Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Gu, Rong ^a   Bai, Jian ^a   Ling, Lin ^a   Ding, Liang ^a   Zhang, Na ^a   Ye, Jiaxin ^a   Ferro, Albert ^b   Xu, Biao ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; DOXORUBICIN; INTEGRIN LINKED KINASE; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CARDIOVASCULAR GENE THERAPY; CELL DEGENERATION; CELL INFILTRATION; CELL VACUOLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DRUG EFFICACY; ECHOCARDIOGRAPHY; GENE OVEREXPRESSION; HEART DILATATION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CELL; HEART PROTECTION; INFLAMMATORY INFILTRATE; MALE; MORTALITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; RAT; SURVIVAL RATE; TREATMENT RESPONSE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; DISEASE MODEL; DRUG EFFECT; GENE THERAPY; GENETICS; HEART; HEART VENTRICLE REMODELING; INFLAMMATION; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; TREATMENT OUTCOME;

RATTUS;

ANIMALS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; GENE THERAPY; HEART; INFLAMMATION; MORTALITY; MYOCYTES, CARDIAC; PROTEIN-SERINE-THREONINE KINASES; RATS; TREATMENT OUTCOME; VENTRICULAR REMODELING;

EID: 84856918850     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031279     Document Type: Article

References (36)

1. Kaye DM, Krum H, (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat Rev Drug Discov 6: 127-139.
2. Nagaya N, Kangawa K, Itoh T, Iwase T, Murakami S, et al. (2005) Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 112: 1128-1135.
3. Ishida M, Tomita S, Nakatani T, Fukuhara S, Hamamoto M, et al. (2004) Bone marrow mononuclear cell transplantation had beneficial effects on doxorubicin-induced cardiomyopathy. J Heart Lung Transplant 23: 436-445.
4. Suzuki K, Murtuza B, Suzuki N, Smolenski RT, Yacoub MH, (2001) Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure. Circulation 104: I213-217.
5. Komamura K, Tatsumi R, Miyazaki J, Matsumoto K, Yamato E, et al. (2004) Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle. Hypertension 44: 365-371.
6. Ambler GR, Johnston BM, Maxwell L, Gavin JB, Gluckman PD, (1993) Improvement of doxorubicin induced cardiomyopathy in rats treated with insulin-like growth factor I. Cardiovasc Res 27: 1368-1373.
7. Zhang J, Ding L, Zhao Y, Sun W, Chen B, et al. (2009) Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation 119: 1776-1784.
8. Bendig G, Grimmler M, Huttner IG, Wessels G, Dahme T, et al. (2006) Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev 20: 2361-2372.
9. Lu H, Fedak PW, Dai X, Du C, Zhou YQ, et al. (2006) Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation 114: 2271-2279.
10. Hannigan G, Troussard AA, Dedhar S, (2005) Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5: 51-63.
11. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, et al. (1996) Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379: 91-96.
12. White DE, Coutu P, Shi YF, Tardif JC, Nattel S, et al. (2006) Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev 20: 2355-2360.
13. Ding L, Dong L, Chen X, Zhang L, Xu X, et al. (2009) Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction. Circulation 120: 764-773.
14. Woo YJ, Panlilio CM, Cheng RK, Liao GP, Atluri P, et al. (2006) Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Circulation 114: I206-213.
15. Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F, et al. (2001) Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104: 1430-1435.
16. Wu S, Ko YS, Teng MS, Ko YL, Hsu LA, et al. (2002) Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol 34: 1595-1607.
17. Matoba S, Tatsumi T, Keira N, Kawahara A, Akashi K, et al. (1999) Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia/reoxygenation injury in cultured rat cardiac myocytes. Circulation 99: 817-822.
18. Wang L, Ma W, Markovich R, Chen JW, Wang PH, (1998) Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circ Res 83: 516-522.
19. Tsuneyoshi H, Nishina T, Nomoto T, Kanemitsu H, Kawakami R, et al. (2004) Atrial natriuretic peptide helps prevent late remodeling after left ventricular aneurysm repair. Circulation 110: II174-179.
20. Abbate A, Biondi-Zoccai GG, Bussani R, Dobrina A, Camilot D, et al. (2003) Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure. J Am Coll Cardiol 41: 753-760.
21. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K, (2000) Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667.
22. Yamabi H, Lu H, Dai X, Lu Y, Hannigan G, et al. (2006) Overexpression of integrin-linked kinase induces cardiac stem cell expansion. J Thorac Cardiovasc Surg 132: 1272-1279.
23. Sakai T, Li S, Docheva D, Grashoff C, Sakai K, et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev 17: 926-940.
24. Pasumarthi KB, Nakajima H, Nakajima HO, Soonpaa MH, Field LJ, (2005) Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res 96: 110-118.
25. Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D, (2004) Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-472.
26. Wong SC, Fukuchi M, Melnyk P, Rodger I, Giaid A, (1998) Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. Circulation 98: 100-103.
27. Bryant D, Becker L, Richardson J, Shelton J, Franco F, et al. (1998) Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 97: 1375-1381.
28. Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, et al. (2003) Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 107: 984-991.
29. Li L, Takemura G, Li Y, Miyata S, Esaki M, et al. (2007) Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy. Lab Invest 87: 440-455.
30. Lou H, Danelisen I, Singal PK, (2004) Cytokines are not upregulated in adriamycin-induced cardiomyopathy and heart failure. J Mol Cell Cardiol 36: 683-690.
31. Kalyanaraman B, Joseph J, Kalivendi S, Wang S, Konorev E, et al. (2002) Doxorubicin-induced apoptosis: implications in cardiotoxicity. Mol Cell Biochem 234-235: 119-124.
32. Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L, (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56: 185-229.
33. Singal PK, Iliskovic N, (1998) Doxorubicin-induced cardiomyopathy. N Engl J Med 339: 900-905.
34. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, et al. (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11: 376-381.
35. Klionsky DJ, Emr SD, (2000) Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721.
36. Martinet W, Knaapen MW, Kockx MM, De Meyer GR, (2007) Autophagy in cardiovascular disease. Trends Mol Med 13: 482-491.