Age exacerbates sickness behavior following exposure to a viral mimetic

Physiology and Behavior

Volumn 105, Issue 5, 2012, Pages 1219-1225

  McLinden, Kristina A ^a   Kranjac, Dinko ^a   Deodati, Lauren E ^a   Kahn, Marielle ^a   Chumley, Michael J ^a   Boehm, Gary W ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

Aging; Burrowing; C57BL 6 mice; Cytokines; Polyinosinic polycitidylic acid; Sickness behavior

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; POLYINOSINIC POLYCYTIDYLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; BURROWING SPECIES; CONTROLLED STUDY; HIPPOCAMPUS; ILLNESS BEHAVIOR; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PARIETAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS ACTIVATION;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BIOMIMETIC MATERIALS; CHEMOKINES; CYTOKINES; HIPPOCAMPUS; ILLNESS BEHAVIOR; INTERLEUKINS; MALE; MICE; MICE, INBRED C57BL; PARIETAL LOBE; POLY I-C;

EID: 84856790588     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.04.024     Document Type: Article

References (33)

1. Fulop T., Larbi A., Douziech N., Fortin C., Guerard K.P., Lesur O., et al. Signal transduction and functional changes in neutrophils with aging. Aging Cell 2004, 3:217-226.
2. Sebastian C., Espia M., Serra M., Celada A., Lloberas J. MacrophAging: a cellular and molecular review. Immunobiology 2005, 210:121-126.
3. Miller J.F. Immunological function of the thymus. Lancet 1961, 2:748-749.
4. Aw D., Silva A.B., Palmer D.B. Immunosenescence: emerging challenges for an aging population. Immunology 2007, 120:435-446.
5. Hasler P., Zouali M. Immune receptor signaling, aging, and autoimmunity. Cell Immunol 2005, 233:102-108.
6. Kluger M.J. Fever: role of pyrogens and cryogens. Physiol Rev 1991, 71(1):93-127.
7. Dantzer R. Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity. Eur J Pharmacol 2004, 500:399-411.
8. Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., et al. Exaggerated neuroninflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 2005, 19:1329-1331.
9. Huang Y., Henry C.J., Dantzer R., Johnson R.W., Godbout J.P. Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging 2008, 11:1744-1753.
10. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappa B by toll-like receptor 3. Nature 2001, 21:490-502.
11. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004, 5:730-737.
12. Yoneyama M., Kikuchi M., Matsumoto K., Imaizumi T., Miyagishi M., Taira K., et al. Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 2005, 175:851-2858.
13. Botos I., Liu L., Segal D.M., Davies D.R. The toll-like receptor 3: dsRNA signaling complex. Biochim Biophys Acta 2009, 1789:667-674.
14. Itoh K., Watanabe A., Funami K., Tsukasa S., Matsumoto M. The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-β production. J Immunol 2008, 181:5522-5529.
15. Lee H.K., Dunzendorfer S., Soldau K., Tobias P.S. Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity 2006, 24:153-163.
16. Konat G.W., Borysiewicz E., Fil D., James I. Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain. J Neurol Res 2009, 87:1381-1388.
17. Majde J.A. Viral double-stranded RNA, cytokines and the flu. J Interferon Cytokine Res 2000, 20:259-272.
18. Zhang Y., Cazakoff B.N., Thai C.A., Howland J.G. Prenatal exposure to a viral mimetic alters behavioural flexibility in male, but not female, rats. Neuropharmacology 2011, 10.1016/j.neuropharm.2011.02.022.
19. Kimura M., Toth L.A., Agostini H., Cady A.B., Majde J.A., Krueger J.M. Comparison of acute phase responses induced in rabbits by lipopolysaccharide and double-stranded RNA. Am J Physiol 1994, 267:R1596-R1605.
20. Fortier M.E., Kent S., Ashdown H., Poole S., Boksa P., Luheshi G.N. The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism. Am J Physiol Regul Integr Comp Physiol 2004, 287:R759-R766.
21. Katafuchi T., Kondo T., Yasaka T., Kubo K., Take S., Yoshimura M. Prolonged effects of polyribosinic:polyribocytidilic acid on spontaneous running wheel activity and brain interferon-α mRNA in rats: a model for immunologically induced fatigue. Neuroscience 2003, 120:837-845.
22. Matsumoto T., Takahasi H., Shiva D., Kawanishi N., Kremenik M.J., Kato Y., et al. The reduction of voluntary physical activity after poly I:C injection is independent of the effect of poly I:C-induced interferon-beta in mice. Physiol Behav 2008, 93:835-841.
23. Cunningham C., Campion S., Teeling J., Felton L., Perry V.H. The sickness behavior and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C). Brain Behav Immun 2007, 21:490-502.
24. Hopwood N., Maswanganyi T., Harden L.M. Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats. Can J Physiol Pharmacol 2009, 87:211-220.
25. Field R., Campion S., Warren C., Murray C., Cunningham C. Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav Immun 2010, 24:996-1007.
26. Deacon R.M. Burrowing in rodents: a sensitive measure of behavioral dysfunction. Nat Protoc 2006, 1:118-121.
27. Teeling J.L., Felton L.M., Deacon R.M.J., Cunningham C., Rawlins J.N.P., Perry V.H. Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines. Brain Behav Immun 2007, 21:836-850.
28. Peirson S.N., Butler J.N., Foster R.G. Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 2003, 31:e73.
29. Frank M.G., Baratta M.V., Sprunger D.B., Watkins L.R., Maier S.F. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun 2007, 21:47-59.
30. Prechel M.M., Halbur L., Devata S., Vaidya A.M., Young M.R. Increased interleukin-6 production by cerebral cortical tissue of adult versus young mice. Mech Ageing Dev 1996, 92:185-194.
31. Ye S.M., Johnson R.W. Increased interleukin-6 expression by microglia from brain of aged mice. J Neuroimmunol 1999, 93:139-148.
32. Ye S.M., Johnson R.W. An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice. Neuroimmunomodulation 2001, 9:183-192.
33. Salem M.L., El-Naggar S.A., Kadima A., Gillanders W.E., Cole D.J. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 2006, 24:5119-5132.