Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in Δf508 cystic fibrosis transmembrane conductance regulator protein

Journal of Medicinal Chemistry

Volumn 55, Issue 3, 2012, Pages 1242-1251

  Knapp, John M ^a   Wood, Alex B ^a   Phuan, Puay Wah ^b   Lodewyk, Michael W ^a   Tantillo, Dean J ^a   Verkman, A S ^b   Kurth, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 METHOXYBENZOYL)PIPERAZIN 1 YL] 5,7 DIMETHYLQUINOLINE 3 CARBONITRILE; 2 [4 (3 METHOXYBENZOYL)PIPERAZIN 1 YL] 5,7 DIMETHYLQUINOLINE 3 CARBONITRILE; 2 [4 (4 METHOXYBENZOYL)PIPERAZIN 1 YL] 5,7 DIMETHYLQUINOLINE 3 CARBONITRILE; 5,7 DIMETHYL 2 (4 PICOLINOYLPIPERAZIN 1 YL)QUINOLINE 3 CARBONITRILE; AROMATIC AMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL] 2 METHOXYBENZAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL] 2,4 DIMETHOXYBENZAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL] 2,6 DIMETHOXYBENZAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL] 3,4 DIMETHOXYBENZAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL] 4 METHOXYBENZAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL] 5 METHOXYPICOLINAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL]BENZAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL]ISONICOTINAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL]NICOTINAMIDE; N [2 [(3 CYANO 5,7 DIMETHYLQUINOLIN 2 YL)AMINO]ETHYL]PICOLINAMIDE; N [3 (3 CYANO 5,7 DIMETHYLQUINOLIN 2 YLAMINO)PROPYL] 2 METHOXYBENZAMIDE; N [3 (3 CYANO 5,7 DIMETHYLQUINOLIN 2 YLAMINO)PROPYL] 3 METHOXYBENZAMIDE; N [3 (3 CYANO 5,7 DIMETHYLQUINOLIN 2 YLAMINO)PROPYL] 4 METHOXYBENZAMIDE; N [3 (3 CYANO 5,7 DIMETHYLQUINOLIN 2 YLAMINO)PROPYL]ISONICOTINAMIDE; N [3 (3 CYANO 5,7 DIMETHYLQUINOLIN 2 YLAMINO)PROPYL]NICOTINAMIDE; N [3 (3 CYANO 5,7 DIMETHYLQUINOLIN 2 YLAMINO)PROPYL]PICOLINAMIDE; QUINOLINE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENTIATION; DRUG SYNTHESIS; DRUG TARGETING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELLS, CULTURED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRILES; QUINOLINES; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856850146     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201372q     Document Type: Article

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