The Drosophila PGC-1α homolog spargel modulates the physiological effects of endurance exercise

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Tinkerhess, Martin J ^a   Healy, Lindsey ^a   Morgan, Matthew ^a   Sujkowski, Alyson ^a   Matthys, Erin ^a   Zheng, Li ^a   Wessells, Robert J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; DROSOPHILA PROTEIN; HEAT SHOCK PROTEIN; PGC PROTEIN, DROSOPHILA; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; BREATHING RATE; CONTROLLED STUDY; DROSOPHILA; ENDURANCE TRAINING; EXHAUSTION; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; HEART; HEART PACING; HEART PERFORMANCE; LOCOMOTION; LONGEVITY; MUSCLE TISSUE; NONHUMAN; PHENOTYPE; SEQUENCE HOMOLOGY; SPARGEL GENE; SURVIVAL RATE; ANIMAL; ENDURANCE; GENETICS; PHYSIOLOGY;

INVERTEBRATA; VERTEBRATA;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; HEAT-SHOCK PROTEINS; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; TRANSCRIPTION FACTORS;

EID: 84856879434     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031633     Document Type: Article

References (27)

1. Piazza N, Gosangi B, Devilla S, Arking R, Wessells R, (2009) Exercise-Training in Young Drosophila melanogaster Reduces Age-Related Decline in Mobility and Cardiac Performance. Plos One 4.
2. Goto M, Terada S, Kato M, Katoh M, Yokozeki T, et al. (2000) cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem Biophys Res Commun 274: 350-354.
3. Little JP, Safdar A, Bishop D, Tarnopolsky MA, Gibala MJ, (2011) An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1 alpha and activates mitochondrial biogenesis in human skeletal muscle. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 300: R1303-R1310.
4. Sutherland LN, Bomhof MR, Capozzi LC, Basaraba SAU, Wright DC, (2009) Exercise and adrenaline increase PGC-1 alpha mRNA expression in rat adipose tissue. Journal of Physiology-London 587: 1607-1617.
5. Winder WW, Taylor EB, Thomson DM, (2006) Role of AMP-activated protein kinase in the molecular adaptation to endurance exercise. Medicine and Science in Sports and Exercise 38: 1945-1949.
6. Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, et al. (2007) Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1 alpha expression. Journal of Biological Chemistry 282: 194-199.
7. Wu ZD, Puigserver P, Andersson U, Zhang CY, Adelmant G, et al. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124.
8. Scarpulla RC, (2008) Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator. In: Gibson GE, Ratan RR, Beal MF, editors. Mitochondria and Oxidative Stress in Neurodegenerative Disorders pp. 321-334.
9. Puigserver P, Wu ZD, Park CW, Graves R, Wright M, et al. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829-839.
10. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, et al. (2003) Acquirement of brown fat cell features by human white adipocytes. Journal of Biological Chemistry 278: 33370-33376.
11. Calvo JA, Daniels TG, Wang X, Paul A, Lin J, et al. (2008) Muscle-specific expression of PPAR gamma coactivator-1 alpha improves exercise performance and increases peak oxygen uptake. Journal of Applied Physiology 104: 1304-1312.
12. Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, et al. (2008) Paradoxical effects of increased expression of PGC-1 alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America 105: 19926-19931.
13. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, et al. (2005) PGC-1 alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis. Plos Biology 3: 672-687.
14. Tiefenbock SK, Baltzer C, Egli NA, Frei C, (2010) The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. Embo Journal 29: 171-183.
15. Rera M, Bahadorani S, Cho J, Koehler Christopher L, Ulgherait M, et al. (2011) Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog. Cell Metabolism 14: 623-634.
16. Holloszy JOea, (1976) Biochemical adaptations to endurance exercise in muscle. Annu Rev Physiol 38: 273-291.
17. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, et al. (2002) Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. Faseb Journal 16: 1879-1886.
18. Pilegaard H, Saltin B, Neufer PD, (2003) Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol 546: 851-858.
19. Lin JD, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, et al. (2004) Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1 alpha null mice. Cell 119: 121-+.
20. Holloszy JO, (1997) Mortality rate and longevity of food-restricted exercising male rats: A reevaluation. Journal of Applied Physiology 82: 399-403.
21. Holloszy JO, Smith EK, Vining M, Adams S, (1985) Effect of Voluntary Exercise on Longevity of Rats. Journal of Applied Physiology 59: 826-831.
22. Gargano JWea, (2005) Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Exp Gerontol 40: 386-395.
23. Davidson SR, Burnett M, Hoffman-Goetz L, (2006) Training effects in mice after long-term voluntary exercise. Medicine and Science in Sports and Exercise 38: 250-255.
24. Cornelissen VA, Fagard RH, (2005) Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension 46: 667-675.
25. Wessells RJ, Fitzgerald E, Cypser JR, Tatar M, Bodmer R, (2004) Insulin regulation of heart function in aging fruit flies. Nature Genetics 36: 1275-1281.
26. Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, et al. (2007) Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1 alpha muscle-specific knock-out animals. Journal of Biological Chemistry 282: 30014-30021.
27. Geng TY, Li P, Okutsu M, Yin XH, Kwek J, et al. (2010) PGC-1 alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. American Journal of Physiology-Cell Physiology 298: C572-C579.