Preferential binding of insecticide phorate with sub-domain IIA of human serum albumin induces protein damage and its toxicological significance

Food and Chemical Toxicology

Volumn 49, Issue 8, 2011, Pages 1787-1795

  Saquib, Quaiser ^a,b   Al Khedhairy, Abdulaziz A ^a,b   Siddiqui, Maqsood A ^a   Roy, Atanu Singha ^d   Dasgupta, Swagata ^d   Musarrat, Javed ^a,b,c  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c ALIGARH MUSLIM UNIVERSITY   (India)

^d INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Cytotoxicity; Fluorescence spectroscopy; Human serum albumin; Insecticide; Molecular modeling; Phorate

Indexed keywords

ALKYL GROUP; AMINE; CARBONYL DERIVATIVE; HUMAN SERUM ALBUMIN; PHORATE; REACTIVE OXYGEN METABOLITE;

ALPHA HELIX; AMNION CELL; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL ULTRASTRUCTURE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTROPHILICITY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; TOXICITY TESTING;

CELL DEATH; CELL LINE; CIRCULAR DICHROISM; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; OXIDATIVE STRESS; PHORATE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; REACTIVE OXYGEN SPECIES; SERUM ALBUMIN; SPECTROMETRY, FLUORESCENCE; TRYPTOPHAN;

EID: 79958695941     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.04.028     Document Type: Article

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