Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1

Infection and Immunity

Volumn 79, Issue 5, 2011, Pages 1873-1881

  Gutierrez, Fredy R S ^a,f   Mariano, Flávia S ^a   Oliveira, Carlo J F ^a   Pavanelli, Wander R ^a   Guedes, Paulo M M ^a   Silva, Grace K ^a   Campanelli, Ana P ^a   Milanezi, Cristiane M ^a   Azuma, Miyuki ^b   Honjo, Tasuku ^c   Teixeira, Mauro M ^d   Aliberti, Julio C S ^e   Silva, João S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^f CENTRO DE INVESTIGACIONES   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CHAGAS DISEASE; CLONAL ANERGY; CONTROLLED STUDY; CYTOMETRY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRYPANOSOMA CRUZI; UPREGULATION;

ANIMALS; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; CELL SEPARATION; CHAGAS CARDIOMYOPATHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRYPANOSOMA CRUZI;

EID: 79955625559     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01047-10     Document Type: Article

References (39)

1. Agata, Y., et al. 1996. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8:765-772.
2. Alvarez, I. B., et al. 2010. Role played by the programmed death-1-pro-grammed death ligand pathway during innate immunity against Mycobacterium tuberculosis. J. Infect. Dis. 202:524-532.
3. Ansari, M. J., et al. 2003. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 198:63-69.
4. Babu, S., C. P. Blauvelt, V. Kumaraswami, and T. B. Nutman. 2006. Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. J. Immunol. 176:3248-3256.
5. Barber, D. L., et al. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682-687.
6. Blank, C, and A. Mackensen. 2007. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol. Immunother. 56:739-745.
7. Blazar, B. R., et al. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J. Immunol. 171:1272-1277.
8. Carreno, B. M., and M. Collins. 2002. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 20:29-53.
9. Dong, H., G. Zhu, K. Tamada, and L. Chen. 1999. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5:1365-1369.
10. Engman, D. M., E. A. Dragon, and J. E. Donelson. 1990. Human humoral immunity to hsp70 during Trypanosoma cruzi infection. J. Immunol. 144: 3987-3991.
11. 2+-binding protein in try-panosomes. J. Biol. Chem. 264:18627-18631.
12. Golgher, D., and R. T. Gazzinelli. 2004. Innate and acquired immunity in the pathogenesis of Chagas disease. Autoimmunity 37:399-409.
13. Gomes, J. A., et al. 2003. Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infect. Immun. 71:1185-1193.
14. Iwai, Y., et al. 2002. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. U. S. A. 99:12293-12297.
15. Iwai, Y., S. Terawaki, M. Ikegawa, T. Okazaki, and T. Honjo. 2003. PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 198:39-50.
16. + T cells during acute HCV infection, irrespective of clinical outcome. J. Virol. 82:3154-3160.
17. Kotner, J., and R. Tarleton. 2007. Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in mice. Infect. Immun. 75:861-869.
18. Latchman, Y., et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2:261-268.
19. Levin, M. J., et al. 1989. Identification of major Trypanosoma cruzi antigenic determinants in chronic Chagas' heart disease. Am. J. Trop. Med. Hyg. 41:530-538.
20. Mariano, F. S., et al. 2008. The involvement of CD4(+) CD25(+) T cells in the acute phase of Trypanosoma cruzi infection. Microbes Infect. 10:825-833.
21. Marin-Neto, J. A., E. Cunha-Neto, B. C. Maciel, and M. V. Simoes. 2007. Pathogenesis of chronic Chagas heart disease. Circulation 115:1109-1123.
22. Martins, G. A., M. A. Cardoso, J. C. Aliberti, and J. S. Silva. 1998. Nitric oxide-induced apoptotic cell death in the acute phase of Trypanosoma cruzi infection in mice. Immunol. Lett. 63:113-120.
23. Martins, G. A., C. E. Tadokoro, R. B. Silva, J. S. Silva, and L. V. Rizzo. 2004. CTLA-4 blockage increases resistance to infection with the intracellular protozoan Trypanosoma cruzi. J. Immunol. 172:4893-4901.
24. Nishimura, H., and T. Honjo. 2001. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 22:265-268.
25. Nishimura, H., et al. 2001. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319-322.
26. Okazaki, T., et al. 2003. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat. Med. 9:1477-1483.
27. Overbergh, L., et al. 2003. The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J. Biomol. Tech. 14:33-43.
28. Poncini, C. V., C. D. Alba Soto, E. Batalla, M. E. Solana, and S. M. Gonzalez Cappa. 2008. Trypanosoma cruzi induces regulatory dendritic cells in vitro. Infect. Immun. 76:2633-2641.
29. Roffe, E., et al. 2007. Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice. Braz. J. Med. Biol. Res. 40:391-399.
30. Rossi, M. A. 1991. Patterns of myocardial fibrosis in idiopathic cardiomyopathies and chronic Chagasic cardiopathy. Can. J. Cardiol. 7:287-294.
31. Salama, A. D., et al. 2003. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J. Exp. Med. 198:71-78.
32. Savino, W., et al. 2007. Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi. Cytokine Growth Factor Rev. 18:107-124.
33. Soares, M. B., L. Pontes-De-Carvalho, and R. Ribeiro-Dos-Santos. 2001. The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet. An. Acad. Bras. Cienc. 73:547-559.
34. Souza, P. E., et al. 2007. Trypanosoma cruzi infection induces differential modulation of costimulatory molecules and cytokines by monocytes and T cells from patients with indeterminate and cardiac Chagas' disease. Infect. Immun. 75:1886-1894.
35. Teixeira, M. M., R. T. Gazzinelli, and J. S. Silva. 2002. Chemokines, inflammation and Trypanosoma cruzi infection. Trends Parasitol. 18:262-265.
36. Terrazas, L. I., D. Montero, C. A. Terrazas, J. L. Reyes, and M. Rodriguez-Sosa. 2005. Role of the programmed Death-1 pathway in the suppressive activity of alternatively activated macrophages in experimental cysticercosis. Int. J. Parasitol. 35:1349-1358.
37. Van Voorhis, W. C, and H. Eisen. 1989. Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J. Exp. Med. 169:641-652.
38. + CD25 high regulatory T lymphocytes. Scand. J. Immunol. 62:297-308.
39. Wan, B., et al. 2006. Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J. Immunol. 177: 8844-8850.