Regulators of osteoclast differentiation and cell-cell fusion

Keio Journal of Medicine

Volumn 60, Issue 4, 2011, Pages 101-105

  Miyamoto, Takeshi ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Bcl6; Blimp1; DC STAMP; Osteoclasts

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CATHEPSIN K; DENDRITIC CELL SPECIFIC TRANSMEMBRANE PROTEIN; MACROPHAGE FUSION RECEPTOR; MESSENGER RNA; NUCLEAR FACTOR OF ACTIVATED T CELL 1; PROTEIN; PROTEIN BCL 6; PROTEIN C FOS; RECEPTOR; UNCLASSIFIED DRUG; UVOMORULIN;

BONE MASS; CELL FUSION; COCULTURE; FRANKLINIELLA; GENE EXPRESSION; GIANT CELL; HOMEOSTASIS; MACROPHAGE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN EXPRESSION; REVIEW; STEM CELL;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL FUSION; HOMEOSTASIS; HUMANS; MEMBRANE PROTEINS; OSTEOCLASTS; RANK LIGAND;

EID: 84856925503     PISSN: 00229717     EISSN: 18801293     Source Type: Journal    
DOI: 10.2302/kjm.60.101     Document Type: Review

References (29)

1. Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF: c-Fos: a key regulator of osteoclast- macrophage lineage determination and bone remodeling. Science 1994; 266: 443-448. [Medline] [CrossRef]
2. Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S: The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990; 345: 442-444. [Medline] [CrossRef]
3. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397: 315-323. [Medline] [CrossRef]
4. Rodan GA: Introduction to bone biology. Bone 1992; 13(Suppl 1): S3-S6. [Medline] [CrossRef]
5. Nosaka K, Miyamoto T, Sakai T, Mitsuya H, Suda T, Matsuoka M: Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. Blood 2002; 99: 634-640. [Medline] [CrossRef]
6. Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997; 390: 175-179. [Medline] [CrossRef]
7. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998; 93: 165-176. [Medline] [CrossRef]
8. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T: Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/ RANKL. Proc Natl Acad Sci USA 1998; 95: 3597-3602. [Medline] [CrossRef]
9. Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS 3rd, Frankel WN, Lee SY, Choi Y: TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 1997; 272: 25190-25194. [Medline] [CrossRef]
10. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T: Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 1988; 122: 1373-1382. [Medline][CrossRef]
11. Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T: Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med 1999; 190: 1741-1754. [Medline] [CrossRef]
12. Miyamoto T, Arai F, Ohneda O, Takagi K, Anderson DM, Suda T: An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand. Blood 2000; 96: 4335-4343. [Medline]
13. Miyamoto T, Ohneda O, Arai F, Iwamoto K, Okada S, Takagi K, Anderson DM, Suda T: Bifurcation of osteoclasts and dendritic cells from common progenitors. Blood 2001; 98: 2544-2554. [Medline] [CrossRef]
14. Yagi M, Miyamoto T, Sawatani Y, Iwamoto K, Hosogane N, Fujita N, Morita K, Ninomiya K, Suzuki T, Miyamoto K, Oike Y, Takeya M, Toyama Y, Suda T: DC-STAMP is essential for cell- cell fusion in osteoclasts and foreign body giant cells. J Exp Med 2005; 202: 345-351. [Medline] [CrossRef]
15. Hartgers FC, Vissers JL, Looman MW, van Zoelen C, Huffine C, Figdor CG, Adema GJ: DC-STAMP, a novel multimembrane- spanning molecule preferentially expressed by dendritic cells. Eur J Immunol 2000; 30: 3585-3590. [Medline] [CrossRef]
16. Staege H, Brauchlin A, Schoedon G, Schaffner A: Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. Immunogenetics 2001; 53: 105-113. [Medline] [CrossRef]
17. Kukita T, Wada N, Kukita A, Kakimoto T, Sandra F, Toh K, Nagata K, Iijima T, Horiuchi M, Matsusaki H, Hieshima K, Yoshie O, Nomiyama H: RANKL-induced DC-STAMP is essential for osteoclastogenesis. J Exp Med 2004; 200: 941-946. [Medline] [CrossRef]
18. Yagi M, Ninomiya K, Fujita N, Suzuki T, Iwasaki R, Morita K, Hosogane N, Matsuo K, Toyama Y, Suda T, Miyamoto T:Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J Bone Miner Res 2007; 22: 992-1001. [Medline] [CrossRef]
19. Iwasaki R, Ninomiya K, Miyamoto K, Suzuki T, Sato Y, Kawana H, Nakagawa T, Suda T, Miyamoto T: Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity. Biochem Biophys Res Commun 2008; 377: 899-904. [Medline] [CrossRef]
20. Lee SH, Rho J, Jeong D, Sul JY, Kim T, Kim N, Kang JS, Miyamoto T, Suda T, Lee SK: Pignolo RJ, Koczon-Jaremko B, Lorenzo J, Choi Y. v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med 2006; 12: 1403-1409. [Medline] [CrossRef]
21. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T: Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 2002; 3: 889-901. [Medline] [CrossRef]
22. Kim K, Lee SH, Ha Kim J, Choi Y, Kim N: NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol 2008; 22: 176-185. [Medline] [CrossRef]
23. Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, Morita I, Wagner EF, Mak TW, Serfling E, Takayanagi H: Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 2005; 202: 1261-1269. [Medline] [CrossRef]
24. Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, Takayanagi H: NFAT and Osterix cooperatively regulate bone formation. Nat Med 2005; 11: 880-885. [Medline] [CrossRef]
25. Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T: Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004; 428: 758-763. [Medline] [CrossRef]
26. Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T: The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med 2010; 207: 751-762. [Medline] [CrossRef]
27. Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H: Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci USA 2010; 107: 3117-3122. [Medline] [CrossRef]
28. Kim K, Kim JH, Lee J, Jin HM, Kook H, Kim KK, Lee SY, Kim N: MafB negatively regulates RANKL-mediated osteoclast differentiation. Blood 2007; 109: 3253-3259. [Medline] [CrossRef]
29. Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R: Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med 2009; 15: 1066-1071. [Medline] [CrossRef]