Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 15215-15226

  Pedemonte, Nicoletta ^a   Tomati, Valeria ^a,b   Sondo, Elvira ^a,b   Caci, Emanuela ^a   Millo, Enrico ^c,d   Armirotti, Andrea ^b   Damonte, Gianluca ^c,d   Zegarra Moran, Olga ^a   Galietta, Luis J V ^a  

^a G GASLINI INSTITUTE   (Italy)

^b CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d Centro di Eccellenza per la Ricerca Biomedica   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL ACTIVITY; CHLORIDE CHANNELS; CHRONIC TREATMENT; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; ENDOPLASMIC RETICULUM; FUNCTIONAL ASSAYS; SINGLE CHANNEL RECORDING;

CHLORINE COMPOUNDS;

DEFECTS;

AMINOARYLTHIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENZYME ACTIVITY; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RAT;

BIOLOGICAL TRANSPORT; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; ION CHANNEL GATING; MUTATION; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 79955368563     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.184267     Document Type: Article

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