Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction

Circulation

Volumn 120, Issue 9, 2009, Pages 764-773

  Ding, Liang ^b   Dong, Li ^b   Chen, Xin ^b   Zhang, Lujie ^b   Xu, Xiaoyu ^a   Ferro, Albert ^c   Xu, Biao ^b  

^a NANJING UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Angiogenesis; Apoptosis; Gene therapy; Myocardial infarction; Remodeling

Indexed keywords

ADENOVIRUS VECTOR; CYCLINE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; HISTONE H3; INTEGRIN LINKED KINASE; KI 67 ANTIGEN; BIOLOGICAL MARKER; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE THERAPY; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART VENTRICLE REMODELING; HEMODYNAMICS; IMMUNOFLUORESCENCE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ADENOVIRUS; ANIMAL; CELL DIVISION; CYTOLOGY; DISEASE MODEL; GENETICS; HEART FUNCTION TEST; HEART MUSCLE CELL; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL DIVISION; DISEASE MODELS, ANIMAL; GENE THERAPY; HEART FUNCTION TESTS; MALE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR REMODELING;

EID: 70349334413     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.870725     Document Type: Article

References (29)

1. Gheorghiade M, Bonow RO. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation. 1998;97:282-289. (Pubitemid 28067315)
2. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling - concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am. Coll. Cardiol. 2000;35:569-582. (Pubitemid 30167013)
3. Sutton MGSJ, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation. 2000; 101: 2981-2988. (Pubitemid 30415891)
4. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature. 1996;379:91-96. (Pubitemid 26008142)
5. Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer. 2005;5:51-63.
6. Bendig G, Grimmler M, Huttner IG, Wessels G, Dahme T, Just S, Trano N, Katus HA, Fishman MC, Rottbauer W. Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev. 2006;20:2361-2372.
7. Lu H, Fedak PWM, Dai X, Du C, Zhou YQ, Henkelman M, Mongroo PS, Lau A, Yamabi H, Hinek A, Husain M, Hannigan G, Coles JG. Integrinlinked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation. 2006;114: 2271-2279. (Pubitemid 44789501)
8. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13-22.
9. White DE, Coutu P, Shi YF, Tardif JC, Nattel S, St Arnaud R, Dedhar S, Muller WJ. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev. 2006; 20:2355-2360. (Pubitemid 44320384)
10. Lee SP, Youn SW, Cho HJ, Li L, Kim. TY, Yook HS, Chung JW, Hur J, Yoon CH, Park KW, Oh BH, Park YB, Kim. HS. Integrin-linked kinase, a hypoxia-responsive molecule, controls postnatal vasculogenesis by recruitment of endothelial progenitor cells to ischemic tissue. Circulation. 2006;114:150-159. (Pubitemid 44420747)
11. Pfeffer JM, Pfeffer MA, Fletcher PJ, Braunwald E. Progressive ventricular remodeling in rat with myocardial infarction. Am. J Physiol. 1991; 260:1406-1441.
12. Tan LB, Jalil JE, Pick R, Janicki JS, Weber KT. Cardiac myocyte necrosis induced by angiotensin II. Circ Res. 1991;69:1185-1195.
13. Sharov VG, Sabbah HN, Shimoyama H, Goussev AV, Lesch M, Goldstein S. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J Pathol. 1996;148:141-149. (Pubitemid 26019652)
14. Weber KT, Pick R, Silver MA, Moe GW, Janicki JS, Zucker IH. Fibrillar collagen and remodeling of dilated canine left ventricle. Circulation. 1990;82:1387-1401.
15. Dumasius V, Jameel M, Burhop J, Meng FJ, Welch LC, Mutlu GM, Factor P. In vivo timing of onset of transgene expression following adenoviral-mediated gene transfer. Virology. 2003;308:243-249. (Pubitemid 36434232)
16. Tsuneyoshi H, Nishina T, Nomoto T, Kanemitsu H, Kawakami R, Unimonh O, Nishimura K, Komeda M. Atrial natriuretic peptide helps prevent late remodeling after left ventricular aneurysm, repair. Circulation. 2004;110:II-174-II-179.
17. Gao F, Tao L, Yan W, Gao E, Liu HR, Lopez BL, Christopher TA, Ma X. Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged, reperfusion. Apoptosis. 2004;9:553-559. (Pubitemid 39158631)
18. Abbate A, Biondi-Zoccai GGL, Bussani R, Dobrina A, Camilot D, Feroce F, Rossiello R, Baldi F, Silvestři F, Biasucci LM, Baldi A. Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure. J Am Coll Cardiol. 2003;41:753-760.
19. Sam F, Sawyer DB, Chang DLF, Eberli FR, Ngoy S, Jain M, Amin J, Apstein CS, Colucci WS. Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart. Am. J Physiol. 2000;279:H422-H428. (Pubitemid 30616685)
20. Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten. RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol. 2004;24:8134-8144. (Pubitemid 39167462)
21. Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S. Regulation, of tumor angiogenesis by integrinlinked kinase (ILK). Cancer Cell. 2004;5:79-90. (Pubitemid 38121598)
22. Soonpaa MH, Field LJ. Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circ Res. 1998;83:15-26.
23. Yamabi H, Lu H, Da Xi, Lu Y, Hannigan G, Coles JG. Overexpression. of integrin-linked kinase induces cardiac stem cell expansion. J Thorac Cardiovasc Surg. 2006;132:1272-1279. (Pubitemid 44820228)
24. Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G, Braun A, Pfeifer A, Yurchenco PD, Fassler R. Integrin-linked kinase (ILK) is required, for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 2003;17:926-940. (Pubitemid 36397379)
25. Pasumarthi KBS, Nakajima H, Nakajima HO, Soonpaa MH, Field LJ. Targeted expression of cyclin d2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res. 2005;96:110-118. (Pubitemid 40095760)
26. Sun Y, Weber KT. Infarct scar: a dynamic tissue. Cardiovasc Res. 2000;46:250-256.
27. Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA. Role of integrin-linked kinase in regulating phosphorylation of akt and fibroblast survival in type I collagen matrices through α β1 integrin viability signaling pathway. J Biol Chem. 2005;280:26630-26639.
28. Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G, Braun A, Pfeifer A, Yurchenco PD, Fassler R. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 2003;17:926-940.
29. Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date M, Gu Y, Iwatate M, Li M, Wang L, Wilson JM Wang Y, Ross J Jr, Chien KR. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002;8:864-871.