Inhibitor design by wrapping packing defects in HIV-1 proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 32, 2004, Pages 11640-11645

  Fernández, Ariel ^a,b   Rogale, Kristina ^d   Scott, Ridgway ^b,c   Scheraga, Harold A ^e  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d PRINCETON UNIVERSITY   (United States)

^e Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; PROTEINASE; VIRUS PROTEIN; WATER;

ARTICLE; BINDING SITE; CATALYSIS; DEHYDRATION; DRUG TARGETING; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; FELINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MICROENVIRONMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRION; VIRUS ASSEMBLY;

CATALYTIC DOMAIN; DRUG DESIGN; ELECTROSTATICS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV PROTEASE; HIV PROTEASE INHIBITORS; PROTEIN CONFORMATION; RETROVIRIDAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

FELIDAE; FELINE IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 4143134381     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404641101     Document Type: Article

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