The prevalence and predictors of elevated serum aminotransferase activity in the United States in 1999-2002

American Journal of Gastroenterology

Volumn 101, Issue 1, 2006, Pages 76-82

  Ioannou, George N ^a,b   Boyko, Edward J ^a,b   Lee, Sum P ^a,b  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HEPATITIS C ANTIBODY;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; AMINOTRANSFERASE BLOOD LEVEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; CONTROLLED STUDY; DIAGNOSTIC TEST; ENZYME ACTIVITY; ETHNOLOGY; FEMALE; HEALTH SURVEY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; NONALCOHOLIC FATTY LIVER; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK FACTOR; UNITED STATES; WAIST CIRCUMFERENCE; AGE DISTRIBUTION; ARTICLE; BLOOD; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; HOSPITALIZATION; LIVER DISEASE; LIVER FUNCTION TEST; MIDDLE AGED; PREDICTION AND FORECASTING; SEX RATIO;

ADULT; AGE DISTRIBUTION; AGED; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PREVALENCE; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; UNITED STATES;

EID: 33644854337     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.00341.x     Document Type: Review

References (15)

1. Clark JM Brancati FL Diehl AM The prevalence and etiology of elevated aminotransferase levels in the United States Am J Gastroenterol 2003 98 960 7
2. Ruhl CE Everhart JE Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States Gastroenterology 2003 124 71 9
3. Daniel S Ben-Menachem T Vasudevan G et al Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients Am J Gastroenterol 1999 94 3010 4
4. Skelly MM James PD Ryder SD Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology J Hepatol 2001 35 195 9
5. Ratziu V Giral P Charlotte F et al Liver fibrosis in overweight patients Gastroenterology 2000 118 1117 23
6. Gunter EW Lewis BG Koncikowski SM Laboratory procedures used for the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Environmental Health Atlanta GA and National Center for Health Statistics Hyattsville MD 1996
7. Williams KM Williams AE Kline LM et al Stability of serum alanine aminotransferase activity Transfusion 1987 27 431 3
8. Flegal KM Carroll MD Ogden CL et al Prevalence and trends in obesity among US adults, 1999-2000 JAMA 2002 288 1723 7
9. NHANES Analytic Guidelines, June 2004 Version Available at
10. NHANES 1999-2000 Public Data Release (June 2002) Laboratory 18-Standard biochemistry profile, follicle stimulating hormone, and luteinizing hormone. Available at
11. NHANES 2001-2002 Data Release, May 2004, Documentation for Laboratory Results Laboratory 18 and 40-Standard biochemistry profile, follicle stimulating hormone, and luteinizing hormone. Available at
12. Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988-1994 U.S. Department of Health and Human Services, Public Health Services, Centers for Disease Control and Prevention, National Center for Health Statistics Hyattsville MD 1994
13. Ruhl CE Everhart JE Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States Gastroenterology 2003 124 1821 9
14. Browning JD Szczepaniak LS Dobbins R et al Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity Hepatology 2004 40 1387 95
15. Ioannou GN Weiss NS Boyko EJ et al Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease Gastroenterology 2005 128 627 35