Differences in MEF2 and NFAT transcriptional pathways according to human heart failure aetiology

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Cortés, Raquel ^a   Rivera, Miguel ^a   Roselló Lletí, Esther ^a   Martínez Dolz, Luis ^a   Almenar, Luis ^a   Azorín, Inmaculada ^a   Lago, Francisca ^b   González Juanatey, José Ramón ^b   Portolés, Manuel ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b Pediatric Nutrition Research Group Health Research Institute of Santiago de Compostela   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CALMODULIN; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2C; NUCLEAR FACTOR OF ACTIVATED T CELLS 1; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; ATP2A2 PROTEIN, HUMAN; CALCIUM; GATA4 PROTEIN, HUMAN; MADS DOMAIN PROTEIN; MEF2C PROTEIN, HUMAN; MYOGENIC FACTOR; NFATC2 PROTEIN, HUMAN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGER 1; SODIUM-CALCIUM EXCHANGER 1;

ADULT; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL FEATURE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; FEMALE; FLUORESCENCE MICROSCOPY; HEART FAILURE; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; ISCHEMIC CARDIOMYOPATHY; MALE; MOLECULAR PATHOLOGY; OUTCOME ASSESSMENT; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; WESTERN BLOTTING; CELL FRACTIONATION; ECHOGRAPHY; ELECTROCARDIOGRAPHY; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; HEART MUSCLE; HEART MUSCLE CELL; HETEROCHROMATIN; METABOLISM; MIDDLE AGED; PATHOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

BLOTTING, WESTERN; CALCINEURIN; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CALMODULIN; ELECTROCARDIOGRAPHY; FEMALE; GATA4 TRANSCRIPTION FACTOR; HEART FAILURE; HETEROCHROMATIN; HUMANS; MADS DOMAIN PROTEINS; MALE; MIDDLE AGED; MYOCARDIUM; MYOCYTES, CARDIAC; MYOGENIC REGULATORY FACTORS; NFATC TRANSCRIPTION FACTORS; PROTEIN TRANSPORT; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; SODIUM-CALCIUM EXCHANGER; SUBCELLULAR FRACTIONS; TRANSCRIPTION, GENETIC;

EID: 84857178202     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030915     Document Type: Article

References (33)

1. Cohn JN, Ferrari R, Sharpe N, (2000) Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 35: 569-582.
2. Hill JA, Olson EN, (2008) Cardiac plasticity. N Engl J Med 358: 1370-80.
3. Sadoshima J, Izumo S, (1997) The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59: 551-571.
4. Beuckelmann DJ, Näbauer M, Erdmann E, (1992) Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 85: 1046-1055.
5. Hasenfuss G, Pieske B, (2002) Calcium cycling in congestive heart failure. J Mol Cell Cardiol 34: 951-969.
6. Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, et al. (2000) Ca2+/Calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1 induced cardiomyocytes hypertrophy. J Biol Chem 275: 15239-15245.
7. Bueno OF, van Rooij E, Molkentin JD, Doevendans PA, De Windt LJ, (2002) Calcineurin and hypertrophic heart disease: novel insights and remaining questions. Cardiovasc Res 53: 806-821.
8. Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, et al. (2003) Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocytes Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res 92: 904-911.
9. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, et al. (1998) A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228.
10. Kapiloff MS, Mathis JM, Nelson CA, Lin CR, Rosenfeld MG, (1991) Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation. Proc Natl Acad Sci U S A 88: 3710-3714.
11. Barry SP, Townsend PA, (2010) What causes a broken heart-molecular insights into heart failure. Int Rev Cell Mol Biol 284: 113-179.
12. Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, et al. (2002) Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110: 479-488.
13. Passier R, Zheng H, Frey N, Naya FJ, Nicol RL, et al. (2000) CaM Kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. J Clin Invest 105: 1395-1406.
14. Little GH, Bai Y, Williams T, Poizat C, (2007) Nuclear calcium/calmodulin-dependent protein kinase II delta preferentially transmits signals to histone deacetylase 4 in cardiac cells. J Biol Chem 282: 7219-7231.
15. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, et al. (2004) Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 94: 110-118.
16. Mishra S, Sabbah HN, Jain JC, Gupta RC, (2003) Reduced Ca2+/calmodulin-dependent protein kinase activy and expression in LV myocardium of dogs with heart failure. Am J Physiol Heart Circ Physiol 284: H876-H873.
17. Hoch B, Meyer R, Hetzer R, Krause EG, Karczewski P, (1999) Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res 84: 713-721.
18. Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, et al. (2005) Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J 26: 1115-1140.
19. Cortés R, Roselló-Lletí E, Rivera M, Martínez-Dolz L, Salvador A, et al. (2010) Influence of heart failure on nucleocytoplasmic transport in human cardiomyocytes. Cardiovasc Res 85: 464-472.
20. Peterson GL, (1977) A simplification of the protein assay method of Lowryet al. which is more generally applicable. Anal Biochem 83: 346-56.
21. Hasenfuss G, (1998) Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res 37: 279-289.
22. Frank KF, Bölck B, Erdmann E, Schwinger RH, (2003) Sarcoplasmic reticulum Ca2+-ATPasa modulates cardiac contraction and relaxation. Cardiovasc Res 57: 20-27.
23. Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, et al. (2010) Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res 107: 1150-1161.
24. Liang Q, De Windt LJ, Witt SA, Kimball TR, Markham BE, et al. (2001) The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem 276: 30245-30253.
25. Ahmad F, Seidman JG, Seidman CE, (2005) The genetic basis for cardiac remodeling. Annu Rev Genomics Hum Genet 6: 185-216.
26. Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, et al. (1999) HDAC4 deacetylase associates with and represses the MEF2 transcription factor. EMBO J 18: 5099-5107.
27. Böhm M, Gierschik P, Jakobs KH, Pieske B, Schnabel P, et al. (1990) Increase in Gi alpha in human hearts with dilated but not ischemic cardiomyopathy. Circulation 82: 1249-1265.
28. Pauschinger M, Doerner A, Remppis A, Tannhäuser R, Kühl U, et al. (1998) Differential myocardial abundance of collagen type I and type III mRNA in dilated cardiomyopathy: effects of myocardial inflammation. Cardiovasc Res 37: 123-9.
29. Jefferies JL, Towbin JA, (2010) Dilated cardiomyopathy. Lancet 375: 752-762.
30. Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, et al. (2009) Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Circ Cardiovasc Genet 2: 212-219.
31. Lu YM, Shioda N, Yamamoto Y, Han F, Fukunaga K, (2010) Transcriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes. Biochem Biophys Acta 1799: 429-441.
32. Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, et al. (2006) Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation 114: 1352-1359.
33. Lynch J, Guo L, Gelebart P, Chilibeck K, Xu J, et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol 170: 37-47.