Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease

Cell Death and Differentiation

Volumn 19, Issue 3, 2012, Pages 416-427

  Lim, L ^a   Jackson Lewis, V ^b   Wong, L C ^c   Shui, G H ^d   Goh, A X H ^d   Kesavapany, S ^d   Jenner, A M ^d,f   Fivaz, M ^c,d   Przedborski, S ^b   Wenk, M R ^a,d,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF BASEL   (Switzerland)

^f UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

dopaminergic neruons; lanosterol; lipids; mitochondrial membrane potential; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; LANOSTEROL; LANOSTEROL SYNTHASE; STEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BRAIN MITOCHONDRION; BRAIN REGION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DEPOLARIZATION; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; ENDOPLASMIC RETICULUM; HOMEOSTASIS; MESENCEPHALON; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; STEROL METABOLISM;

ANIMALS; CELL DEATH; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; HUMANS; LANOSTEROL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MPTP POISONING;

MUS;

EID: 84857039975     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.105     Document Type: Article

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