-
1
-
-
33745032291
-
Water mediation in protein folding, molecular recognition
-
Levy Y., Onuchic J. Water mediation in protein folding, molecular recognition. Annu. Rev. Biophys. Biomol. Struct. 2006, 35:389-415.
-
(2006)
Annu. Rev. Biophys. Biomol. Struct.
, vol.35
, pp. 389-415
-
-
Levy, Y.1
Onuchic, J.2
-
3
-
-
67650078274
-
Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation
-
Ishimaru D., Ano Bom A.P.D., Lima L.M.T.R., Quesado P.A., Oyama M.F.C., de Moura Gallo C.V., Cordeiro Y., Silva J.L. Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation. Biochemistry 2009, 48(26):6126-6135.
-
(2009)
Biochemistry
, vol.48
, Issue.26
, pp. 6126-6135
-
-
Ishimaru, D.1
Ano Bom, A.P.D.2
Lima, L.M.T.R.3
Quesado, P.A.4
Oyama, M.F.C.5
de Moura Gallo, C.V.6
Cordeiro, Y.7
Silva, J.L.8
-
4
-
-
64549105630
-
Structural biology of the p53 tumour suppressor
-
Okorokov A.L., Orlova E.V. Structural biology of the p53 tumour suppressor. Curr. Opin. Cell Biol. 2009, 19:197-202.
-
(2009)
Curr. Opin. Cell Biol.
, vol.19
, pp. 197-202
-
-
Okorokov, A.L.1
Orlova, E.V.2
-
5
-
-
67651151100
-
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core
-
Khoo K.H., Joerger A.C., Freund S., Fersht A.R. Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core. Protein Eng. Des. Sel. 2009, 22(7):421-430.
-
(2009)
Protein Eng. Des. Sel.
, vol.22
, Issue.7
, pp. 421-430
-
-
Khoo, K.H.1
Joerger, A.C.2
Freund, S.3
Fersht, A.R.4
-
6
-
-
33144474649
-
Solution structure of p53 core domain: structural basis for its instability
-
Cañadillas J.M.P., Tidow H., Freund S., Rutherford T., Ang H.C., Fersht A.R. Solution structure of p53 core domain: structural basis for its instability. Proc. Natl. Acad. Sci. USA 2006, 103(7):2109-2114.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.7
, pp. 2109-2114
-
-
Cañadillas, J.M.P.1
Tidow, H.2
Freund, S.3
Rutherford, T.4
Ang, H.C.5
Fersht, A.R.6
-
7
-
-
0036674617
-
Live or let die: the cell's response to p53
-
Vousden K.H., Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2002, 2:594-604.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
8
-
-
77249149930
-
Ligand binding, hydration in protein misfolding: Insights from studies of Prion, p53 tumor suppressor proteins
-
Silva J.L., Vieira T.C.R.G., Gomes M.P.B., Bom A.P.A., Lima L.M.T.R., Freitas M.S., Ishimaru D., Cordeiro Y., Foguel D. Ligand binding, hydration in protein misfolding: Insights from studies of Prion, p53 tumor suppressor proteins. Acc. Chem. Res. 2010, 43(2):271-279.
-
(2010)
Acc. Chem. Res.
, vol.43
, Issue.2
, pp. 271-279
-
-
Silva, J.L.1
Vieira, T.C.R.G.2
Gomes, M.P.B.3
Bom, A.P.A.4
Lima, L.M.T.R.5
Freitas, M.S.6
Ishimaru, D.7
Cordeiro, Y.8
Foguel, D.9
-
9
-
-
0042666825
-
Fibrillar aggregates of the tumor suppressor p53 core domain
-
Ishimaru D., Andrade L.R., Teixeira L.S.P., Quesado P.A., Maiolino L.M., Lopez P.M., Cordeiro Y., Costa L.T., Heckl W.M., Weissmüller G., Foguel D., Silva J.L. Fibrillar aggregates of the tumor suppressor p53 core domain. Biochemistry 2003, 42:9022-9027.
-
(2003)
Biochemistry
, vol.42
, pp. 9022-9027
-
-
Ishimaru, D.1
Andrade, L.R.2
Teixeira, L.S.P.3
Quesado, P.A.4
Maiolino, L.M.5
Lopez, P.M.6
Cordeiro, Y.7
Costa, L.T.8
Heckl, W.M.9
Weissmüller, G.10
Foguel, D.11
Silva, J.L.12
-
10
-
-
0038425042
-
Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis
-
Fernández A., Scheraga H.A. Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis. Proc. Natl. Acad. Sci. USA 2003, 100:113-118.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 113-118
-
-
Fernández, A.1
Scheraga, H.A.2
-
11
-
-
0037975647
-
Structural defects, the diagnosis of amyloidogenic propensity
-
Fernández A., Kardos J., Scott L.R., Goto Y., Berry R.S. Structural defects, the diagnosis of amyloidogenic propensity. Proc. Natl. Acad. Sci. USA 2003, 100:6446-6451.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6446-6451
-
-
Fernández, A.1
Kardos, J.2
Scott, L.R.3
Goto, Y.4
Berry, R.S.5
-
12
-
-
4143134381
-
Inhibitor design by wrapping packing defects in HIV-1 proteins
-
Fernández A., Rogale K., Scott R., Scheraga H.A. Inhibitor design by wrapping packing defects in HIV-1 proteins. Proc. Natl. Acad. Sci. USA 2004, 101:11640-11645.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 11640-11645
-
-
Fernández, A.1
Rogale, K.2
Scott, R.3
Scheraga, H.A.4
-
13
-
-
79952456642
-
Dynamic communication between androgen and coactivator: mutually-induced conformational perturbations in androgen receptor ligand-binding domain
-
Xu X., Yang W., Wang X., Li Y., Wang Y., Ai C. Dynamic communication between androgen and coactivator: mutually-induced conformational perturbations in androgen receptor ligand-binding domain. Proteins. 2011, 79(4):1154-1171.
-
(2011)
Proteins.
, vol.79
, Issue.4
, pp. 1154-1171
-
-
Xu, X.1
Yang, W.2
Wang, X.3
Li, Y.4
Wang, Y.5
Ai, C.6
-
14
-
-
79951778220
-
Two TPX2-dependent switches control the activity of Aurora A
-
Xu X., Wang X., Xiao Z., Li Y., Wang Y.H. Two TPX2-dependent switches control the activity of Aurora A. PLoS One 2011, 6(2):e16757.
-
(2011)
PLoS One
, vol.6
, Issue.2
-
-
Xu, X.1
Wang, X.2
Xiao, Z.3
Li, Y.4
Wang, Y.H.5
-
15
-
-
0347760067
-
Dynamics of protein, peptide hydration
-
Modig K., Liepinsh E., Otting G., Halle B. Dynamics of protein, peptide hydration. J. Am. Chem. Soc. 2004, 126:102-114.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 102-114
-
-
Modig, K.1
Liepinsh, E.2
Otting, G.3
Halle, B.4
-
16
-
-
19644385843
-
Prion, water: tight, dynamical hydration sites have a key role in structural stability
-
De Simone A., Dodson G.G., Verma C.S., Zagari A., Fraternali F. Prion, water: tight, dynamical hydration sites have a key role in structural stability. Proc. Natl. Acad. Sci. USA 2005, 102(21):7535-7540.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, Issue.21
, pp. 7535-7540
-
-
De Simone, A.1
Dodson, G.G.2
Verma, C.S.3
Zagari, A.4
Fraternali, F.5
-
17
-
-
1542618345
-
Water in protein structure prediction
-
Papoian G.A., Ulander J., Eastwood M.P., Luthey-Schulten Z., Wolynes P.G. Water in protein structure prediction. Proc. Natl. Acad. Sci. USA 2004, 101:3352-3357.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 3352-3357
-
-
Papoian, G.A.1
Ulander, J.2
Eastwood, M.P.3
Luthey-Schulten, Z.4
Wolynes, P.G.5
-
18
-
-
33745209412
-
Structural basis of DNA recognition by p53 tetramers
-
Kitayner M., Rozenberg H., Kessler N., Rabinovich D., Shaulov L., Haran T.E., Shakked Z. Structural basis of DNA recognition by p53 tetramers. Mol. Cell 2006, 22:741-753.
-
(2006)
Mol. Cell
, vol.22
, pp. 741-753
-
-
Kitayner, M.1
Rozenberg, H.2
Kessler, N.3
Rabinovich, D.4
Shaulov, L.5
Haran, T.E.6
Shakked, Z.7
-
19
-
-
4444354635
-
Keeping dry, crossing membranes
-
Fernández A. Keeping dry, crossing membranes. Nat. Biotechnol. 2004, 22(9):1081-1084.
-
(2004)
Nat. Biotechnol.
, vol.22
, Issue.9
, pp. 1081-1084
-
-
Fernández, A.1
-
20
-
-
75149134332
-
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant
-
Basse N., Kaar J.L., Settanni G., Joerger A.C., Rutherford T.J., Fersht A.R. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem. Biol. 2010, 17:46-56.
-
(2010)
Chem. Biol.
, vol.17
, pp. 46-56
-
-
Basse, N.1
Kaar, J.L.2
Settanni, G.3
Joerger, A.C.4
Rutherford, T.J.5
Fersht, A.R.6
-
21
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
-
Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 1994, 265(5170):346-355.
-
(1994)
Science
, vol.265
, Issue.5170
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
22
-
-
33746714410
-
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines
-
Wasielewski M., Elstrodt F., Klijn J.G.M., Berns Els.M.J.J., Schutte M. Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines. Breast Cancer Res. Treat. 2006, 99:97-101.
-
(2006)
Breast Cancer Res. Treat.
, vol.99
, pp. 97-101
-
-
Wasielewski, M.1
Elstrodt, F.2
Klijn, J.G.M.3
Berns, E.4
Schutte, M.5
-
23
-
-
38049053608
-
Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements
-
Ma B., Levine A.J. Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements. Nucl. Acids Res. 2007, 35(22):7733-7747.
-
(2007)
Nucl. Acids Res.
, vol.35
, Issue.22
, pp. 7733-7747
-
-
Ma, B.1
Levine, A.J.2
-
24
-
-
68049087927
-
Protein hydration dynamics, molecular mechanism of coupled water-protein fluctuations
-
Zhang L., Yang Y., Kao Y., Wang L., Zhong D. Protein hydration dynamics, molecular mechanism of coupled water-protein fluctuations. J. Am. Chem. Soc. 2009, 131:10677-10691.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 10677-10691
-
-
Zhang, L.1
Yang, Y.2
Kao, Y.3
Wang, L.4
Zhong, D.5
-
25
-
-
0030928507
-
Inactivation of the p53 protein in cell lines derived from human esophageal cancers
-
Barnas C., Martel-Planche G., Furukawa Y., Hollstein M., Montesano R., Hainaut P. Inactivation of the p53 protein in cell lines derived from human esophageal cancers. Int. J. Cancer 1997, 71(1):79-87.
-
(1997)
Int. J. Cancer
, vol.71
, Issue.1
, pp. 79-87
-
-
Barnas, C.1
Martel-Planche, G.2
Furukawa, Y.3
Hollstein, M.4
Montesano, R.5
Hainaut, P.6
-
26
-
-
0033636839
-
Residence times of water molecules in the hydration sites of myoglobin
-
Makarov V.A., Andrews B.K., Smith P.E., Pettitt B.M. Residence times of water molecules in the hydration sites of myoglobin. Biophys. J. 2000, 79:2966-2974.
-
(2000)
Biophys. J.
, vol.79
, pp. 2966-2974
-
-
Makarov, V.A.1
Andrews, B.K.2
Smith, P.E.3
Pettitt, B.M.4
-
27
-
-
33846417622
-
Protein dynamics tightly connected to the dynamics of surrounding, internal water molecules
-
Helms V. Protein dynamics tightly connected to the dynamics of surrounding, internal water molecules. Chem. Phys. Chem. 2007, 8:23-33.
-
(2007)
Chem. Phys. Chem.
, vol.8
, pp. 23-33
-
-
Helms, V.1
-
28
-
-
0031473847
-
SWISS-MODEL, the Swiss-Pdb Viewer: an environment for comparative protein modeling
-
Guex N., Peitsch M.C. SWISS-MODEL, the Swiss-Pdb Viewer: an environment for comparative protein modeling. Electrophoresis 1997, 18:2714-2723.
-
(1997)
Electrophoresis
, vol.18
, pp. 2714-2723
-
-
Guex, N.1
Peitsch, M.C.2
-
30
-
-
0001751804
-
Reversible peptide folding in solution by molecular dynamics simulation1
-
Daura X., Mark A.E., van Gunsteren W.F. Reversible peptide folding in solution by molecular dynamics simulation1. J. Comp. Chem. 1998, 19:535-547.
-
(1998)
J. Comp. Chem.
, vol.19
, pp. 535-547
-
-
Daura, X.1
Mark, A.E.2
van Gunsteren, W.F.3
-
31
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
Jorgensen W.L., Chandrasekhar J., Madura J.D., Klein M.L. Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 1983, 79:926-935.
-
(1983)
J. Chem. Phys.
, vol.79
, pp. 926-935
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Madura, J.D.3
Klein, M.L.4
-
32
-
-
33750587438
-
Molecular dynamics with coupling to an external bath
-
Berendsen H.J.C., Postma J.P.M., van Gunsteren W.F., DiNola A., Haak J.R. Molecular dynamics with coupling to an external bath. J. Chem. Phys. 1984, 81:3684-3690.
-
(1984)
J. Chem. Phys.
, vol.81
, pp. 3684-3690
-
-
Berendsen, H.J.C.1
Postma, J.P.M.2
van Gunsteren, W.F.3
DiNola, A.4
Haak, J.R.5
-
33
-
-
0000388705
-
A linear constraint solver for molecular simulations
-
Hess B., Bekker H., Berendsen H.J.C., Fraaije J.G.E. A linear constraint solver for molecular simulations. J. Comput. Chem. 1997, 18:1463-1472.
-
(1997)
J. Comput. Chem.
, vol.18
, pp. 1463-1472
-
-
Hess, B.1
Bekker, H.2
Berendsen, H.J.C.3
Fraaije, J.G.E.4
-
34
-
-
33846823909
-
Particle mesh Ewald: an N log (N) method for Ewald sums in large systems
-
Darden T., York D., Pedersen L. Particle mesh Ewald: an N log (N) method for Ewald sums in large systems. J. Chem. Phys. 1993, 98:10089-10092.
-
(1993)
J. Chem. Phys.
, vol.98
, pp. 10089-10092
-
-
Darden, T.1
York, D.2
Pedersen, L.3
-
35
-
-
0027957222
-
Distribution function implied dynamics versus residence times, correlations: solvation shells of myoglobin
-
Lounnas V., Pettitt B.M. Distribution function implied dynamics versus residence times, correlations: solvation shells of myoglobin. Proteins 1994, 18:148-160.
-
(1994)
Proteins
, vol.18
, pp. 148-160
-
-
Lounnas, V.1
Pettitt, B.M.2
-
36
-
-
0028144626
-
Connected-cluster of hydration around myoglobin: correlation between molecular dynamics simulations, experiment
-
Lounnas V., Pettitt B.M.A. Connected-cluster of hydration around myoglobin: correlation between molecular dynamics simulations, experiment. Proteins 1994, 18:133-147.
-
(1994)
Proteins
, vol.18
, pp. 133-147
-
-
Lounnas, V.1
Pettitt, B.M.A.2
-
37
-
-
2942659093
-
Standard free energy of releasing a localized water molecule from the binding pockets of proteins: double-decoupling method
-
Hamelberg D., McCammon J.A. Standard free energy of releasing a localized water molecule from the binding pockets of proteins: double-decoupling method. J. Am. Chem. Soc. 2004, 126:7683-7689.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 7683-7689
-
-
Hamelberg, D.1
McCammon, J.A.2
|