Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-β

Cancer Letters

Volumn 107, Issue 1, 1996, Pages 37-44

  Shidaifat, Falah ^a   Canatan, Halit ^a   Kulp, Samuel K ^a   Sugimoto, Yasuro ^a   Chang, William Y ^a   Zhang, Yuan ^a   Brueggemeier, Robert W ^a,b   Somers, William J ^b   Lin, Young C ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Cell cycle; Gossypol; Prostate cancer; Transforming growth factor 1

Indexed keywords

ANTIMITOTIC AGENT; CONTRACEPTIVE AGENT; GOSSYPOL; RIBONUCLEASE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL STIMULATION; CONTROLLED STUDY; DNA SYNTHESIS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MALE; METAPHASE; PRIORITY JOURNAL; PROSTATE CANCER;

EID: 0030272536     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04340-6     Document Type: Article

References (33)

1. [1] Steiner, M.S. (1993) Role of peptide growth factors in the prostate: a review, Urology, 42, 99-110.
2. [2] Kyprianou, N. and Isaacs, J.T. (1988) Activation of programmed cell death in the ventral prostate after castration, Endocrinology, 122, 552-562.
3. [3] Kyprianou, N. and Isaacs, J.T. (1989) Expression of transforming growth factor-β in the rat ventral prostate during castration-induced programmed cell death, Mol. Endocrinol., 3, 1515-1522.
4. [4] Kyprianou, N., English, H.F. and Isaacs, J.T. (1990) Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation, Cancer Res., 50, 3748-3753.
5. [5] Scott, W.W., Menon, M. and Walsh, P.C. (1980) Hormonal therapy of prostatic cancer, Cancer, 45, 1929-1936.
6. [6] Isaacs, J.T. (1993) Prostatic cancer: an age-old problem. In: The Underlying Molecular, Cellular, and Immunological Factors in Cancer and Aging, pp. 167-184. Editors: S.S. Yang and H.R. Warner. Plenum Press, New York.
7. [7] Kalla, N.R., Rovan, E., Ranga, A. and Frick, J. (1985) Effect of gossypol on immature male rats, Acta Eur. Fertil., 16, 437-446.
8. [8] Ranga, A., Kalla, N.R. and Kanwar, U. (1990) Effect of gossypol on the fertility of male rats, Acta Eur. Fertil., 21, 7-12.
9. [9] Lin, Y.C., Chang, C.J.G., Moh, P.P. and Brueggemeier, R.W. (1992) Inhibitory action of gossypol on rat prostate, FASEB J., 6, A2031.
10. [10] Wong, Y.C. and Tam, C.C. (1989) Structural changes of the guinea pig prostatic epithelial cells after gossypol treatment, Acta Anat., 134, 18-25.
11. [11] Moh, P.P., Chang, C.J.G., Brueggemeier, R.W. and Lin, Y.C. (1993) Effect of gossypol on 5α-reductase and 3α-hydroxysteroid dehydrogenase activities in adult rat testes, Res. Commun. Chem. Pathol. Pharmacol., 82, 12-26.
12. [12] Lee, C.Y.G., Moon, Y.S., Yuan, J.H. and Chen, A.F. (1982) Enzyme inactivation and inhibition by gossypol, Mol. Cell. Biochem., 47, 65-70.
13. 2+-dependent protein kinase from pig testis, Biochim. Biophys. Acta, 839, 276-280.
14. [14] Adlakha, R.C., Ashorn, C.L., Chan, D. and Zwelling, L.A. (1989) Modulation of 4′-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol, Cancer Res., 49, 2052-2058.
15. [15] Rosenberg, L.J., Adlakha, R.C., Desai, D.M. and Rao, P.N. (1986) Inhibition of DNA polymerase-α by gossypol, Biochim. Biophys. Acta, 866, 258-267.
16. [16] Hu, Y.F., Chang, C.J.G., Brueggemeier, R.W. and Lin, Y.C. (1993) Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells, Life Sci., 53, 433-438.
17. [17] Hu, Y.F., Chang, C.J.G., Brueggemeier, R.W. and Lin, Y.C. (1994) Presence of antitumor activities in the milk collected from gossypol-treated dairy cows, Cancer Lett., 87, 17-23.
18. 31P nuclear magnetic resonance and toxicity studies, Cancer Res., 50, 6936-6943.
19. [19] Tuszynski, G.P. and Cossu, G. (1984) Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma and other tissue culture cell lines, Cancer Res., 44, 768-771.
20. [20] Thomas, M., Von Hagen, V., Moustafa, Y., Montmasson, M.P. and Monet, J.D. (1991) Effects of gossypol on the cell cycle phases in T47-D human breast cancer cells, Anticancer Res., 11, 1469-1476.
21. [21] Wang, Y. and Rao, P.N. (1984) Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro, Cancer Res., 44, 35-38.
22. [22] Wu, Y.W., Chik, C.L. and Knazek, R.A. (1989) An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma, Cancer Res., 49, 3754-3758.
23. [23] Coyle, T., Levante, S., Shetler, M. and Winfield, J. (1994) In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines, J. Neurooncol., 19, 25-35.
24. [24] Tso, W.W. (1984) Gossypol inhibits Ehrlich ascites tumor cell proliferation, Cancer Lett., 24, 257-261.
25. [25] Flack, M.R., Pyle, R.G., Mullen, N.M., Lorenzo, B., Wu, Y.W., Knazek, R.A., Nisula, B.C. and Reidenberg, M.M. (1993) Oral gossypol in the treatment of metastatic adrenal cancer, J. Clin. Endocrinol. Metab., 76, 1019-1024.
26. [26] Chang, C.J.G., Ghosh, P.K., Hu, Y.F., Brueggemeier, R.W. and Lin, Y.C. (1993) Antiproliferative and antimetastatic effect of gossypol on Dunning prostate cell-bearing Copenhagen rats, Res. Commun. Chem. Pathol. Pharmacol., 76, 293-312.
27. [27] Derynck, R., Goeddel, D.V., Ullrich, A., Gutterman, J.U., Williams, R.D., Bringman, T.S. and Berger, W.H. (1987) Synthesis of messenger RNAs for transforming growth factor a and β and the epidermal growth factor receptor by human tumors, Cancer Res., 47, 707-712.
28. [28] Ikeda, T., Lioubin, M.N. and Marqardt, H. (1987) Human transforming growth factor type β2: production by prostatic adenocarcinoma cell line, purification, and initial characterization, Biochemistry, 26, 2406-2410.
29. [29] Wilding, G., Zugmeier, G., Knabbe, C., Flanders, K. and Gelmann, E. (1989) Differential effect of transforming growth factor β on human prostate cancer cells in vitro, Mol. Cell. Endocrinol., 62, 79-87.
30. [30] Alexandrow, M.G. and Moses, H.L. (1995) Transforming growth factor β and cell cycle regulation, Cancer Res., 55, 1452-1457.
31. [31] Sehy, D.W., Shao, L.E., Yu, A.L., Tsai, W.M. and Yu, J. (1992) Activin-A-induced differentiation in K562 cells is associated with transient hypophosphorylation of RB protein and the concomitant block of cell cycle at the G1 phase, J. Cell. Biochem., 50, 225-256.
32. [32] Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction, Anal. Biochem., 162, 156-159.
33. [33] Isaacs, J.T. and Coffey, D.S. (1981) Adaption versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation as studied in the Dunning R-3327 H adenocarcinoma, Cancer Res., 41, 500-507.