An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling

Biochemical Journal

Volumn 442, Issue 2, 2012, Pages 323-334

  Pérez Siles, Gonzalo ^a,b   Núñez, Enrique ^a,b,c   Morreale, Antonio ^a   Jiménez, Esperanza ^a,b,c   Leo Macías, Alejandra ^a   Pita, Guillermo ^a   Cherubino, Francesca ^d,e   Sangaletti, Rachele ^d   Bossi, Elena ^d   Ortíz, Ángel R ^a   Aragón, Carmen ^a,b,c   López Corcuera, Beatriz ^a,b,c  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e IRCCS   (Italy)

Author keywords

Glycine; Glycine transporter (GLYT); Lithium; Neurotransmitter sodium symporter; Residue accessibility; Sodium coupling

Indexed keywords

ASPARTIC ACID; GLYCINE; GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 2; LITHIUM ION; MUTANT PROTEIN; SODIUM ION;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; SIMULATION; SODIUM TRANSPORT;

AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; ION TRANSPORT; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; OOCYTES; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM; SPIRO COMPOUNDS; XENOPUS LAEVIS;

EID: 84856812439     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110247     Document Type: Article

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