Adsorptive loss of secreted recombinant proteins in transgenic rice cell suspension cultures

Plant Cell Reports

Volumn 31, Issue 3, 2012, Pages 551-560

  Kwon, Jun Young ^a   Lee, Kyoung Hoon ^a   Cheon, Su Hwan ^a   Ryu, Hyun Nam ^a   Kim, Sun Jin ^b   Kim, Dong Il ^a  

^a Inha University   (South Korea)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Fc fusion protein; hCTLA4Ig; Protein adsorption; Spiking test; Transgenic rice cell culture

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; GLASS; IMMUNOSUPPRESSIVE AGENT; PLASTIC; RECOMBINANT PROTEIN;

ADSORPTION; ARTICLE; CELL CULTURE; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; PLANT CELL; PROTEIN STABILITY; RICE; SECRETION (PROCESS); SURFACE PROPERTY; TRANSGENIC PLANT;

ADSORPTION; CELL CULTURE TECHNIQUES; CELLS, CULTURED; GLASS; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; ORYZA SATIVA; PLANT CELLS; PLANTS, GENETICALLY MODIFIED; PLASTICS; PROTEIN STABILITY; RECOMBINANT PROTEINS; SURFACE PROPERTIES;

BOVINAE;

EID: 84856954298     PISSN: 07217714     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00299-011-1184-x     Document Type: Article

References (41)

1. Abu-Absi SF, Yang L, Thompson P, Jiang C, Kandula S, Schilling B, Shukla AA (2010) Defining process design space for monoclonal antibody cell culture. Biotechnol Bioeng 106: 894-905.
2. Andrade JD, Hlady V (1986) Protein adsorption and materials biocompatibility. Adv Polym Sci 79: 1-63.
3. Bee JS, Davies M, Freund E, Carpenter JF, Randoplh TW (2009) Aggregation of a monoclonal antibody induced by adsorption to stainless steel. Biotechnol Bioeng 105: 121-129.
4. Biddlecombe JG, Craig AV, Zhang H, Uddin S, Mulot S, Fish BC, Bracewell DG (2007) Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment. Biotechnol Prog 23: 1218-1222.
5. Calinski A, Classen B, Zoglauer K, Boehm R (2009) IgG stability in fresh and conditioned medium of tobacco (Nicotiana tabacum) and larch (Larix decidua) embryogenic suspension cultures. Biotechnol Lett 31: 771-778.
6. Chen TL, Lin YL, Lee YL, Yang NS, Chan MT (2004) Expression of bioactive human interferon-gamma in transgenic rice cell suspension cultures. Transgenic Res 13: 499-510.
7. Doran PM (2006) Loss of secreted antibody from transgenic plant tissue cultures due to surface adsorption. J Biotechnol 122: 39-54.
8. Fu LH, Miao Y, Lo SW, Seto TC, Sun SSM, Xu ZF, Clemens S, Clarke L, Kermode AR, Jiang L (2009) Production and characterization of soluble human lysosomal enzyme α-iduronidase with high activity from culture media of transgenic tobacco BY-2 cells. Plant Sci 177: 668-675.
9. Girard LS, Fabis MJ, Bastin M, Courtois D, Petiard V, Koprowski H (2006) Expression of a human anti-rabies virus monoclonal antibody in tobacco cell culture. Biochem Biophys Res Commun 345: 602-607.
10. Hellwig S, Drossard J, Twyman RM, Fischer R (2004) Plant cell cultures for the production of recombinant proteins. Nat Biotechnol 22: 1415-1422.
11. Holland T, Sack M, Rademacher T, Schmale K, Altmann F, Stadlmann J, Fischer R, Hellwig S (2010) Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture. Biotechnol Bioeng 107: 278-289.
12. Horbett TA, Brash JL (1987) Protein at interfaces: current issues and future prospects. In: Brash JL, Horbett TA (eds) Proteins at interfaces: physiochemical and biochemical studies. American Chemical Society, pp 1-33.
13. Huang N, Chandler J, Thomas BR, Koizumi N, Rodriguez RL (1993) Metabolic regulation of α-amylase gene expression in transgenic cell cultures of rice (Oryza sativa L.). Plant Mol Biol 23: 737-747.
14. Huang TK, Plesha MA, Falk BW, Dandekar AM, McDonald KA (2009) Bioreactor strategies for improving production yield and functionality of a recombinant human protein in transgenic tobacco cell cultures. Biotechnol Bioeng 102: 508-520.
15. Imamura K, Shimomura M, Nagai S, Akamatsu M, Nakanish K (2008) Adsorption characteristics of various proteins to a titanium surface. J Biosci Bioeng 106: 273-278.
16. James E, Wang C, Wang Z, Reeves R, Shin JH, Magnuson NS, Lee JM (2000) Production and characterization of biologically active human GM-CSF secreted by genetically modified plant cells. Protein Expr Purif 19: 131-138.
17. James E, Mills DR, Lee JM (2002) Increased production and recovery of secreted foreign proteins from plant cell cultures using an affinity chromatography bioreactor. Biochem Eng J 12: 205-213.
18. Kwon TH, Seo JE, Kim J, Lee JH, Jang YS, Yang MS (2003) Expression and secretion of the heterodimeric protein interleukin-12 in plant cell suspension culture. Biotechnol Bioeng 81: 870-875.
19. LaCount W, An G, Lee JM (1997) The effect of polyvinylpyrrolidone (PVP) on the heavy chain monoclonal antibody production from plant suspension cultures. Biotechnol Lett 19: 93-96.
20. Lee SY, Kim DI (2002) Stimulation of murine granulocyte macrophage-colony stimulating factor production by Pluronic F-68 and polyethylene glycol in transgenic Nicotiana tabacum cell culture. Biotechnol Lett 24: 1779-1783.
21. Lee GM, Huard TK, Palsson BO (1988) Effect of anchorage dependency on growth rate and monoclonal antibody production of hybridoma cells. Biotechnol Lett 10: 307-312.
22. Lee JH, Kim NS, Kwon TH, Jang YS, Yang MS (2002) Increased production of human granulocyte-macrophage colony simulating factor (hGM-CSF) by the addition of stabilizing polymer in plant suspension cultures. J Biotechnol 96: 205-211.
23. Lee SJ, Park CI, Park MI, Jung HS, Ryu WS, Lim SM, Tan HK, Kwon TH, Yang MS, Kim DI (2007) Production and characterization of human CTLA4Ig expressed in transgenic rice cell suspension cultures. Protein Expr Purif 51: 293-302.
24. Leitao E, Barbosa MA (1998) In vitro testing of surface-modified biomaterials. J Mater Sci Mater Med 8: 543-548.
25. Magnuson NS, Linzmaier PM, Gao JW, Reeves R, An G, Lee JM (1996) Enhanced recovery of a secreted mammalian protein from suspension culture of genetically modified tobacco cells. Protein Expr Purif 7: 220-228.
26. 1-antitrypsin from transgenic rice cell culture in a membrane bioreactor. Biotechnol Prog 21: 728-734.
27. Nakanishi K, Sakiyama T, Imamura K (2001) On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon. J Biosci Bioeng 91: 233-244.
28. Outchkourov NS, Rogelj B, Strukelj B, Jongsma MA (2003) Expression of sea anemone equistatin in potato. Effects of plant proteases on heterologous protein production. Plant Physiol 133: 379-390.
29. Park CI, Lee SJ, Kang SH, Jung HS, Kim DI, Lim SM (2010) Fed-batch cultivation of transgenic rice cells for the production of hCTLA4Ig using concentrated amino acids. Process Biochem 45: 67-74.
30. Ratner M (2010) Pfizer stakes a claim in plant cell-made biopharmaceuticals. Nat Biotechnol 28: 107-108.
31. Schiermeyer A, Schinkel H, Apel S, Fischer R, Schillberg S (2005) Production of desmodus rotundus salivary plasminogen activator α1 (DSPAα1) in tobacco is hampered by proteolysis. Biotechnol Bioeng 89: 848-858.
32. Sharma N, Park SM, Kwon TH, Kim DH, Yang MS (2004) A simple purification procedure of biologically active recombinant human granulocyte macrophage colony stimulating factor (hGM-CSF) secreted in rice cell suspension culture. Biotechnol Bioprocess Eng 9: 423-427.
33. Sharma N, Kim TG, Yang MS (2006) Production and secretion of human interleukin-18 in transgenic tobacco cell suspension culture. Biotechnol Bioprocess Eng 11: 154-159.
34. Sharp JM, Doran PM (2001) Strategies for enhancing monoclonal antibody accumulation in plant cell and organ cultures. Biotechnol Prog 17: 979-992.
35. Shin YJ, Hong SY, Kwon TH, Jang YS, Yang MS (2003) High level of expression of recombinant granulocyte-macrophage colony stimulating factor in transgenic rice cell suspension culture. Biotechnol Bioeng 82: 778-783.
36. Simmons CR, Huang N, Cao Y, Rodriguez RL (1991) Synthesis and secretion of α-amylase by rice callus: evidence for differential gene expression. Biotechnol Bioeng 38: 545-551.
37. Stevens LH, Stoopen GM, Elbers IJW, Molthoff JW, Bakker HAC, Lommen A, Bosch D, Jordi W (2000) Effect of climate conditions and plant developmental stage on the stability of antibodies expressed in transgenic tobacco. Plant Physiol 124: 173-182.
38. 1-antitrypsin by plant cell culture. Appl Microbiol Biotechnol 52: 516-523.
39. Tsoi BM, Doran PM (2002) Effect of medium properties and additives on antibody stability and accumulation in suspended plant cell cultures. Biotechnol Appl Biochem 35: 171-180.
40. Xu J, Ge X, Dolan MC (2011) Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures. Biotechnol Adv 29: 278-299.
41. Zhang F, Kang ET, Neoh KG, Wang P, Tan KL (2001) Surface modification of stainless steel by grafting of poly (ethyleneglycol) for reduction in protein adsorption. Biomaterials 22: 1541-1548.