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Volumn 28, Issue 11, 2007, Pages 573-579

Selective and mixed endothelin receptor antagonism in cardiovascular disease

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN; CLAZOSENTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; NITRIC OXIDE; SITAXSENTAN;

EID: 35648934472     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2007.10.002     Document Type: Review
Times cited : (67)

References (72)
  • 2
    • 0027161460 scopus 로고
    • The endothelin family of peptides: local hormones with diverse roles in health and disease?
    • Haynes W.G., and Webb D.J. The endothelin family of peptides: local hormones with diverse roles in health and disease?. Clin. Sci. 84 (1993) 485-500
    • (1993) Clin. Sci. , vol.84 , pp. 485-500
    • Haynes, W.G.1    Webb, D.J.2
  • 3
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • Yanagisawa M., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332 (1988) 411-415
    • (1988) Nature , vol.332 , pp. 411-415
    • Yanagisawa, M.1
  • 4
    • 0034993096 scopus 로고    scopus 로고
    • Role of endothelin-1 in hypertension and vascular disease
    • Schiffrin E.L. Role of endothelin-1 in hypertension and vascular disease. Am. J. Hypertens. 14 (2001) 83S-89S
    • (2001) Am. J. Hypertens. , vol.14
    • Schiffrin, E.L.1
  • 5
    • 0027733802 scopus 로고
    • Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in situ hybridization, and subtype-selective ligands BQ123 and BQ3020: evidence for expression of ETB receptors in human vascular smooth muscle
    • Davenport A.P., et al. Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in situ hybridization, and subtype-selective ligands BQ123 and BQ3020: evidence for expression of ETB receptors in human vascular smooth muscle. J. Cardiovasc. Pharmacol. 22 (1993) S22-S25
    • (1993) J. Cardiovasc. Pharmacol. , vol.22
    • Davenport, A.P.1
  • 6
    • 0004559340 scopus 로고
    • Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
    • DeNucci G., et al. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc. Natl. Acad. Sci. U. S. A 85 (1988) 9797-9800
    • (1988) Proc. Natl. Acad. Sci. U. S. A , vol.85 , pp. 9797-9800
    • DeNucci, G.1
  • 7
    • 33645472590 scopus 로고    scopus 로고
    • The endothelin system and its antagonism in chronic kidney disease
    • Dhaun N., et al. The endothelin system and its antagonism in chronic kidney disease. J. Am. Soc. Nephrol. 17 (2006) 943-955
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 943-955
    • Dhaun, N.1
  • 8
    • 0026597525 scopus 로고
    • Regional haemodynamic effects and clearance of endothelin-1 in humans: renal and peripheral tissues may contribute to overall disposal of the peptide
    • Gasic S., et al. Regional haemodynamic effects and clearance of endothelin-1 in humans: renal and peripheral tissues may contribute to overall disposal of the peptide. J. Cardiovasc. Pharmacol. 19 (1992) 176-180
    • (1992) J. Cardiovasc. Pharmacol. , vol.19 , pp. 176-180
    • Gasic, S.1
  • 9
    • 0029741347 scopus 로고    scopus 로고
    • Human pulmonary circulation is an important site for both clearance and production of endothelin-1
    • Dupuis J., et al. Human pulmonary circulation is an important site for both clearance and production of endothelin-1. Circulation 94 (1996) 1278-1284
    • (1996) Circulation , vol.94 , pp. 1278-1284
    • Dupuis, J.1
  • 10
    • 20044366257 scopus 로고    scopus 로고
    • Endothelin antagonism in pulmonary hypertension, heart failure, and beyond
    • Attina T., et al. Endothelin antagonism in pulmonary hypertension, heart failure, and beyond. Heart 91 (2005) 825-831
    • (2005) Heart , vol.91 , pp. 825-831
    • Attina, T.1
  • 11
    • 35648963436 scopus 로고    scopus 로고
    • Available at
    • Available at. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2263
  • 12
    • 0033613134 scopus 로고    scopus 로고
    • An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
    • Lahav R., et al. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc. Natl. Acad. Sci. U. S. A 96 (1999) 11496-11500
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 11496-11500
    • Lahav, R.1
  • 13
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo G.E., et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann. Intern. Med. 115 (1991) 343-349
    • (1991) Ann. Intern. Med. , vol.115 , pp. 343-349
    • D'Alonzo, G.E.1
  • 14
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • Rubin L.J., et al. Bosentan therapy for pulmonary arterial hypertension. N. Engl. J. Med. 346 (2002) 896-903
    • (2002) N. Engl. J. Med. , vol.346 , pp. 896-903
    • Rubin, L.J.1
  • 15
    • 33646526270 scopus 로고    scopus 로고
    • Endothelin receptor antagonists
    • Motte S., et al. Endothelin receptor antagonists. Pharmacol. Ther. 110 (2006) 386-414
    • (2006) Pharmacol. Ther. , vol.110 , pp. 386-414
    • Motte, S.1
  • 16
    • 0035030413 scopus 로고    scopus 로고
    • Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction
    • Ivy D., et al. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am. J. Physiol. 280 (2001) L1040-L1048
    • (2001) Am. J. Physiol. , vol.280
    • Ivy, D.1
  • 17
    • 0033715820 scopus 로고    scopus 로고
    • Prolonged endothelin B receptor blockade causes pulmonary hypertension in the ovine fetus
    • Ivy D.D., et al. Prolonged endothelin B receptor blockade causes pulmonary hypertension in the ovine fetus. Am. J. Physiol. 279 (2000) L758-L765
    • (2000) Am. J. Physiol. , vol.279
    • Ivy, D.D.1
  • 18
    • 0028800341 scopus 로고
    • Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs
    • Sato K., et al. Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs. Am. J. Physiol. 269 (1995) L668-L672
    • (1995) Am. J. Physiol. , vol.269
    • Sato, K.1
  • 19
    • 0028921779 scopus 로고
    • Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats
    • Eddahibi S., et al. Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats. Am. J. Physiol. 268 (1995) H828-H835
    • (1995) Am. J. Physiol. , vol.268
    • Eddahibi, S.1
  • 20
    • 0033758617 scopus 로고    scopus 로고
    • Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist
    • Tilton R.G., et al. Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist. Pulm. Pharmacol. Ther. 13 (2000) 87-97
    • (2000) Pulm. Pharmacol. Ther. , vol.13 , pp. 87-97
    • Tilton, R.G.1
  • 21
    • 0030814723 scopus 로고    scopus 로고
    • The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats
    • Chen S.J., et al. The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats. J. Cardiovasc. Pharmacol. 29 (1997) 713-725
    • (1997) J. Cardiovasc. Pharmacol. , vol.29 , pp. 713-725
    • Chen, S.J.1
  • 22
    • 10744230817 scopus 로고    scopus 로고
    • Sitaxsentan therapy for pulmonary arterial hypertension
    • Barst R.J., et al. Sitaxsentan therapy for pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 169 (2004) 441-447
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 441-447
    • Barst, R.J.1
  • 23
    • 33646255654 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
    • Barst R.J., et al. Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J. Am. Coll. Cardiol. 47 (2006) 2049-2056
    • (2006) J. Am. Coll. Cardiol. , vol.47 , pp. 2049-2056
    • Barst, R.J.1
  • 24
    • 0032546259 scopus 로고    scopus 로고
    • The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension
    • Krum H., et al. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. N. Engl. J. Med. 338 (1998) 784-790
    • (1998) N. Engl. J. Med. , vol.338 , pp. 784-790
    • Krum, H.1
  • 25
    • 0033898202 scopus 로고    scopus 로고
    • Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice
    • Hocher B., et al. Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice. Am. J. Respir. Cell Mol. Biol. 23 (2000) 19-26
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.23 , pp. 19-26
    • Hocher, B.1
  • 26
    • 0036468709 scopus 로고    scopus 로고
    • ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells
    • Davie N., et al. ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells. Am. J. Respir. Crit. Care Med. 165 (2002) 398-405
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , pp. 398-405
    • Davie, N.1
  • 27
    • 16644395875 scopus 로고    scopus 로고
    • Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats
    • Nishida M., et al. Role of endothelin ETB receptor in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats. Eur. J. Pharmacol. 496 (2004) 159-165
    • (2004) Eur. J. Pharmacol. , vol.496 , pp. 159-165
    • Nishida, M.1
  • 28
    • 3242767660 scopus 로고    scopus 로고
    • Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension
    • Nishida M., et al. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. J. Cardiovasc. Pharmacol. 44 (2004) 187-191
    • (2004) J. Cardiovasc. Pharmacol. , vol.44 , pp. 187-191
    • Nishida, M.1
  • 29
    • 0029918005 scopus 로고    scopus 로고
    • Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart
    • Sakai S., et al. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure. Marked increase in endothelin-1 production in the failing heart. Circulation 93 (1996) 1214-1222
    • (1996) Circulation , vol.93 , pp. 1214-1222
    • Sakai, S.1
  • 30
    • 0032906621 scopus 로고    scopus 로고
    • Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart
    • Kobayashi T., et al. Expression of endothelin-1, ETA and ETB receptors, and ECE and distribution of endothelin-1 in failing rat heart. Am. J. Physiol. 276 (1999) H1197-H1206
    • (1999) Am. J. Physiol. , vol.276
    • Kobayashi, T.1
  • 31
    • 0033551089 scopus 로고    scopus 로고
    • Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium
    • Pieske B., et al. Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium. Circulation 99 (1999) 1802-1809
    • (1999) Circulation , vol.99 , pp. 1802-1809
    • Pieske, B.1
  • 32
    • 0034255016 scopus 로고    scopus 로고
    • Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure
    • Mulder P., et al. Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure. Circulation 102 (2000) 491-493
    • (2000) Circulation , vol.102 , pp. 491-493
    • Mulder, P.1
  • 33
    • 0032167644 scopus 로고    scopus 로고
    • Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure
    • Ohnishi M., et al. Comparison of the acute effects of a selective endothelin ETA and a mixed ETA/ETB receptor antagonist in heart failure. Cardiovasc. Res. 39 (1998) 617-624
    • (1998) Cardiovasc. Res. , vol.39 , pp. 617-624
    • Ohnishi, M.1
  • 34
    • 11844304145 scopus 로고    scopus 로고
    • Comparison of selective ET(A) and ET(B) receptor antagonists in patients with chronic heart failure
    • Cowburn P.J., et al. Comparison of selective ET(A) and ET(B) receptor antagonists in patients with chronic heart failure. Eur. J. Heart Fail. 7 (2005) 37-42
    • (2005) Eur. J. Heart Fail. , vol.7 , pp. 37-42
    • Cowburn, P.J.1
  • 35
    • 33744922911 scopus 로고    scopus 로고
    • Battistini, B. et al. (2006) Profile of Past and Current Clinical Triaqls Involving Endothelin Receptor Antagonists: The Novel "-Sentan" Class of Drug. Soc Exp Biol Med
  • 36
    • 3242810591 scopus 로고    scopus 로고
    • Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the Endothelin A Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial
    • Anand I., et al. Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the Endothelin A Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. Lancet 364 (2004) 327-354
    • (2004) Lancet , vol.364 , pp. 327-354
    • Anand, I.1
  • 37
    • 0037137297 scopus 로고    scopus 로고
    • Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT)
    • Luscher T.F., et al. Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT). Circulation 106 (2002) 2666-2672
    • (2002) Circulation , vol.106 , pp. 2666-2672
    • Luscher, T.F.1
  • 38
    • 0033537665 scopus 로고    scopus 로고
    • Endothelin-1 and its mRNA in the wall layers of human arteries ex vivo
    • Rossi G.P., et al. Endothelin-1 and its mRNA in the wall layers of human arteries ex vivo. Circulation 99 (1999) 1147-1155
    • (1999) Circulation , vol.99 , pp. 1147-1155
    • Rossi, G.P.1
  • 39
    • 0032999576 scopus 로고    scopus 로고
    • Role of endothelin in the increased vascular tone of patients with essential hypertension
    • Cardillo C., et al. Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension 33 (1999) 753-758
    • (1999) Hypertension , vol.33 , pp. 753-758
    • Cardillo, C.1
  • 40
    • 0036201208 scopus 로고    scopus 로고
    • Effect of endothelin blockade on basal and stimulated forearm blood flow in patients with essential hypertension
    • Martin P., et al. Effect of endothelin blockade on basal and stimulated forearm blood flow in patients with essential hypertension. Hypertension 39 (2002) 821-824
    • (2002) Hypertension , vol.39 , pp. 821-824
    • Martin, P.1
  • 41
    • 1542514709 scopus 로고    scopus 로고
    • Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade
    • Goddard J., et al. Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade. Circulation 109 (2004) 1186-1193
    • (2004) Circulation , vol.109 , pp. 1186-1193
    • Goddard, J.1
  • 42
    • 0036634351 scopus 로고    scopus 로고
    • Darusentan: an effective endothelinA receptor antagonist for treatment of hypertension
    • Nakov R., et al. Darusentan: an effective endothelinA receptor antagonist for treatment of hypertension. Am. J. Hypertens. 15 (2002) 583-589
    • (2002) Am. J. Hypertens. , vol.15 , pp. 583-589
    • Nakov, R.1
  • 43
    • 0025782886 scopus 로고
    • Immunoreactive endothelin in human kidney
    • Morita S., et al. Immunoreactive endothelin in human kidney. Ann. Clin. Biochem. 28 (1991) 267-271
    • (1991) Ann. Clin. Biochem. , vol.28 , pp. 267-271
    • Morita, S.1
  • 44
    • 0030044458 scopus 로고    scopus 로고
    • Localization of endothelin peptides in human kidney
    • Karet F.E., and Davenport A.P. Localization of endothelin peptides in human kidney. Kidney Int. 49 (1996) 382-387
    • (1996) Kidney Int. , vol.49 , pp. 382-387
    • Karet, F.E.1    Davenport, A.P.2
  • 45
    • 11144314951 scopus 로고    scopus 로고
    • Comparison of endothelin-A and endothelin-B receptor distribution visualized by radioligand binding versus immunocytochemical localization using subtype selective antisera
    • Kuc R., and Davenport A.P. Comparison of endothelin-A and endothelin-B receptor distribution visualized by radioligand binding versus immunocytochemical localization using subtype selective antisera. J. Cardiovasc. Pharmacol. 44 (2004) S224-S226
    • (2004) J. Cardiovasc. Pharmacol. , vol.44
    • Kuc, R.1    Davenport, A.P.2
  • 46
    • 0029974496 scopus 로고    scopus 로고
    • Influence of specific and non-specific endothelin receptor antagonists on renal morphology in rats with surgical renal ablation
    • Nabokov A., et al. Influence of specific and non-specific endothelin receptor antagonists on renal morphology in rats with surgical renal ablation. Nephrol. Dial. Transplant. 11 (1996) 514-520
    • (1996) Nephrol. Dial. Transplant. , vol.11 , pp. 514-520
    • Nabokov, A.1
  • 47
    • 0032796240 scopus 로고    scopus 로고
    • Protective effects of endothelin antagonists in chronic renal failure
    • Wolf S.C., et al. Protective effects of endothelin antagonists in chronic renal failure. Nephrol. Dial. Transplant. 14 (1999) 29-30
    • (1999) Nephrol. Dial. Transplant. , vol.14 , pp. 29-30
    • Wolf, S.C.1
  • 48
    • 0032857428 scopus 로고    scopus 로고
    • Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats
    • Shimizu T., et al. Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats. Eur. J. Pharmacol. 381 (1999) 39-49
    • (1999) Eur. J. Pharmacol. , vol.381 , pp. 39-49
    • Shimizu, T.1
  • 49
    • 0024603433 scopus 로고
    • Effect of endothelin-1 on regional vascular resistance in the pig
    • Pernow J., et al. Effect of endothelin-1 on regional vascular resistance in the pig. J. Cardiovasc. Pharmacol. 13 (1989) S205-S206
    • (1989) J. Cardiovasc. Pharmacol. , vol.13
    • Pernow, J.1
  • 50
    • 3843121257 scopus 로고    scopus 로고
    • Effect of endothelin-1 on regional kidney blood flow and renal arteriole calibre in rabbits
    • Denton K.M., et al. Effect of endothelin-1 on regional kidney blood flow and renal arteriole calibre in rabbits. Clin. Exp. Pharmacol. Physiol. 31 (2004) 494-501
    • (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 494-501
    • Denton, K.M.1
  • 51
    • 0028881150 scopus 로고
    • Differential effect of endothelin-1 on renal regional blood flow: role of nitric oxide
    • Rubinstein I., et al. Differential effect of endothelin-1 on renal regional blood flow: role of nitric oxide. J. Cardiovasc. Pharmacol. 26 (1995) S208-S210
    • (1995) J. Cardiovasc. Pharmacol. , vol.26
    • Rubinstein, I.1
  • 52
    • 0034806025 scopus 로고    scopus 로고
    • Effects of ET(A) - and ET(B)-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits
    • Evans R.G., et al. Effects of ET(A) - and ET(B)-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits. J. Hypertens. 19 (2001) 1789-1799
    • (2001) J. Hypertens. , vol.19 , pp. 1789-1799
    • Evans, R.G.1
  • 53
    • 0037716348 scopus 로고    scopus 로고
    • Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat
    • Ding S.S., et al. Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat. J. Cardiovasc. Pharmacol. 42 (2003) 48-54
    • (2003) J. Cardiovasc. Pharmacol. , vol.42 , pp. 48-54
    • Ding, S.S.1
  • 54
    • 0029015053 scopus 로고
    • Endothelin A receptor mediates functional but not structural damage in chronic cyclosporine nephrotoxicity
    • Hunley T.E., et al. Endothelin A receptor mediates functional but not structural damage in chronic cyclosporine nephrotoxicity. J. Am. Soc. Nephrol. 5 (1995) 1718-1723
    • (1995) J. Am. Soc. Nephrol. , vol.5 , pp. 1718-1723
    • Hunley, T.E.1
  • 55
    • 35648950942 scopus 로고    scopus 로고
    • Available at
    • Available at. http://www.clinicaltrials.gov/ct/show/NCT00120328
  • 56
    • 28444465856 scopus 로고    scopus 로고
    • ET(A) and ET(B) receptors differentially modulate afferent and efferent arteriolar responses to endothelin
    • Inscho E.W., et al. ET(A) and ET(B) receptors differentially modulate afferent and efferent arteriolar responses to endothelin. Br. J. Pharmacol. 146 (2005) 1019-1026
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 1019-1026
    • Inscho, E.W.1
  • 57
    • 16644384951 scopus 로고    scopus 로고
    • Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism
    • Goddard J., et al. Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism. J. Am. Soc. Nephrol. 15 (2004) 2601-2610
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 2601-2610
    • Goddard, J.1
  • 58
    • 0035928758 scopus 로고    scopus 로고
    • Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis
    • Ihling C., et al. Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis. Circulation 104 (2001) 864-869
    • (2001) Circulation , vol.104 , pp. 864-869
    • Ihling, C.1
  • 59
    • 0028902844 scopus 로고
    • Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol
    • Kowala M.C., et al. Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol. Am. J. Pathol. 146 (1995) 819-826
    • (1995) Am. J. Pathol. , vol.146 , pp. 819-826
    • Kowala, M.C.1
  • 60
    • 0032564279 scopus 로고    scopus 로고
    • Endothelin ET(A) receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
    • Barton M., et al. Endothelin ET(A) receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc. Natl. Acad. Sci. U. S. A 95 (1998) 14367-14372
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , pp. 14367-14372
    • Barton, M.1
  • 61
    • 0033528717 scopus 로고    scopus 로고
    • Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolaemia
    • Best P.J.M., et al. Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolaemia. Circulation 99 (1999) 1747-1752
    • (1999) Circulation , vol.99 , pp. 1747-1752
    • Best, P.J.M.1
  • 62
    • 0033772331 scopus 로고    scopus 로고
    • Blockade of endothelin receptors markedly reduces atherosclerosis in LDL receptor deficient mice: role of endothelin in macrophage foam cell formation
    • Babaei S., et al. Blockade of endothelin receptors markedly reduces atherosclerosis in LDL receptor deficient mice: role of endothelin in macrophage foam cell formation. Cardiovasc. Res. 48 (2000) 158-167
    • (2000) Cardiovasc. Res. , vol.48 , pp. 158-167
    • Babaei, S.1
  • 63
    • 0036159696 scopus 로고    scopus 로고
    • Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice
    • d'Uscio L.V., et al. Chronic ET(A) receptor blockade prevents endothelial dysfunction of small arteries in apolipoprotein E-deficient mice. Cardiovasc. Res. 53 (2002) 487-495
    • (2002) Cardiovasc. Res. , vol.53 , pp. 487-495
    • d'Uscio, L.V.1
  • 64
    • 0035941416 scopus 로고    scopus 로고
    • Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade
    • Halcox J.P., et al. Coronary vasodilation and improvement in endothelial dysfunction with endothelin ET(A) receptor blockade. Circ. Res. 89 (2001) 969-976
    • (2001) Circ. Res. , vol.89 , pp. 969-976
    • Halcox, J.P.1
  • 65
    • 34247880262 scopus 로고    scopus 로고
    • Endogenous endothelin in human coronary vascular function. Differential contribution of endothelin receptor types A and B
    • Halcox J.P., et al. Endogenous endothelin in human coronary vascular function. Differential contribution of endothelin receptor types A and B. Hypertension 49 (2007) 1-8
    • (2007) Hypertension , vol.49 , pp. 1-8
    • Halcox, J.P.1
  • 66
    • 33644820886 scopus 로고    scopus 로고
    • Endothelial influences on cerebrovascular tone
    • Andresen J., et al. Endothelial influences on cerebrovascular tone. J. Appl. Physiol. 100 (2006) 318-327
    • (2006) J. Appl. Physiol. , vol.100 , pp. 318-327
    • Andresen, J.1
  • 67
    • 0034831353 scopus 로고    scopus 로고
    • Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats
    • Matsuo Y., et al. Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats. Stroke 32 (2001) 2143-2148
    • (2001) Stroke , vol.32 , pp. 2143-2148
    • Matsuo, Y.1
  • 68
    • 0035074344 scopus 로고    scopus 로고
    • Acute alterations of endothelin-1 and iNOS expression and control of the brain microcirculation after head trauma
    • Petrov T., and Rafols J.A. Acute alterations of endothelin-1 and iNOS expression and control of the brain microcirculation after head trauma. Neurol. Res. 23 (2001) 139-143
    • (2001) Neurol. Res. , vol.23 , pp. 139-143
    • Petrov, T.1    Rafols, J.A.2
  • 69
    • 0036957842 scopus 로고    scopus 로고
    • Endothelin receptor antagonists and cerebral vasospasm: an update
    • Chow M., et al. Endothelin receptor antagonists and cerebral vasospasm: an update. Neurosurgery 51 (2002) 1333-1341
    • (2002) Neurosurgery , vol.51 , pp. 1333-1341
    • Chow, M.1
  • 70
    • 34248524672 scopus 로고    scopus 로고
    • Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution
    • Macdonald R.L., et al. Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution. Nat. Clin. Pract. Neurol. 3 (2007) 256-263
    • (2007) Nat. Clin. Pract. Neurol. , vol.3 , pp. 256-263
    • Macdonald, R.L.1
  • 71
    • 0032989852 scopus 로고    scopus 로고
    • Nitric oxide, endothelin and nephron transport: potential interactions
    • Plato C.F., and Garvin J.L. Nitric oxide, endothelin and nephron transport: potential interactions. Clin. Exp. Pharmacol. Physiol. 26 (1999) 262-268
    • (1999) Clin. Exp. Pharmacol. Physiol. , vol.26 , pp. 262-268
    • Plato, C.F.1    Garvin, J.L.2
  • 72
    • 0033914834 scopus 로고    scopus 로고
    • Selective ET(A) receptor antagonism with ABT-627 attenuates all renal effects of endothelin in humans
    • Honing M.L., et al. Selective ET(A) receptor antagonism with ABT-627 attenuates all renal effects of endothelin in humans. J. Am. Soc. Nephrol. 11 (2000) 1498-1504
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 1498-1504
    • Honing, M.L.1


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