A mathematical model of tumour and blood pHe regulation: The HCO 3 -/CO 2 buffering system

Mathematical Biosciences

Volumn 230, Issue 1, 2011, Pages 1-11

  Martin, Natasha K ^a,b   Gaffney, Eamonn A ^a   Gatenby, Robert A ^c   Gillies, Robert J ^c   Robey, Ian F ^d   Maini, Philip K ^a,e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Acidity; Bicarbonate; Buffering; Cancer

Indexed keywords

APPROXIMATE ANALYTICAL SOLUTIONS; BICARBONATE; BUFFERING; CANCER; COMBINATION THERAPY; EXTRACELLULAR PH; KEY PARAMETERS; NUMERICAL SIMULATION; POTENTIAL BENEFITS; TUMOURS;

BLOOD; COMPUTER SIMULATION; DISEASES; ENZYME ACTIVITY; MATHEMATICAL MODELS; ORDINARY DIFFERENTIAL EQUATIONS; PATHOLOGY; SENSITIVITY ANALYSIS; TUMORS;

PHYSIOLOGICAL MODELS;

BICARBONATE; BUFFER; CARBON DIOXIDE;

ACIDITY; BLOOD; COMPUTER SIMULATION; EXPERIMENTAL STUDY; LABORATORY METHOD; METABOLISM; MODEL VALIDATION; NUMERICAL MODEL; PH; PHYSIOLOGICAL RESPONSE; RESPIRATION; SURVIVAL; TUMOR;

ARTICLE; BLOOD PH; CHEMICAL REACTION; COMPARTMENT MODEL; CONTROLLED STUDY; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MATHEMATICAL COMPUTING; METABOLIC ACIDOSIS; METABOLIC ALKALOSIS; PH; REGULATORY MECHANISM; RESPIRATORY ACIDOSIS; RESPIRATORY ALKALOSIS; SENSITIVITY ANALYSIS; SPECIES COMPARISON; TUMOR PH;

ACID-BASE EQUILIBRIUM; ACIDOSIS; ACIDOSIS, RESPIRATORY; ALGORITHMS; ALKALOSIS; ALKALOSIS, RESPIRATORY; ANIMALS; BICARBONATES; BLOOD; BUFFERS; CARBON DIOXIDE; COMPUTER SIMULATION; EXTRACELLULAR SPACE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MICE; MODELS, BIOLOGICAL; NEOPLASMS;

MUS;

EID: 84857109910     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mbs.2010.12.002     Document Type: Article

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