Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture

Neurochemistry International

Volumn 60, Issue 4, 2012, Pages 335-343

  Du, Fang ^a   Fan, Ming ^b   Gong, Qi ^a   Zhu, Ling Ling ^b   Zhu, Zhou Jing ^a   Lu, Lina ^a   Ke, Ya ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Divalent metal transporter 1 (DMT1); Ferroportin1 (Fpn1); Hypoxia inducible factor 1alpha (HIF 1alpha); Hypoxic preconditioning (HP); Iron influx and iron efflux; Iron transport; Neuroprotection; Primary cultured neurons; Transferrin receptor (TfR1)

Indexed keywords

CD71 ANTIGEN; FERROPORTIN 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN CELL; CELL VIABILITY; CONTROLLED STUDY; IRON KINETICS; IRON METABOLISM; IRON TRANSPORT; ISCHEMIC PRECONDITIONING; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT;

ANIMALS; ANOXIA; BIOLOGICAL TRANSPORT; CELLS, CULTURED; FEMALE; IRON; ISCHEMIC PRECONDITIONING; NEURONS; PREGNANCY; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84857134714     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.01.008     Document Type: Article

References (40)

1. Abboud, S., Haile, D.J., 2000. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275 (26), 19906-19912. (Pubitemid 30441595)
2. Bianchi, L., Tacchini, L., Cairo, G., 1999. HIF-1-mediated activation of transferring receptor gene transcription by iron chelation. Nucleic Acids Res. 27, 4223-4227. (Pubitemid 29500256)
3. Burdo, J.R., Menzies, S.L., Simpson, I.A., Garrick, L.M., Garrick, M.D., Dolan, K.G., Haile, D.J., Beard, J.L., Connor, J.R., 2001. Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J. Neurosci. Res. 66 (6), 1198-1207. (Pubitemid 33135606)
4. Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., Drejer, A., Barut, B., Zapata, A., Law, T.C., Brugnara, C., Lux, S.E., Pinkus, G.S., Pinkus, J.L., Kingsley, P.D., Palis, J., Fleming, M.D., Andrews, N.C., Zon, L.I., 2000. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403, 776-781. (Pubitemid 30111839)
5. Du, F., Qian, Z.M., Zhu, L., Wu, X.M., Yung, W.H., Tsim, T.Y., Ke, Y., 2009. L-DOPA neurotoxicity is mediated by up-regulation of DMT1-IRE expression. PLoS ONE 4 (2), e4593.
6. Du, F., Zhu, L., Qian, Z.M., Wu, X.M., Yung, W.H., Ke, Y., 2010. Hyperthermic preconditioning protects astrocytes from ischemia/reperfusion injury by up-regulation of HIF-1 alpha expression and binding activity. Biochim. Biophys. Acta Mol. Basis Dis. 1802 (11), 1048-1053.
7. Ge, X.H., Wang, Q., Qian, Z.M., Zhu, L., Du, F., Yung, W.H., Yang, L., Ke, Y., 2009. The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes. J. Nutr. Biochem. 20 (11), 805-860.
8. Gidday, J.M., Shah, A.R., Maceren, R.G., Wang, Q., Pelligrino, D.A., Holtzman, D.M., Park, T.S., 1999. Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning. J. Cereb. Blood Flow Metab. 19, 331-340. (Pubitemid 30026923)
9. Gustavsson, M., Anderson, M.F., Mallard, C., Hagberg, H., 2005. Hypoxic preconditioning confers long-term reduction of brain injury and improvement of neurological ability in immature rats. Pediatr. Res. 57 (2), 305-309. (Pubitemid 40165613)
10. Hanson, E.S., Foot, L.M., Leibold, E.A., 1999. Hypoxia post-translationally activates iron-regulatory protein 2. J. Biol. Chem. 274 (8), 5047-5052.
11. Hanson, E.S., Leibold, E.A., 1998. Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation. J. Biol. Chem. 273 (13), 7588-7593. (Pubitemid 28152786)
12. He, W., Qian, Z.M., Zhu, L., Qian, C., Du, F., Yung, W.H., Ke, Y., 2007. Ginkgolides mimic the effects of hypoxic preconditioning to protect C6 cells against ischemic injury by up-regulation of hypoxia-inducible factor-1 alpha and erythropoietin. Int. J. Biochem. Cell Biol. 40, 651-662. (Pubitemid 351288586)
13. Hu, J., Connor, J.R., 1996. Demonstration and characterization of the iron regulatory protein in human brain. J. Neurochem. 67, 838-844. (Pubitemid 26255683)
14. Jeong, S.Y., David, S., 2003. GPI-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J. Biol. Chem. 278 (29), 27144-27148. (Pubitemid 36876870)
15. Jiang, D.H., Ke, Y., Chang, Y.Z., Ho, K.P., Qian, Z.M., 2002. Distribution of ferroportin1 protein in different regions of developing rat brain. Dev. Neurosci. 24 (2-3), 94-98. (Pubitemid 36151438)
16. Ke, Q., Costa, M., 2006. Hypoxia-inducible factor-1 (HIF-1). Mol. Pharmacol. 70, 1469-1480.
17. Ke, Y., Chang, Y.Z., Duan, X.L., Du, J.R., Zhu, L., Wang, K., Yang, X.D., Ho, K.P., Qian, Z.M., 2005. Iron-independent and Age-dependent expression of the two mRNA isoforms of divalent metal transporter 1 in different brain regions of rats. Neurobiol. Aging 26 (5), 739-748. (Pubitemid 40233011)
18. Ke, Y., Qian, Z.M., 2007. Brain iron metabolism: neurobiology and neurochemistry. Prog. Neurobiol. 83 (3), 149-173. (Pubitemid 47484044)
19. Lok, C.N., Ponka, P., 1999. Identification of a hypoxia response element in the transferrin receptor gene. J. Biol. Chem. 274, 24147-24152.
20. Matsushima, K., Hakim, A.M., 1995. Transient forebrain ischemia protects against subsequent focal cerebral ischemia without changing cerebral perfusion. Stroke 26 (6), 1047-1052.
21. McKie, A.T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T.J., Farzaneh, F., Hediger, M.A., Hentze, M.W., Simpson, R.J., 2000. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5 (2), 299-309. (Pubitemid 30628088)
22. Mukhopadhyay, C.K., Mazumder, B., Fox, P.L., 2000. Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J. Biol. Chem. 275 (28), 21048-21054. (Pubitemid 30481794)
23. Murray, C.E., Jennings, R.B., Reimer, K.A., 1986. Preconditioning with ischaemia: a delay of lethal cell injury in ischaemic myocardium. Circulation 74, 1124-1136. (Pubitemid 17174962)
24. Nicolas, G., Chauvet, C., Viatte, L., Danan, J.L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., Vaulont, S., 2002. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110, 1037-1044.
25. Qian, Z.M., Morgan, E.H., 1990. Effect of lead on the transport of transferrin-free and transferrin-bound iron into rabbit reticulocytes. Biochem. Pharmacol. 40 (5), 1049-1054. (Pubitemid 20259710)
26. Qian, Z.M., Morgan, E.H., 1992. Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro. Biochim. Biophys. Acta 1135, 35-43.
27. Qian, Z.M., Tang, P.L., Wang, Q., 1997. Iron crosses the endosomal membrane by a carrier-mediated process. Prog. Biophys. Mol. Biol. 67, 1-15. (Pubitemid 27491747)
28. Qian, Z.M., Wang, Q., 1998. Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders. Brain Res. Rev. 27 (3), 257-267. (Pubitemid 28389311)
29. Qian, Z.M., Shen, X., 2001. Brain iron transport and neurodegeneration. Trends Mol. Med. 7 (3), 103-108. (Pubitemid 32201671)
30. Qian, Z.M., Li, H.Y., Sun, H.Z., Ho, K., 2002. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol. Rev. 54 (4), 561-587. (Pubitemid 35351196)
31. Qian, Z.M., Chang, Y.Z., Leung, G., Du, J.R., Zhu, L., Wang, Q., Niu, L., Xu, Y.J., Yang, L., Ho, K.P., Ke, Y., 2007. Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart. Biochim. Biophys. Acta Mol. Basis Dis. 1772, 527-532. (Pubitemid 46613862)
32. Qian, Z.M., Wu, X.M., Fan, M., Yang, L., Du, F., Yung, W.H., Ke, Y., 2011. Divalent metal transporter 1 is a hypoxia-inducible gene. J. Cell. Physiol. 226, 1596-1603.
33. Ran, R., Xu, H., Lu, A., Bernaudin, M., Sharp, F.R., 2005. Hypoxia preconditioning in the brain. Dev. Neurosci. 27 (2-4), 87-92. (Pubitemid 41096213)
34. Rolfs, A., Kvietikova, I., Gassmann, M., Wenger, R.H., 1997. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J. Biol. Chem. 272, 20055-20062. (Pubitemid 27340110)
35. Stone, T.W., 2003. Pre-conditioning protection in the brain. Br. J. Pharmacol. 140, 229-230. (Pubitemid 37249180)
36. Vannucci, R.C., Towfighi, J., Vannucci, S.J., 1998. Hypoxic preconditioning and hypoxic-ischemic brain damage in the immature rat: Pathologic and metabolic correlates. J. Neurochem. 71, 1215-1220. (Pubitemid 28390276)
37. Wagner, B.P., Nedelcu, J., Martin, E., 2002. Delayed postischemic hypothermia improves long-term behavioral outcome after cerebral hypoxia-ischemia in neonatal rats. Pediatr. Res. 51, 354-360. (Pubitemid 34174973)
38. Wu, L.J., Leenders, A.G., Cooperman, S., Meyron-Holtz, E., Smith, S., Land, W., Tsai, R.Y., Berger, U.V., Sheng, Z.H., Rouault, T.A., 2004. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res. 1001, 108-117. (Pubitemid 38221533)
39. Wu, L.Y., Ding, A.S., Zhao, T., Ma, Z.M., Wang, F.Z., Fan, M., 2005. Underlying mechanism of hypoxic preconditioning decreasing apoptosis induced by anoxia in cultured hippocampal neurons. Neurosignals 14 (3), 109-116. (Pubitemid 41160297)
40. Zhu, L., Lai, Z., Ya, K., Fang, D., Ho, Y.W., Lei, Y., Ming, Q.Z., 2008. Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J. Cell Mol. Med. 12 (2), 569-579. (Pubitemid 351555136)