The role and regulation of microRNAs in asthma

Current Opinion in Allergy and Clinical Immunology

Volumn 12, Issue 1, 2012, Pages 49-52

  Ariel, Danit ^a   Upadhyay, Daya ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; Inflammation; MicroRNAs

Indexed keywords

MESSENGER RNA; MICRORNA;

ACUTE DISEASE; AIRWAY OBSTRUCTION; AIRWAY REMODELING; ASTHMA; BRONCHUS HYPERREACTIVITY; CHRONIC DISEASE; GENE EXPRESSION REGULATION; HUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RNA ANALYSIS; SIGNAL TRANSDUCTION;

ASTHMA; BRONCHIAL HYPERREACTIVITY; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MICRORNAS;

EID: 84857062676     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e32834ecb7f     Document Type: Review

References (52)

1. Masoli M, Fabian D, Holt S, et al., Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59:469-478. (Pubitemid 38580764)
2. Akinbami LJ, Moorman JE, Liu X. Asthma prevalence, health care use, and mortality: United States, 2005-2009. Natl Health Stat Report 2011; 12:1-14.
3. Busse WW, Lemanske RF Jr. Asthma. N Engl J Med 2001; 344:350-362. (Pubitemid 32107645)
4. Izuhara K, Saito H. Microarray-based identification of novel biomarkers in asthma. Allergol Int 2006; 55:361-367. (Pubitemid 46065424)
5. Williams AE, Larner-Svensson H, Perry MM, et al. MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One 2009; 4:e5889.
6. Horváth I, Hunt J, Barnes PJ, et al., ATS/ERS Task Force on Exhaled Breath Condensate. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005; 26:523-548. (Pubitemid 41264218)
7. Tomankova T, Petrek M, Kriegova E. Involvement of microRNAs in physiological and pathological processes in the lung. Respir Res 2010; 11:159. An interesting insight into the role of miRs in human pathophysiology.
8. Oglesby IK, McElvaney NG, Greene CM. MicroRNAs in inflammatory lung disease: master regulators or target practice? Respir Res 2010; 11:148.
9. Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007; 104:15805-15810. (Pubitemid 350035380)
10. Mertens-Talcott SU, Chintharlapalli S, Li X, et al. The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res 2007; 67:11001-11011. (Pubitemid 350145930)
11. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75:843-854. (Pubitemid 24014542)
12. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-811. (Pubitemid 28099681)
13. Lagos-Quintana M, Rauhut R, Lendeckel W, et al. Identification of novel genes coding for small expressed RNAs. Science 2001; 294:853-858. (Pubitemid 33032103)
14. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
15. Wu X, Piper-Hunter MG, Crawford M, et al. MicroRNAs in the pathogenesis of lung cancer. J Thorac Oncol 2009; 4:1028-1034.
16. Zhang B, Pan X, Cobb GP, Anderson TA. MicroRNAs as oncogenes and tumor suppressors. Dev Biol 2007; 302:1-12. (Pubitemid 46096921)
17. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science 2007; 318:1931-1934.
18. Grosshans H, Filipowicz W. Molecular biology: the expanding world of small RNAs. Nature 2008; 451:414-416. (Pubitemid 351158877)
19. John B, Enright AJ, Aravin A, et al. Human microRNA targets. PLoS Biol 2004; 2:e363.
20. Takacs CM, Giraldez AJ. MicroRNAs as genetic sculptors: fishing for clues. Semin Cell Dev Biol 2010; 21:760-767.
21. Wiesen JL, Tomasi TB. Dicer is regulated by cellular stresses and interferons. Mol Immunol 2009; 46:1222-1228.
22. Suzuki HI, Yamagata K, Sugimoto K, et al. Modulation of microRNA processing by p53. Nature 2009; 460:529-533.
23. Saito Y, Friedman JM, Chihara Y, et al. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun 2009; 379:726-731.
24. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5:522-531. (Pubitemid 38868508)
25. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9:102-114.
26. Garbacki N, Di Valentin E, Huynh-Thu VA, et al. MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets. PLoS One 2011; 6:e16509.
27. Mattes J, Collison A, Foster PS. Emerging role of microRNAs in disease pathogenesis and strategies for therapeutic modulation. Curr Opin Mol Ther 2008; 10:150-157. (Pubitemid 351498877)
28. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005; 438:685-689.
29. Griffiths-Jones S, Grocock RJ, van Dongen S, et al. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2006; 34:D140-D144.
30. Berezikov E, Guryev V, van de Belt J, et al. Phylogenetic shadowing and computational identification of human microRNA genes. Cell 2005; 120:21-24. (Pubitemid 40094599)
31. Grimson A, Farh KK, Johnston WK, et al. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 2007; 27:91-105. (Pubitemid 46991392)
32. Friedman RC, Farh KK, Burge CB, et al. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19:92-105.
33. Sheedy FJ, Palsson-McDermott E, Hennessy EJ, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol 2009; 11:141-147.
34. O'Connell RM, Taganov KD, Boldin MP, et al. MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A 2007; 104:1604-1609. (Pubitemid 46214637)
35. Lindsay MA. MicroRNAs and the immune response. Trends Immunol 2008; 29:343-351.
36. Mattes J, Yang M, Foster PS. Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function? Am J Respir Cell Mol Biol 2007; 36:8-12. (Pubitemid 46067702)
37. Sayed D, Abdellatif M. MicroRNAs in development and disease. Physiol Rev 2011; 91:827-887. An interesting insight into the role of miRs in various diseases in human.
38. Mattes J, Collison A, Plank M, et al. Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci U S A 2009; 106:18704-18709.
39. Asirvatham AJ, Gregorie CJ, Hu Z, et al. MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol 2008; 45:1995-2006. (Pubitemid 351226272)
40. Holt PG, Macaubas C, Stumbles PA, et al. The role of allergy in the development of asthma. Nature 1999; 402 (6760 Suppl):B12-B17.
41. Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282:2258-2261. (Pubitemid 29004074)
42. Grunig G, Warnock M, Wakil AE, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:2261-2263. (Pubitemid 29004075)
43. Rodriguez A, Vigorito E, Clare S, et al. Requirement of bic/microRNA-155 for normal immune function. Science 2007; 316:608-611. (Pubitemid 46683148)
44. Costinean S, Zanesi N, Pekarsky Y, et al. Pre-B cell proliferation and lymphoblastic leukemia/high grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A 2006; 103:7024-7029.
45. Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006; 103:12481-12486. (Pubitemid 44267285)
46. PerryMM, Moschos SA, Williams AE, et al. Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells. J Immunol 2008; 180:5689-5698.
47. Xiao C, Calado DP, Galler G, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 2007; 131:146-159. (Pubitemid 47498525)
48. Pykalainen M, Kinos R, Valkonen S, et al. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol 2005; 115:80-87. (Pubitemid 40075425)
49. Vasilescu C, Rossi S, Shimizu M, et al. MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One 2009; 4:e7405.
50. Baltimore D, Boldin MP, O'Connell RM, et al. New regulators of immune cell development and function. Nat Immunol 2008; 9:839-845. (Pubitemid 352038302)
51. Li QJ, Chau J, Ebert PJ, et al. miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 2007; 129:147-161. (Pubitemid 46507589)
52. Ebert PJ, Jiang S, Xie J, et al. An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol 2009; 10:1162-1169.