Lidocaine-loaded biodegradable nanospheres. I. Optimization of the drug incorporation into the polymer matrix

Journal of Controlled Release

Volumn 57, Issue 3, 1999, Pages 259-268

  Gorner T ^a   Gref, R ^a   Michenot, D ^a   Sommer, F ^b   Tran, M N ^c   Dellacherie, E ^a  

^a LAB DE CHIM PHYS MACROMOLECULAIRE   (France)

^b Biophy Research   (France)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

Controlled release; Encapsulation; Lidocaine; Nanoparticles; Poly(D,L lactic acid)

Indexed keywords

DRUG CARRIER; LIDOCAINE; LOCAL ANESTHETIC AGENT; NANOPARTICLE; POLYLACTIC ACID; POLYMER;

ARTICLE; DRUG RELEASE; ENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; REPRODUCIBILITY;

ANESTHETICS, LOCAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; DRUG DELIVERY SYSTEMS; KINETICS; LACTIC ACID; LIDOCAINE; MICROSPHERES; MOLECULAR WEIGHT; PARTICLE SIZE; POLYMERS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; SURFACE PROPERTIES;

EID: 0041949915     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00121-7     Document Type: Article

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