine transaminase with aging, frailty, and mortality

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 65 A, Issue 7, 2010, Pages 712-717

  Le Couteur, David G ^a   Blyth, Fiona M ^a,b   Creasey, Helen M ^a   Handelsman, David J ^a   Naganathan, Vasi ^a   Sambrook, Philip N ^a   Seibel, Markus J ^a   Waite, Louise M ^a   Cumming, Robert G ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Aging; Alanine transaminase; Biomarker of aging; Frailty; Liver; Mortality

Indexed keywords

ALANINE AMINOTRANSFERASE; BIOLOGICAL MARKER; SERUM ALBUMIN;

AGE; AGED; AGING; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; BODY MASS; CONFIDENCE INTERVAL; DRINKING BEHAVIOR; FRAIL ELDERLY; HUMAN; KAPLAN MEIER METHOD; LIVER FUNCTION TEST; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; RISK;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ALANINE TRANSAMINASE; ALCOHOL DRINKING; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BODY MASS INDEX; CONFIDENCE INTERVALS; FRAIL ELDERLY; HUMANS; KAPLAN-MEIERS ESTIMATE; LIVER FUNCTION TESTS; MALE; MORTALITY; MULTIVARIATE ANALYSIS; ODDS RATIO; PROPORTIONAL HAZARDS MODELS; SERUM ALBUMIN;

EID: 77953969690     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glq082     Document Type: Article

References (23)

1. MArchesini G, Moscatiello S, Di Domizio S, Forlani G. Obesity-associated liver disease. J Clin Endocrinol Metab. 2008;93:S74-S80.
2. Chapman IM. Obesity in old age. Front Horm Res. 2008;36:97-106.
3. Elinav E, Ackerman Z, Maaravi Y, Ben-Dov IZ, Ein-Mor E, Stessman J. Low alanine aminotransferase activity in older people is associated with greater long-term mortality. J Am Geriatr Soc. 2006;54:1719-1724.
4. Schmucker DL. Age-related changes in liver structure and function: implications for disease? Exp Gerontol. 2005;40:650-659.
5. McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharMAcology. Pharmacol Rev. 2004;56:163-184.
6. Le Couteur DG, Sinclair DA, Cogger VC, et al. The aging liver and longterm caloric restriction. In: A everitt, S rattan, DG Le Couteur and r de Cabo (eds). Calorie Restriction, Aging and Longevity. New York: Springer Press; 2010:191-216.
7. Carriere I, Dupuy AM, Lacroux A, Cristol JP, Delcourt C. Biomarkers of infammation and MAlnutrition associated with early death in healthy elderly people. J Am Geriatr Soc. 2008;56:840-846.
8. Corti MC, Guralnik JM, Salive ME, Sorkin JD. Serum albumin level and physical disability as predictors of mortality in older persons. JAMA. 1994;272:1036-1042.
9. Okamura T, Hayakawa T, Hozawa A, et al. Lower levels of serum albumin and total cholesterol associated with decline in activities of daily living and excess mortality in a 12-year cohort study of elderly Japanese. J Am Geriatr Soc. 2008;56:529-535.
10. Crimmins E, Vasunilashorn S, Kim JK, Alley D. Biomarkers related to aging in human populations. Adv Clin Chem. 2008;46:161-216.
11. Elinav E, Ben-Dov IZ, AckerMAn E, et al. Correlation between serum alanine aminotransferase activity and age: an inverted U curve pattern. Am J Gastroenterol. 2005;100:2201-2204.
12. Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S. The current state of serum bioMArkers of hepatotoxicity. Toxicology. 2008;245:194-205
13. Topinkova E. Aging, disability and frailty. Ann Nutr Metab. 2008;52(suppl 1):6-11.
14. Blyth FM, Rochat S, Cumming RG, et al. Pain, frailty and comorbid-ity on older men: the ChAMP study. Pain. 2008;140:224-230.
15. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56: M146-M156.
16. CaMArgo CA Jr, Hennekens CH, Gaziano JM, Glynn RJ, Manson JE, Stampfer MJ. Prospective study of moderate alcohol consumption and mortality in US MAle physicians. Arch Intern Med. 1997;157:79-85.
17. McAuley P, Myers J, Abella J, Froelicher V. Body MAss, ftness and survival in veteran patients: another obesity paradox? Am J Med. 2007;120:518-524.
18. Zamboni M, MAzzali G, Zoico E, et al. health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond). 2005;29:1011-1029.
19. Fraser A, Thinggaard M, Christensen K, Lawlor DA. Alanine amin-otransferase, gamMA-glutamyltransferase (GGT) and all-cause mortality: results from a population-BAsed Danish twins study alanine aminotransferase, GGT and mortality in elderly twins. Liver Int. 2009;29:1494-1499.
20. Santos-Eggimann B, Cuenoud P, Spagnoli J, Junod J. Prevalence of frailty in middle-aged and older community-dwelling europeans living in 10 countries. J Gerontol A Biol Sci Med Sci. 2009;64:675-681.
21. Schalk BW, Visser M, Deeg DJ, Bouter LM. Lower levels of serum albumin and total cholesterol and future decline in functional perforMAnce in older persons: the Longitudinal Aging Study Amsterdam. Age Ageing. 2004;33:266-272.
22. Reuben DB, Ix JH, Greendale GA, Seeman TE. The predictive value of combined hypoalbuminemia and hypocholesterolemia in high functioning community-dwelling older persons: MAcArthur Studies of Successful Aging. J Am Geriatr Soc. 1999;47:402-406.
23. Kanapuru B, Ershler WB. Infammation, coagulation, and the pathway to frailty. Am J Med. 2009;122:605-613.