Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain

Journal of Neuroscience Research

Volumn 87, Issue 6, 2009, Pages 1381-1388

  Konat, Gregory W ^a   Borysiewicz, Elizabeth ^a   Fil, Daniel ^a   James, Isaac ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute antiviral response; Chemokines; Cytokines; Neuroinflammation; NOS

Indexed keywords

BETA INTERFERON; CXCL2 CHEMOKINE; CYTOKINE; DOUBLE STRANDED RNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEURONAL NITRIC OXIDE SYNTHASE; POLYINOSINIC POLYCYTIDYLIC ACID; TUMOR NECROSIS FACTOR ALPHA; CCL2 PROTEIN, MOUSE; CXCL2 PROTEIN, MOUSE; NOS1 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOREBRAIN; GENE EXPRESSION REGULATION; GENE LOCATION; ILLNESS BEHAVIOR; INNATE IMMUNITY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; VIRUS INFECTION; VIRUS REPLICATION; ANIMAL; BRAIN; C57BL MOUSE; CENTRAL NERVOUS SYSTEM INFECTION; DISEASE MODEL; GENETICS; IMMUNOLOGY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; CHEMOKINE CCL2; CHEMOKINE CXCL2; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; INTERFERON-BETA; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; POLY I-C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, DOUBLE-STRANDED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 65549128705     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21958     Document Type: Article

References (27)

1. Adler MW, Rogers TJ. 2005. Are chemokines the third major system in the brain? J Leukocyte Biol 78:1204-1209.
2. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:732-738.
3. Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, Randall RE. 2004. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A 101:17264-17269.
4. Crnic LS, Segall MA. 1992. Prostaglandins do not mediate interferon-alpha effects on mouse behavior. Physiol Behav 51:349-352.
5. Cross AH, O'Mara T, Raine CS. 1993. Chronologic localization of myelin-reactive cells in the lesions of relapsing EAE: implications for the study of multiple sclerosis. Neurology 43:1028-1033.
6. Cunningham C, Campion S, Teeling J, Felton L, Perry VH. 2007. The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C). Brain Behav Immun 21:490-502.
7. Dantzer R. 2006. Cytokine, sickness behavior, and depression. Neurol Clin 24:441-460.
8. Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN. 2004. The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism. Am J Physiol Regul Integr Comp Physiol 287:R759-R766.
9. Guha-Thakurta N, Majde JA. 1997. Early induction of proinflammatory cytokine and type I interferon mRNAs following Newcastle disease virus, poly [rI:rC], or low-dose LPS challenge of the mouse. J Interferon Cytokine Res 17:197-204.
10. Jacobs BL, Langland JO. 1996. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219:339-349.
11. Juhler M, Barry DI, Offner H, Konat G, Klinken L, Paulson OB. 1984. Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat. Brain Res 302:347-355.
12. Kalehua AN, Nagel JE, Whelchel LM, Gides JJ, Pyle RS, Smith RJ, Kusiak JW, Taub DD. 2004. Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. Exp Cell Res 297:197-211.
13. Katafuchi T, Kondo T, Take S, Yoshimura M. 2005. Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. Eur J Neurosci 22:2817-2826.
14. Mahad DJ, Ransohoff RM. 2003. The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Semin Immunol 15:23-32.
15. Majde JA. 2000. Viral double-stranded RNA, cytokines, and the flu. J Interferon Cytokine Res 20:259-272.
16. Meylan E, Tschopp J. 2006. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 22:561-569.
17. Muller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM, Aguet M. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
18. Phares TW, Kean RB, Mikheeva T, Hooper DC. 2006. Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system. J Immunol 176:7666-7675.
19. Pruett SB, Schwab C, Zheng Q, Fan R. 2004. Suppression of innate immunity by acute ethanol administration: a global perspective and a new mechanism beginning with inhibition of signaling through TLR3. J Immunol 173:2715-2724.
20. Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT. 2007. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55:453-462.
21. Segall MA, Crnic LS. 1990. An animal model for the behavioral effects of interferon. Behav Neurosci 104:612-618.
22. Shimojo N, Jesmin S, Zaedi S, Maeda S, Gando S, Yamaguchi I, Goto K, Miyauchi T. 2006. Alterations of gene expressions of preproET-1 and ET receptors in brains of endotoxemic Sprague-Dawley rats. Exp Biol Med 231:1058-1063.
23. Silwedel C, Forster C. 2006. Differential susceptibility of cerebral and cerebellar murine brain microvascular endothelial cells to loss of barrier properties in response to inflammatory stimuli. J Neuroimmunol 179:37-45.
24. Traynor TR, Majde JA, Bohnet SG, Krueger JM. 2004. Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections. Life Sci 74:2563-2576.
25. Turrin NP, Gayle D, Ilyin SE, Flynn MC, Langhans W, Schwartz GJ, Plata-Salaman CR. 2001. Proinflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Res Bull 54:443-453.
26. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T. 2004. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5:730-737.
27. Zwijnenburg PJ, Polfliet MM, Florquin S, van den Berg TK, Dijkstra CD, van Deventer SJ, Roord JJ, van der PT, van Furth AM. 2003. CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats. Immunol Lett 85:1-4.