Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors

Biochemistry

Volumn 51, Issue 1, 2012, Pages 43-51

  Vekhoff, Pierre ^a,b   Duca, Maria ^c   Guianvarc'h, Dominique ^d   Benhida, Rachid ^c   Arimondo, Paola B ^a,b  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS   (France)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR AGENTS; BASE PAIRS; CAMPTOTHECIN DERIVATIVES; CAMPTOTHECINS; COVALENT LINKAGE; DNA CLEAVAGE; DNA STRANDS; DNA TOPOLOGY; INHIBITION ACTIVITY; NUCLEOBASES; STRUCTURAL STUDIES; TOPOISOMERASES; TRIPLEX FORMATION; TRIPLEX-FORMING OLIGONUCLEOTIDES; WEAK BINDING;

BODY FLUIDS; OLIGONUCLEOTIDES;

DNA;

CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE 1B INHIBITOR; DNA TOPOISOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; DNA CLEAVAGE; DRUG TARGETING; ENZYME INHIBITOR COMPLEX; INTERCALATION COMPLEX; PRIORITY JOURNAL;

BASE PAIRING; BASE SEQUENCE; DEOXYRIBONUCLEASE I; DNA; DNA DAMAGE; DNA FOOTPRINTING; DNA TOPOISOMERASES, TYPE I; DNA-BINDING PROTEINS; GENE TARGETING; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; TOPOISOMERASE I INHIBITORS;

EID: 84856894764     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2012959     Document Type: Article

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