Induction of CD4 CD25 Foxp3 regulatory T cells by Thy-1 stimulation of CD4 T cells

Immunology and Cell Biology

Volumn 90, Issue 2, 2012, Pages 248-252

  Conrad, David M ^a   Coombs, Melanie R Power ^a   Furlong, Suzanne J ^a   Forward, Nicholas A ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Foxp3; interleukin 10; interleukin 2; regulatory T cell; Thy 1

Indexed keywords

5' NUCLEOTIDASE; CD39 ANTIGEN; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3; THY 1 ANTIGEN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CROSS LINKING; DENDRITIC CELL; GENE EXPRESSION; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, THY-1; APYRASE; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 84857034555     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2011.33     Document Type: Article

References (25)

1. Haeryfar SM, Hoskin DW. Thy-1: more than a mouse pan-T cell marker. J Immunol 2004; 173: 3581-3588. (Pubitemid 39280715)
2. Kroczek RA, Gunter KC, Seligmann B, Shevach EM. Induction of T cell activation by monoclonal anti-Thy-1 antibodies. J Immunol 1986; 136: 4379-4384. (Pubitemid 16090649)
3. Haeryfar SM, Al-Alwan MM, Mader JS, Rowden G, West KA, Hoskin DW. Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit. J Immunol 2003; 171: 69-77. (Pubitemid 36745274)
4. Conrad DM, Furlong SJ, Doucette CD, Boudreau RTM, Hoskin DW. Role of mitogenactivated protein kinases in Thy-1-induced T-lymphocyte activation. Cell Signal 2009; 21: 1298-1307.
5. Hueber AO, Bernard AM, Battari CL, Marguet D, Massol P, Foa C et al. Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation. Curr Biol 1997; 7: 705-708.
6. Becker C, Stoll S, Bopp T, Schmitt E, Jonuleit H. Regulatory T cells: present facts and future hopes. Med Microbiol Immunol 2006; 195: 113-124. (Pubitemid 44421171)
7. Chen W, Jin W, Hardegen N, Lei K, Li L, Marinos N et al. Conversion of peripheral CD4+CD25 naïve T cells to CD4+CD25+ regulatory T cells by TGF-b induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875-1886. (Pubitemid 38032120)
8. Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W. A critical function for TGF-b signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol 2008; 9: 632-640. (Pubitemid 351712634)
9. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336. (Pubitemid 36432314)
10. Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T et al. Foxp3 controls regulatory T cell function by interacting with AML1/Runx1. Nature 2007; 446: 685-689. (Pubitemid 46606883)
11. Shevach EM. Mechanisms of Foxp3+ T regulatory cell-mediated suppression. Immunity 2009; 30: 636-645.
12. Ernst PB, Garrison JC, Thompson LF. Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J Immunol 2010; 185: 1993-1998.
13. Leyton L, Quest AF, Bron C. Thy-1/CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT. Mol Immunol 1999; 36: 755-768. (Pubitemid 29526918)
14. Koonpaew S, Shen S, Flowers L, Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med 2006; 203: 119-129. (Pubitemid 43139651)
15. Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998; 188: 287-296. (Pubitemid 28357757)
16. de la Rosa M, Rutz S, Dorninger H, Scheffold A. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol 2004; 34: 2480-2488. (Pubitemid 39302805)
17. Groux H. Type 1 T-regulatory cells: their role in the control of immune responses. Transplantation 2003; 75(9 Suppl): 8S-12S. (Pubitemid 36593076)
18. Curotto de Lafaille M, Lafaille JJ. Natural and adaptive Foxp3+ regulatory T cells : more of the same or a division of labor? Immunity 2009; 30: 626-635.
19. Deaglio S, Dwyer KM, Gao W, Friedman A, Usheva A, Erat A, Chen JF et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204: 1257-1265. (Pubitemid 46919862)
20. Kingsley CI, Karim M, Bushell AR, Wood KJ. CD25+ CD4+ regulatory T cells prevent graft rejection: CTLA-4-and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002; 168: 1080-1086. (Pubitemid 34094471)
21. Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000; 164: 183-190. (Pubitemid 30012989)
22. Bettelli E, Dastrange M, Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kB to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci USA 2005; 102: 5138-5143.
23. Duthoit CT, Mekala DJ, Alli RS, Geiger TL. Uncoupling of IL-2 signaling from cell cycle progression in resting CD4+ T cells by regulatory CD4+CD25+ T lymphocytes. J Immunol 2005; 174: 155-163. (Pubitemid 40007401)
24. Zhang H, Conrad DM, Butler JJ, Zhao C, Blay J, Hoskin DW. Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes: role of cyclic adenosine 3',5'-monophosphate and phosphatases. J Immunol 2004; 173: 932-944. (Pubitemid 38924266)
25. Forward NA, Furlong SJ, Yang Y, Lin T-J, Hoskin DW. Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells. J Leukoc Biol 2010; 87: 117-125.