Comparison of in-vivo and in-silico methods used for prediction of tissue: Plasma partition coefficients in rat

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 3, 2012, Pages 383-396

  Graham, Helen ^a   Walker, Mike ^b   Jones, Owen ^b   Yates, James ^b   Galetin, Aleksandra ^a   Aarons, Leon ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

in silico prediction; partition coefficients; pharmacokinetics

Indexed keywords

ACCURACY; ADIPOSE TISSUE; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CALCULATION; COMPUTER MODEL; CONTROLLED STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; RAT; TISSUE CHARACTERIZATION; TISSUE DISTRIBUTION; TISSUE SPECIFICITY;

ANIMALS; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHYSICOCHEMICAL PHENOMENA; PLASMA; PREDICTIVE VALUE OF TESTS; RATS; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

EID: 84857061411     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01429.x     Document Type: Article

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