Nanoparticle delivery systems formed using electrically sprayed Co-flowing excipients and active agent

Journal of Biomedical Nanotechnology

Volumn 7, Issue 6, 2011, Pages 782-793

  Bakhshi, Raheleh ^a   Ahmad, Zeeshan ^b   Soric, Mihaela ^a   Stride, Eleanor ^a   Edirisinghe, Mohan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Controlled release; Drug Delivery; Electrohydrodynamic; Insulin; Nanoparticles; Poly(lactic coglycolic acid) (PLGA); Polymer

Indexed keywords

ACTIVE AGENTS; APPLIED VOLTAGES; BIODEGRADABLE NANOPARTICLE; BURST RELEASE; CONTROL VARIABLE; CONTROLLED RELEASE; DELIVERY SYSTEMS; DRUG RELEASE; ENCAPSULATION EFFICIENCY; HIGH PRODUCTION RATE; HIGH YIELD; IN-VITRO; INSULIN RELEASE; PARTICLE SHAPE; PLGA NANOPARTICLES; POLY(LACTIC-CO-GLYCOLIC ACID); POLY(LACTIC-COGLYCOLIC ACID) (PLGA); POLYMER CONCENTRATIONS; POLYMERIC NANOPARTICLES; SINGLE-STEP; SUSTAINED RELEASE;

ATOMIC FORCE MICROSCOPY; DRUG PRODUCTS; ELECTROHYDRODYNAMICS; ENCAPSULATION; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; POLYMERS;

INSULIN;

INSULIN; NANOPARTICLE; POLYLACTIC ACID; POLYMER;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIODEGRADABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ELECTRIC POTENTIAL; ELECTRICITY; ELECTROHYDRODYNAMICS; ELECTRON; ENCAPSULATION; ENVIRONMENTAL TEMPERATURE; FOURIER TRANSFORM MASS SPECTROMETRY; HYDRODYNAMICS; INFRARED SPECTROMETRY; INSULIN RELEASE; MOLECULAR WEIGHT; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; THERMOGRAPHY;

DELAYED-ACTION PREPARATIONS; ELECTROCHEMICAL TECHNIQUES; EXCIPIENTS; GLYCEROL; INSULIN; LACTIC ACID; MICROSCOPY, ATOMIC FORCE; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84856841134     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2011.1353     Document Type: Article

References (63)

1. A. Soares, R. A. Carvalho, and F. Veiga, Oral administration of peptides and proteins: Nanoparticles and cyclodextrins as biocompatible delivery systems. Nanomedicine 2, 183 (2007).
2. G. Deibler, L. Boyd, and M. Kies, Enzymatic and nonenzymatic degradation of myelin basic protein. Neurochem. Res. 9, 1371 (1984).
3. A. Jang and M. Lee, Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates. Meat Sci. 69, 653 (2005).
4. P. C. Naha, V. Kanchan, and A. K. Panda, Evaluation of parenteral depot insulin formulation using PLGA and PLA microparticles. J. Biomater. Appl. 24, 309 (2009).
5. S. Cohen, T. Yoshioka, M. Lucarelli, L. H. Hwang, and R. Langer, Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8, 713 (1991).
6. P. Kocbek, N. Obermajer, M. Cegnar, J. Kos, and J. Kristl, Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody. J. Control. Release 120, 18 (2007).
7. K. S. Oh, J. Y. Song, S. H. Cho, B. S. Lee, S. Y. Kim, K. Kim, H. Jeon, I. C. Kwon, and S. H. Yuk, Paclitaxel-loaded Pluronic nanoparticles formed by a temperature-induced phase transition for cancer therapy. J. Control. Release 148, 344 (2010).
8. K. H. Singh and U. A. Shinde, Development and evaluation of novel polymeric nanoparticles of brimonidine tartrate. Current Drug Delivery 7, 244 (2010).
9. S. S. Bhattacharyya, S. Paul, and A. R. Khuda-Bukhsh, Encapsulated plant extract (Gelsemium sempervirens) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro. Exp. Biol. Med. 235, 678 (2010).
10. C. Damgé, C. Michel, M. Aprahamian, P. Couvreur, and P. Devissaguet, Nanocapsules as carriers for oral peptide delivery. J. Control. Release 13, 233 (1990).
11. D. Samuel, D. Bharali, and S. A. Mousa, The role of nanotechnology in diabetes treatment: Current and future perspectives. Int. J. Nanotechnol. 8, 53 (2011).
12. M. Stefani, J. Coudane, and M. Vert, In vitro ageing and degradation of PEG-PLA diblock copolymer-based nanoparticles. Polym. Degrad. Stabil. 91, 2554 (2006).
13. H. Sah, R. Toddywala, and Y. Chien, The influence of biodegradable microcapsule formulations on the controlled release of a protein. J. Control. Release 30, 201 (1994).
14. K. Shi, F. Cui, H. Yamamoto, and Y. Kawashima, Optimized preparation of insulin-lauryl sulfate complex loaded poly (lactide-co-glycolide) nanoparticles using response surface methodology. Pharmazie 63, 721 (2008).
15. K. Shi, F. Cui, H. Yamamoto, and Y. Kawashima, Investigation of drug loading and in vitro release mechanisms of insulin-lauryl sulfate complex loaded PLGA nanoparticles. Pharmazie 63, 866 (2008).
16. K. Shi, F. Cui, H. Yamamoto, and Y. Kawashima, Optimized formulation of high-payload PLGA nanoparticles containing insulin-lauryl sulfate complex. Drug Dev. Ind. Pharm. 35, 177 (2009).
17. S. Sun, N. Liang, H. Piao, H. Yamamoto, Y. Kawashima, and F. Cui, Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles. formulation, characterization and in vivo evaluation. J. Microencapsul. 27, 471 (2010).
18. F. Cui, K. Shi, L. Zhang, A. Tao, and Y. Kawashima, Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation. J. Control. Release 28, 242 (2006).
19. J. M. Barichello, M. Morishita, K. Takayama, and T. Nagai, Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Dev. Ind. Pharm. 25, 471 (1999).
20. C. E. Mora-Huertas, H. Fessi, and A. Elaissari, Polymer-based nanocapsules for drug delivery. Int. J. Pharm. 385, 113 (2010).
21. A. Mukerjee and V. Pruthi, Oral insulin delivery by polymeric nanospheres. J. Biomed. Nanotechnol. 3, 68 (2007).
22. P. S. Kumar, S. Ramakrishna, T. R. Saini, and P. V. Diwan, Influence of microencapsulation method and peptide loading on formulation of poly(lactide-co-glycolide) insulin nanoparticles. Pharmazie 61, 613 (2006).
23. S. P. Schwendeman, Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 19, 73 (2002).
24. C. M. Silva, A. J. Ribeiro, I. Figueiredo, A. Gonçalves, and F. Veiga, Alginate microspheres prepared by internal gelation: Development and effect on insulin stability. Int. J. Pharmaceut. 311, 1 (2006).
25. U. Farook, M. J. Edirisinghe, E. Stride, and P. Colombo, Novel co-axial electrohydrodynamic in-situ preparation of liquid-filled polymer-shell microspheres for biomedical applications. J. Microencapsul. 25, 241 (2008).
26. J. Xie, L. K. Lim, Y. Phua, J. Hua, and C. H. Wang. Electrohydrodynamic atomization for biodegradable polymeric particle production. J. Colloid Interf. Sci. 302, 103 (2006).
27. J. Xie, J. C. Marijnissen, and C. H. Wang, Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. Biomaterials 27, 3321 (2006).
28. Z. Ahmad, H. B. Zhang, U. Farook, M. Edirisinghe, E. Stride, and P. Colombo, Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow. J.R.Soc. Interface 5, 1255 (2008).
29. M. Enayati, Z. Ahmad, E. Stride, and M. Edirisinghe, One-step electrohydrodynamic production of drug-loaded micro- and nanoparticles. J.R.Soc. Interface 7, 667 (2010).
30. M. Enayati, M.-w. Chang, F. Bragman, M. Edirisinghe, and E. Stride, Electrohydrodynamic preparation of particles, capsules and bubbles for biomedical engineering applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects 382, 154 (2011).
31. M. Cloupeau and B. Prunet-Foch, Electrostatic spraying of liquids: Main functioning modes. J. Electrostat. 25, 165 (1990).
32. L. Mu, S. S. Feng, A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. J. Control. Release 86, 33 (2003).
33. A. R. Ahmed, A. Dashevsky, and R. Bodmeier, Reduced burst effect in drug release with solvent-treated microparticles prepared by the solvent evaporation method. Proc. Int. Symp. Control. Release Bioact. Mater. 27, 297 (2000).
34. A. Jaworek and A. Krupa, Classification of the modes of EHD spraying. J. Aerosol Sci. 30, 975 (1999).
35. P. A. Hartman, D. J. Brunner, D. M. A. Camelot, J. C. M. Marijnissen, and B. Scarlett, Jet break-up in electrohydrodynamic atomization in the cone-jet mode. J. Aerosol Sci. 31, 65 (2000).
36. Y. Wu and R. L. Clark, Electrohydrodynamic atomization: A versatile process for preparing materials for biomedical applications. J. Biomater. Sci. Polym. Ed. 19, 573 (2008).
37. M. Enayati, Z. Ahmad, E. Stride, and M. Edirisinghe, Preparation of polymeric carriers for drug delivery with different shape and size using an electric jet. Curr. Pharm. Biotechno. 10, 600 (2009).
38. Y. Yeo and K. N. Park, Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch. Pharm. Res. 27, 1 (2004).
39. M. Jelvehgari, H. Valizadehl, M. Rezapour, and A. Nokhodchi, Control of encapsulation efficiency in polymeric microparticle system of tolmetin. Pharm. Dev. Technol. 15, 71 (2010).
40. M. T. Peracchia, R. Gref, Y. Minamitake, A. Domb, N. Lotan, and R. Langer, PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics. J. Control. Release 46, 223 (1997).
41. S. K. Vakkalanka, C. S. Brazel, and N. A. Peppas, Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. J. Biomater. Sci. Polym. Ed. 8, 119 (1996).
42. M. Chang, E. Stride, and M. Edirisinghe, Controlling the thickness of hollow polymeric microspheres prepared by electrohydrodynamic atomization. J. R. Soc. Interface 7, 451 (2010).
43. R. Bocanegra, D. Galan, M. Marquez, I. G. Loscertales, and A. Barrero, Multiple electrosprays emitted from an array of holes. J. Aerosol Sci. 36, 1387 (2005).
44. T. Gorner, R. Gref, D. Michenot, F. Sommer, M. Tran, and E. Dellacherie, Lidocaine-loaded biodegradable nanospheres. Optimization of the drug incorporation into the polymer matrix. J. Control. Release 57, 259 (1999).
45. S. Jayasinghe and M. Edirisinghe, Effect of viscosity on the size of relics produced by electrostatic atomization. J. Aerosol Sci. 33, 1379 (2002).
46. S. K. Sahoo, Polymeric nanoparticles for cancer therapy. J. Drug Target. 16, 108 (2008).
47. M. Dunne, I. Corrigan, and Z. Ramtoola, Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. Biomaterials 21, 1659 (2000).
48. I. Grizzi, H. Garreau, S. Li, and M. Vert. Hydrolytic degradation of devices based on poly(DL-lactic acid) size-dependence. Biomaterials 16, 305 (1995).
49. M. S. Muthu, Nanoparticles based on PLGA and its co-polymer: An overview. Asian Journal of Pharmaceutics 3, 266 (2009).
50. M. Li, W. Lu, J. Wang, X. Zhang, H. Zhang, X. Wang, C. Wu, and O. Zhang, Preparation and characterization of insulin nanoparticles employing chitosan and poly(methylmethacrylate/methylmethacrylic acid) copolymer. J. Nanosci. Nanotechnol. 6, 2874 (2006).
51. N. Dwivedi, M. A. Arunagirinathan, S. Sharma, and J. Bellare. Silica-coated liposomes for insulin delivery. J. Nanomater. 10, 652048 (2010).
52. T. Estey, J. Kang, S. P. Schwendeman, and J. F. Carpenter, BSA degradation under acidic conditions: A model for protein instability during release from PLGA delivery systems. J. Pharm. Sci. 95, 1626 (2006).
53. Y. Yamaguchi, M. Takenaga, A. Kitagawa, Y. Ogawa, Y. Mizushima, and R. Igarashi, Insulin-loaded biodegradable PLGA microcapsules: Initial burst release controlled by hydrophilic additives. J. Control. Release 81, 235 (2002).
54. B. Ru, S. Wei, W. Qun, and Z. Na, Solid lipid nanoparticles as insulin inhalation carriers for enhanced pulmonary delivery. J. Biomed. Nanotechnol. 5, 84 (2009).
55. M. Takenaga, Y. Yamaguchi, A. Kitagawa, Y. Ogawa, S. Kawai, and Y. Mizushima. Optimum formulation for sustained-release insulin. Int. J. Pharmaceut. 271, 85 (2004).
56. R. C. Mehta, B. C. Thanoo, and P. P. Deluca, Peptide containing microspheres from low molecular weight and hydrophilic poly(d,l-lactide-co- glycolide). J. Control. Release 41, 249 (1996).
57. R. Bodmeier and J. W. Mcginity, Solvent selection in the preparation of poly(Dl-Lactide) microspheres prepared by the solvent evaporation method. Int. J. Pharmaceut. 43, 179 (1988).
58. N. Csaba, L. González, A. Sánchez, and M. J. Alonso, Design and characterisation of new nanoparticulate polymer blends for drug delivery. J. Biomater. Sci. Polym. Ed. 15, 1137 (2004).
59. S. Davaran, M. R. Rashidi, B. Pourabbas, M. Dadashzadeh, and N. M. Haghshenas, Adriamycin release from poly(lactide-co-glycolide)-polyethylene glycol nanoparticles: Synthesis, and in vitro characterization. Int. J. Nanomed. 1, 535 (2006).
60. I. Bala, V. Bhardwaj, S. Hariharan, S. V. Kharade, N. Roy, and M. N. V. R. Kumar, Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration. J. Drug Target 14, 27 (2006).
61. Y. Dong and S. Feng, Poly(d,l-lactide-co-glycolide)/montmorillonite nanoparticles for oral delivery of anticancer drugs. Biomaterials 26, 6068 (2005).
62. C. Ramkissoon-Ganorkar, F. Liu, M. Baudys, and S. W. Kim, Modulating insulin-release profile from pH/thermosensitive polymeric beads through polymer molecular weight. J. Control. Release 59, 287 (1999).
63. N. Kalaji, N. Sheibat-Othman, H. Saadaoui, A. Elaisari, and H. Fessi, Colloidal and physicochemical characterization of protein containing poly(lactide-co-glycolide) (PLGA) microspheres before and after drying. E-polymers 10, 1 (2009).