메뉴 건너뛰기




Volumn 8, Issue 1-2, 2011, Pages 53-65

The role of nanotechnology in diabetes treatment: Current and future perspectives

Author keywords

Diabetes; Glucose sensors; Nanoparticles; Nanotechnology; Oral insulin

Indexed keywords

ARTIFICIAL ORGANS; DISEASES; GLUCOSE; GLUCOSE SENSORS; INSULIN; MEDICAL PROBLEMS; NANOPARTICLES; NANOTECHNOLOGY;

EID: 78649694997     PISSN: 14757435     EISSN: None     Source Type: Journal    
DOI: 10.1504/IJNT.2011.037170     Document Type: Article
Times cited : (14)

References (54)
  • 1
    • 0003770851 scopus 로고    scopus 로고
    • American Diabetes Association, obtained through the internet, [Accessed 8/15/2009]
    • American Diabetes Association (2009) Diabetes Statistics, obtained through the internet: http://www.diabetes.org/diabetes-statistics.jsp [Accessed 8/15/2009].
    • (2009) Diabetes Statistics
  • 2
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. (2004) 'Global prevalence of diabetes: estimates for the year 2000 and projections for 2030', Diabetes Care, Vol. 27, No. 5, pp.1047-1053.
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 3
    • 77955463958 scopus 로고    scopus 로고
    • American Diabetes Association, obtained through the internet, [Accessed 8/15/2009]
    • American Diabetes Association (2009) Complications of Diabetes in the United States, obtained through the internet: http://www.diabetes.org [Accessed 8/15/2009].
    • (2009) Complications of Diabetes in the United States
  • 5
    • 60849114994 scopus 로고    scopus 로고
    • Nanomedicine and its potential in diabetes research and practice
    • Pickup, J.C., Zhi, Z.L., Khan, F., Saxl, T. and Birch, D.J. (2008) 'Nanomedicine and its potential in diabetes research and practice', Diabetes Metab. Res. Rev., Vol. 24, No. 8, pp.604-610.
    • (2008) Diabetes Metab. Res. Rev. , vol.24 , Issue.8 , pp. 604-610
    • Pickup, J.C.1    Zhi, Z.L.2    Khan, F.3    Saxl, T.4    Birch, D.J.5
  • 6
    • 33947225700 scopus 로고    scopus 로고
    • The present and future of nanotechnology in human health care
    • Sahoo, S.K., Parveen, S. and Panda, J.J. (2007) 'The present and future of nanotechnology in human health care', Nanomedicine, Vol. 3, No. 1, pp.20-31.
    • (2007) Nanomedicine , vol.3 , Issue.1 , pp. 20-31
    • Sahoo, S.K.1    Parveen, S.2    Panda, J.J.3
  • 7
    • 31344445440 scopus 로고    scopus 로고
    • What is nanomedicine?
    • Freitas Jr., R.A. (2005) 'What is nanomedicine?', Nanomedicine, Vol. 1, No. 1, pp.2-9.
    • (2005) Nanomedicine , vol.1 , Issue.1 , pp. 2-9
    • Freitas Jr., R.A.1
  • 9
    • 63149173251 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2009
    • American Diabetes Associaton
    • American Diabetes Associaton (2009) 'Standards of medical care in diabetes-2009', Diabetes Care, Vol. 32, Suppl. 1, No. S13-61.
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 1
  • 10
    • 78649712561 scopus 로고    scopus 로고
    • American Diabetes Association, obtained through the internet, [Accessed 8/15/2009]
    • American Diabetes Association (2009) Diabetes Research Milestones, obtained through the internet: http://www.diabetes.org/diabetes-research/ diabetes-research-milestones.jsp [Accessed 8/15/2009].
    • (2009) Diabetes Research Milestones
  • 11
    • 0015372980 scopus 로고
    • Diabetes before and after insulin
    • Allan, F.N. (1972) 'Diabetes before and after insulin', Med. Hist., Vol. 16, No. 3, pp.266-273.
    • (1972) Med. Hist. , vol.16 , Issue.3 , pp. 266-273
    • Allan, F.N.1
  • 12
    • 41449088562 scopus 로고    scopus 로고
    • 2008 resource guide. Insulin delivery. Syringes..pumps..jet injectors..pens..infusers⋯they all do the same thing: Deliver insulin through the outermost layer of skin and into fatty tissue so it can be used by the body
    • American Diabetes Association
    • American Diabetes Association (2008) '2008 resource guide. Insulin delivery. Syringes..pumps..jet injectors..pens..infusers⋯they all do the same thing: deliver insulin through the outermost layer of skin and into fatty tissue so it can be used by the body', Diabetes Forecast, Vol. 61, No. 1, pp.RG17-29.
    • (2008) Diabetes Forecast , vol.61 , Issue.1
  • 13
    • 50049099939 scopus 로고    scopus 로고
    • Initiating insulin therapy in type 2 diabetes: Benefits of insulin analogs and insulin pens
    • Brunton, S. (2008) 'Initiating insulin therapy in type 2 diabetes: benefits of insulin analogs and insulin pens', Diabetes Technol. Ther., Vol. 10, No. 4, pp.247-256.
    • (2008) Diabetes Technol. Ther. , vol.10 , Issue.4 , pp. 247-256
    • Brunton, S.1
  • 14
    • 33644961570 scopus 로고    scopus 로고
    • FlexPen: Addressing issues of confidence and convenience in insulin delivery
    • Korytkowski, M., Niskanen, L. and Asakura, T. (2005) 'FlexPen: addressing issues of confidence and convenience in insulin delivery', Clin. Ther., Vol. 27, Suppl. B, No. S89-S100.
    • (2005) Clin. Ther. , vol.27 , Issue.SUPPL. B
    • Korytkowski, M.1    Niskanen, L.2    Asakura, T.3
  • 15
    • 78649717674 scopus 로고    scopus 로고
    • American Diabetes Association, obtained through the internet, [Accessed 8/17/2009]
    • American Diabetes Association (2009) Insulin Pumps, obtained through the internet: http://www.diabetes.org/type-1-diabetes/insulin-pumps.jsp [Accessed 8/17/2009].
    • (2009) Insulin Pumps
  • 16
    • 0037160919 scopus 로고    scopus 로고
    • Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: Meta-analysis of randomised controlled trials
    • Pickup, J., Mattock, M. and Kerry, S. (2002) 'Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: meta-analysis of randomised controlled trials', BMJ, Vol. 324, No. 7339, pp.705.
    • (2002) BMJ , vol.324 , Issue.7339 , pp. 705
    • Pickup, J.1    Mattock, M.2    Kerry, S.3
  • 17
    • 49649112407 scopus 로고    scopus 로고
    • Severe hypoglycaemia and glycaemic control in Type 1 diabetes: Meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion
    • Pickup, J.C. and Sutton, A.J. (2008) 'Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion', Diabet. Med., Vol. 25, No. 7, pp.765-774.
    • (2008) Diabet. Med. , vol.25 , Issue.7 , pp. 765-774
    • Pickup, J.C.1    Sutton, A.J.2
  • 18
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan, D.M., Buse, J.B., Davidson, M.B., Ferrannini, E., Holman, R.R., Sherwin, R. and Zinman, B. (2009) 'Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes', Diabetes Care, Vol. 32, No. 1, pp.193-203.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 19
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group (1998) 'Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)', Lancet, Vol. 352, No. 9131, pp.837-853.
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 20
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo, Y., Kishikawa, H., Araki, E., Miyata, T., Isami, S., Motoyoshi, S., Kojima, Y., Furuyoshi, N. and Shichiri, M. (1995) 'Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study', Diabetes Res. Clin. Pract., Vol. 28, No. 2, pp.103-117.
    • (1995) Diabetes Res. Clin. Pract. , vol.28 , Issue.2 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3    Miyata, T.4    Isami, S.5    Motoyoshi, S.6    Kojima, Y.7    Furuyoshi, N.8    Shichiri, M.9
  • 21
    • 0036736185 scopus 로고    scopus 로고
    • When oral agents fail: Practical barriers to starting insulin
    • Korytkowski, M. (2002) 'When oral agents fail: practical barriers to starting insulin', Int. J. Obes. Relat. Metab. Disord., Vol. 26, Suppl. 3, pp.18-24.
    • (2002) Int. J. Obes. Relat. Metab. Disord. , vol.26 , Issue.SUPPL. 3 , pp. 18-24
    • Korytkowski, M.1
  • 22
    • 33750177969 scopus 로고    scopus 로고
    • Nanoscale analysis of protein and peptide absorption: Insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles
    • Peppas, N.A. and Kavimandan, N.J. (2006) 'Nanoscale analysis of protein and peptide absorption: insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles', Eur. J. Pharm. Sci., Vol. 29, Nos. 3-4, pp.183-197.
    • (2006) Eur. J. Pharm. Sci. , vol.29 , Issue.3-4 , pp. 183-197
    • Peppas, N.A.1    Kavimandan, N.J.2
  • 23
    • 39049124118 scopus 로고    scopus 로고
    • Nanoparticle strategies for the oral delivery of insulin
    • Damge, C., Reis, C.P. and Maincent, P. (2008) 'Nanoparticle strategies for the oral delivery of insulin', Expert Opin. Drug. Deliv., Vol. 5, No. 1, pp.45-68.
    • (2008) Expert Opin. Drug. Deliv. , vol.5 , Issue.1 , pp. 45-68
    • Damge, C.1    Reis, C.P.2    Maincent, P.3
  • 24
    • 36248965689 scopus 로고    scopus 로고
    • Current challenges in non-invasive insulin delivery systems: A comparative review
    • Khafagy el, S., Morishita, M., Onuki, Y. and Takayama, K. (2007) 'Current challenges in non-invasive insulin delivery systems: a comparative review', Adv. Drug Delivery Rev., Vol. 59, No. 15, pp.1521-1546.
    • (2007) Adv. Drug Delivery Rev. , vol.59 , Issue.15 , pp. 1521-1546
    • Khafagy, El.S.1    Morishita, M.2    Onuki, Y.3    Takayama, K.4
  • 25
    • 47049095564 scopus 로고    scopus 로고
    • Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation
    • Woitiski, C.B., Carvalho, R.A., Ribeiro, A.J., Neufeld, R.J. and Veiga, F. (2008) 'Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation', BioDrugs, Vol. 22, No. 4, pp.223-237.
    • (2008) BioDrugs , vol.22 , Issue.4 , pp. 223-237
    • Woitiski, C.B.1    Carvalho, R.A.2    Ribeiro, A.J.3    Neufeld, R.J.4    Veiga, F.5
  • 27
    • 0023856501 scopus 로고
    • New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier
    • Damge, C., Michel, C., Aprahamian, M. and Couvreur, P. (1988) 'New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier', Diabetes, Vol. 37, No. 2, pp.246-251.
    • (1988) Diabetes , vol.37 , Issue.2 , pp. 246-251
    • Damge, C.1    Michel, C.2    Aprahamian, M.3    Couvreur, P.4
  • 28
    • 33846543799 scopus 로고    scopus 로고
    • Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats
    • Damge, C., Maincent, P. and Ubrich, N. (2007) 'Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats', J. Control Release, Vol. 117, No. 2, pp.163-170.
    • (2007) J. Control Release , vol.117 , Issue.2 , pp. 163-170
    • Damge, C.1    Maincent, P.2    Ubrich, N.3
  • 29
    • 0037027876 scopus 로고    scopus 로고
    • Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    • Pan, Y., Li, Y.J., Zhao, H.Y., Zheng, J.M., Xu, H., Wei, G., Hao, J.S. and Cui, F.D. (2002) 'Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo', Int. J. Pharm., Vol. 249, Nos. 1-2, pp.139-147.
    • (2002) Int. J. Pharm. , vol.249 , Issue.1-2 , pp. 139-147
    • Pan, Y.1    Li, Y.J.2    Zhao, H.Y.3    Zheng, J.M.4    Xu, H.5    Wei, G.6    Hao, J.S.7    Cui, F.D.8
  • 30
    • 60849101842 scopus 로고    scopus 로고
    • Chitosan and its use in design of insulin delivery system
    • Wong, T.W. (2009) 'Chitosan and its use in design of insulin delivery system', Recent. Pat. Drug Deliv. Formul., Vol. 3, No. 1, pp.8-25.
    • (2009) Recent. Pat. Drug Deliv. Formul. , vol.3 , Issue.1 , pp. 8-25
    • Wong, T.W.1
  • 31
    • 34250835820 scopus 로고    scopus 로고
    • Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin
    • Bhumkar, D.R., Joshi, H.M., Sastry, M. and Pokharkar, V.B. (2007) 'Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin', Pharm. Res., Vol. 24, No. 8, pp.1415-1426.
    • (2007) Pharm. Res. , vol.24 , Issue.8 , pp. 1415-1426
    • Bhumkar, D.R.1    Joshi, H.M.2    Sastry, M.3    Pokharkar, V.B.4
  • 32
    • 35848959714 scopus 로고    scopus 로고
    • Alginate/chitosan nanoparticles are effective for oral insulin delivery
    • Sarmento, B., Ribeiro, A., Veiga, F., Sampaio, P., Neufeld, R. and Ferreira, D. (2007) 'Alginate/chitosan nanoparticles are effective for oral insulin delivery', Pharm. Res., Vol. 24, No. 12, pp.2198-2206.
    • (2007) Pharm. Res. , vol.24 , Issue.12 , pp. 2198-2206
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3    Sampaio, P.4    Neufeld, R.5    Ferreira, D.6
  • 33
    • 70349303363 scopus 로고    scopus 로고
    • Formulation and characterization of an oily-based system for oral delivery of insulin
    • Elsayed, A., Remawi, M.A., Qinna, N., Farouk, A. and Badwan, A. (2009) 'Formulation and characterization of an oily-based system for oral delivery of insulin', Eur. J. Pharm. Biopharm, Vol. 73, No. 2, pp.269-279.
    • (2009) Eur. J. Pharm. Biopharm , vol.73 , Issue.2 , pp. 269-279
    • Elsayed, A.1    Remawi, M.A.2    Qinna, N.3    Farouk, A.4    Badwan, A.5
  • 34
    • 68549122512 scopus 로고    scopus 로고
    • Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
    • Yin, L., Ding, J., He, C., Cui, L., Tang, C. and Yin, C. (2009) 'Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery', Biomaterials, Vol. 30, No. 29, pp.5691-5700.
    • (2009) Biomaterials , vol.30 , Issue.29 , pp. 5691-5700
    • Yin, L.1    Ding, J.2    He, C.3    Cui, L.4    Tang, C.5    Yin, C.6
  • 35
    • 68949159829 scopus 로고    scopus 로고
    • Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors
    • Verspohl, E.J. (2009) 'Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors', Pharmacol Ther., Vol. 124, No. 1, pp.113-138.
    • (2009) Pharmacol Ther. , vol.124 , Issue.1 , pp. 113-138
    • Verspohl, E.J.1
  • 36
    • 62449126447 scopus 로고    scopus 로고
    • Glucose sensors: A review of current and emerging technology
    • Oliver, N.S., Toumazou, C., Cass, A.E. and Johnston, D.G. (2009) 'Glucose sensors: a review of current and emerging technology', Diabet. Med., Vol. 26, No. 3, pp.197-210.
    • (2009) Diabet. Med. , vol.26 , Issue.3 , pp. 197-210
    • Oliver, N.S.1    Toumazou, C.2    Cass, A.E.3    Johnston, D.G.4
  • 37
    • 70349235912 scopus 로고    scopus 로고
    • Continuous glucose sensing: Future technology developments
    • Brauker, J. (2009) 'Continuous glucose sensing: future technology developments', Diabetes Technol. Ther., Vol. 11, Suppl. 1, pp.25-36.
    • (2009) Diabetes Technol. Ther. , vol.11 , Issue.SUPPL. 1 , pp. 25-36
    • Brauker, J.1
  • 38
    • 27644556801 scopus 로고    scopus 로고
    • A review of continuous glucose monitoring technology
    • Klonoff, D.C. (2005) 'A review of continuous glucose monitoring technology', Diabetes Technol. Ther., Vol. 7, No. 5, pp.770-775.
    • (2005) Diabetes Technol. Ther. , vol.7 , Issue.5 , pp. 770-775
    • Klonoff, D.C.1
  • 39
    • 70349234391 scopus 로고    scopus 로고
    • The integrated MiniMed Paradigm REAL-Time insulin pump and glucose monitoring system: Implications for improved patient outcomes
    • Mastrototaro, J. and Lee, S. (2009) 'The integrated MiniMed Paradigm REAL-Time insulin pump and glucose monitoring system: implications for improved patient outcomes', Diabetes Technol. Ther., Vol. 11, Suppl 1, pp.37-43.
    • (2009) Diabetes Technol. Ther. , vol.11 , Issue.SUPPL. 1 , pp. 37-43
    • Mastrototaro, J.1    Lee, S.2
  • 40
    • 67349210316 scopus 로고    scopus 로고
    • Fluorescence lifetime spectroscopy and imaging of nano-engineered glucose sensor microcapsules based on glucose/galactose-binding protein
    • Saxl, T., Khan, F., Matthews, D.R., Zhi, Z.L., Rolinski, O., Ameer-Beg, S. and Pickup, J. (2009) 'Fluorescence lifetime spectroscopy and imaging of nano-engineered glucose sensor microcapsules based on glucose/galactose-binding protein', Biosens. Bioelectron., Vol. 24, No. 11, pp.3229-3234.
    • (2009) Biosens. Bioelectron. , vol.24 , Issue.11 , pp. 3229-3234
    • Saxl, T.1    Khan, F.2    Matthews, D.R.3    Zhi, Z.L.4    Rolinski, O.5    Ameer-Beg, S.6    Pickup, J.7
  • 41
    • 33645733054 scopus 로고    scopus 로고
    • Non-mediated glucose biosensing using nanostructured TiO2
    • Rankin, J., Byrne, T. and McAdams, E. (2005) 'Non-mediated glucose biosensing using nanostructured TiO2', Stud. Health Technol. Inform., Vol. 117, pp.207-212.
    • (2005) Stud. Health Technol. Inform. , vol.117 , pp. 207-212
    • Rankin, J.1    Byrne, T.2    McAdams, E.3
  • 42
    • 54249169589 scopus 로고    scopus 로고
    • Nanometal-decorated exfoliated graphite nanoplatelet based glucose biosensors with high sensitivity and fast response
    • Lu, J., Do, I., Drzal, L.T., Worden, R.M. and Lee, I. (2008) 'Nanometal-decorated exfoliated graphite nanoplatelet based glucose biosensors with high sensitivity and fast response', ACS Nano, Vol. 2, No. 9, pp.1825-32.
    • (2008) ACS Nano , vol.2 , Issue.9 , pp. 1825-1832
    • Lu, J.1    Do, I.2    Drzal, L.T.3    Worden, R.M.4    Lee, I.5
  • 43
    • 67349276118 scopus 로고    scopus 로고
    • Amperometric glucose biosensor based on a gold nanorods/cellulose acetate composite film as immobilization matrix
    • Ren, X., Chen, D., Meng, X., Tang, F., Du, A. and Zhang, L. (2009) 'Amperometric glucose biosensor based on a gold nanorods/cellulose acetate composite film as immobilization matrix', Colloids Surf., B, Vol. 72, No. 2, pp.188-192.
    • (2009) Colloids Surf., B , vol.72 , Issue.2 , pp. 188-192
    • Ren, X.1    Chen, D.2    Meng, X.3    Tang, F.4    Du, A.5    Zhang, L.6
  • 44
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller, J.P., Drewe, J., Goke, B., Schmidt, H., Rohrer, B., Lareida, J. and Beglinger, C. (1999) 'Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2', Am. J. Physiol., Vol. 276, No. 5, Pt 2, pp.R1541-R1544.
    • (1999) Am. J. Physiol. , vol.276 , Issue.5 PT. 2
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3    Schmidt, H.4    Rohrer, B.5    Lareida, J.6    Beglinger, C.7
  • 46
    • 85056045824 scopus 로고    scopus 로고
    • New therapeutic strategies for the treatment of type 2 diabetes mellitus based on incretins
    • Gallwitz, B. (2005) 'New therapeutic strategies for the treatment of type 2 diabetes mellitus based on incretins', Rev. Diabet. Stud., Vol. 2, No. 2, pp.61-69.
    • (2005) Rev. Diabet. Stud. , vol.2 , Issue.2 , pp. 61-69
    • Gallwitz, B.1
  • 47
    • 65449183851 scopus 로고    scopus 로고
    • Targeting the CNS to treat type 2 diabetes
    • Sandoval, D.A., Obici, S. and Seeley, R.J. (2009) 'Targeting the CNS to treat type 2 diabetes', Nat. Rev. Drug Discovery, Vol. 8, No. 5, pp.386-398.
    • (2009) Nat. Rev. Drug Discovery , vol.8 , Issue.5 , pp. 386-398
    • Sandoval, D.A.1    Obici, S.2    Seeley, R.J.3
  • 48
    • 0036065628 scopus 로고    scopus 로고
    • Central administration of oleic acid inhibits glucose production and food intake
    • Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G. and Rossetti, L. (2002) 'Central administration of oleic acid inhibits glucose production and food intake', Diabetes, Vol. 51, No. 2, pp.271-275.
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 271-275
    • Obici, S.1    Feng, Z.2    Morgan, K.3    Stein, D.4    Karkanias, G.5    Rossetti, L.6
  • 49
    • 70749114154 scopus 로고    scopus 로고
    • Nanoparticles as drug delivery agents specific for CNS: In vivo biodistribution
    • Vergoni, A.V., Tosi, G., Tacchi, R., Vandelli, M.A., Bertolini, A. and Costantino, L. (2009) 'Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution', Nanomedicine, Vol. 5, No. 4, pp.369-377.
    • (2009) Nanomedicine , vol.5 , Issue.4 , pp. 369-377
    • Vergoni, A.V.1    Tosi, G.2    Tacchi, R.3    Vandelli, M.A.4    Bertolini, A.5    Costantino, L.6
  • 51
    • 46649095604 scopus 로고    scopus 로고
    • Improved bioavailability of orally delivered insulin using Eudragit-L30D coated PLGA microparticles
    • Naha, P.C., Kanchan, V., Manna, P.K. and Panda, A.K. (2008) 'Improved bioavailability of orally delivered insulin using Eudragit-L30D coated PLGA microparticles', J. Microencapsulation, Vol. 25, No. 4, pp.248-256.
    • (2008) J. Microencapsulation , vol.25 , Issue.4 , pp. 248-256
    • Naha, P.C.1    Kanchan, V.2    Manna, P.K.3    Panda, A.K.4
  • 52
    • 0035185638 scopus 로고    scopus 로고
    • Enhancement of absorption of insulin-loaded polyisobutylcyanoacrylate nanospheres by sodium cholate after oral and subcutaneous administration in diabetic rats
    • Radwan, M.A. (2001) 'Enhancement of absorption of insulin-loaded polyisobutylcyanoacrylate nanospheres by sodium cholate after oral and subcutaneous administration in diabetic rats', Drug Dev. Ind. Pharm., Vol. 27, No. 9, pp.981-989.
    • (2001) Drug Dev. Ind. Pharm. , vol.27 , Issue.9 , pp. 981-989
    • Radwan, M.A.1
  • 53
    • 33847666114 scopus 로고    scopus 로고
    • Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery
    • Cui, F.D., Tao, A.J., Cun, D.M., Zhang, L.Q. and Shi, K. (2007) 'Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery', J. Pharm. Sci., Vol. 96, No. 2, pp.421-427.
    • (2007) J. Pharm. Sci. , vol.96 , Issue.2 , pp. 421-427
    • Cui, F.D.1    Tao, A.J.2    Cun, D.M.3    Zhang, L.Q.4    Shi, K.5
  • 54
    • 0033995073 scopus 로고    scopus 로고
    • Nanosphere based oral insulin delivery
    • Carino, G.P., Jacob, J.S. and Mathiowitz, E. (2000) 'Nanosphere based oral insulin delivery', J. Control Release, Vol. 65, Nos. 1-2, pp.261-269.
    • (2000) J. Control Release , vol.65 , Issue.1-2 , pp. 261-269
    • Carino, G.P.1    Jacob, J.S.2    Mathiowitz, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.