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Volumn 178, Issue 2, 2011, Pages 525-536

Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; ANDROGEN RECEPTOR; ARACHIDONIC ACID; BIOLOGICAL MARKER; CYTOCHROME P450 4F8; EPOXIDE HYDROLASE 2; FLUTAMIDE; MESSENGER RNA; PHOSPHOLIPASE A2; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 79951825010     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.10.002     Document Type: Article
Times cited : (97)

References (54)
  • 3
    • 33645690200 scopus 로고    scopus 로고
    • Mechanisms underlying the development of androgen-independent prostate cancer
    • Pienta KJ, Bradley D: Mechanisms underlying the development of androgen-independent prostate cancer. Clin Cancer Res 2006, 12:1665-1671
    • (2006) Clin Cancer Res , vol.12 , pp. 1665-1671
    • Pienta, K.J.1    Bradley, D.2
  • 5
    • 54849435425 scopus 로고    scopus 로고
    • Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
    • Dillard PR, Lin MF, Khan SA: Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol 2008;295:115-120
    • (2008) Mol Cell Endocrinol , vol.295 , pp. 115-120
    • Dillard, P.R.1    Lin, M.F.2    Khan, S.A.3
  • 6
    • 67449119425 scopus 로고    scopus 로고
    • Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven
    • Attard G, Reid AH, Olmos D, de Bono JS: Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven. Cancer Res 2009, 69:4937-4940
    • (2009) Cancer Res , vol.69 , pp. 4937-4940
    • Attard, G.1    Reid, A.H.2    Olmos, D.3    De Bono, J.S.4
  • 7
    • 41949111209 scopus 로고    scopus 로고
    • The arachidonic acid pathway and its role in prostate cancer development and progression
    • Patel MI, Kurek C, Dong Q: The arachidonic acid pathway and its role in prostate cancer development and progression. J Urol 2008, 179:1668-1675
    • (2008) J Urol , vol.179 , pp. 1668-1675
    • Patel, M.I.1    Kurek, C.2    Dong, Q.3
  • 8
    • 0026356575 scopus 로고
    • Essential fatty acid distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease
    • Chaudry A, McClinton S, Moffat LE, Wahle KW: Essential fatty acid distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease. Br J Cancer 1991, 64:1157-1160
    • (1991) Br J Cancer , vol.64 , pp. 1157-1160
    • Chaudry, A.1    McClinton, S.2    Moffat, L.E.3    Wahle, K.W.4
  • 9
    • 0029126051 scopus 로고
    • Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet
    • Wang Y, Corr JG, Thaler HT, Tao Y, Fair WR, Heston WD: Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet. J Natl Cancer Inst 1995, 87:1456-1462
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1456-1462
    • Wang, Y.1    Corr, J.G.2    Thaler, H.T.3    Tao, Y.4    Fair, W.R.5    Heston, W.D.6
  • 10
    • 0031577170 scopus 로고    scopus 로고
    • Arachidonic acid stimulates prostate cancer cell growth: Critical role of 5-lipoxygenase
    • DOI 10.1006/bbrc.1997.6799
    • Ghosh J, Myers CE: Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun 1997, 235:418-423 (Pubitemid 27313723)
    • (1997) Biochemical and Biophysical Research Communications , vol.235 , Issue.2 , pp. 418-423
    • Ghosh, J.1    Myers, C.E.2
  • 12
    • 33749612562 scopus 로고    scopus 로고
    • What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
    • Fürstenberger G, Krieg P, Müller-Decker K, Habenicht AJ: What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? Int J Cancer 2006, 119:2247-2254
    • (2006) Int J Cancer , vol.119 , pp. 2247-2254
    • Fürstenberger, G.1    Krieg, P.2    Müller-Decker, K.3    Habenicht, A.J.4
  • 13
    • 79551647739 scopus 로고    scopus 로고
    • The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer
    • Matsuyama M, Yoshimura R: The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer. Biologics 2008, 2:725-732
    • (2008) Biologics , vol.2 , pp. 725-732
    • Matsuyama, M.1    Yoshimura, R.2
  • 14
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang D, Dubois RN: Eicosanoids and cancer. Nat Rev Cancer 2010, 10:181-193
    • (2010) Nat Rev Cancer , vol.10 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 15
    • 0034646688 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2
    • DOI 10.1074/jbc.275.15.11397
    • Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM, Chen CS: The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem 2000, 275:11397-11403 (Pubitemid 30212792)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.15 , pp. 11397-11403
    • Hsu, A.-L.1    Ching, T.-T.2    Wang, D.-S.3    Song, X.4    Rangnekar, V.M.5    Chen, C.-S.6
  • 16
    • 9344225155 scopus 로고    scopus 로고
    • Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model
    • DOI 10.1158/1078-0432.CCR-04-0732
    • Narayanan BA, Narayanan NK, Pittman B, Reddy BS: Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. Clin Cancer Res 2004, 10:7727-7737 (Pubitemid 39557538)
    • (2004) Clinical Cancer Research , vol.10 , Issue.22 , pp. 7727-7737
    • Narayanan, B.A.1    Narayanan, N.K.2    Pittman, B.3    Reddy, B.S.4
  • 18
    • 33744976771 scopus 로고    scopus 로고
    • Do selective cyclo-oxygenase-2 inhibitors and traditional nonsteroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
    • Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR and Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional nonsteroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ 2006, 332:1302-1308
    • (2006) BMJ , vol.332 , pp. 1302-1308
    • Kearney, P.M.1    Baigent, C.2    Godwin, J.3    Halls, H.4    Emberson, J.R.5    Patrono, C.6
  • 19
    • 4544351939 scopus 로고    scopus 로고
    • Activation of the orphan nuclear receptor RORα counteracts the proliferative effect of fatty acids on prostate cancer cells: Crucial role of 5-lipoxygenase
    • DOI 10.1002/ijc.20387
    • Moretti RM, Montagnani Marelli M, Sala A, Motta M, Limonta P: Activation of the orphan nuclear receptor RORalpha counteracts the proliferative effect of fatty acids on prostate cancer cells: crucial role of 5-lipoxygenase. Int J Cancer 2004, 112:87-93 (Pubitemid 39249495)
    • (2004) International Journal of Cancer , vol.112 , Issue.1 , pp. 87-93
    • Moretti, R.M.1    Marelli, M.M.2    Sala, A.3    Motta, M.4    Limonta, P.5
  • 21
    • 0028265777 scopus 로고
    • Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: Effects of fatty acids and cyclooxygenase inhibitors
    • Chaudry AA, Wahle KW, McClinton S, Moffat LE: Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: effects of fatty acids and cyclooxygenase inhibitors. Int J Cancer 1994, 57:176-180 (Pubitemid 24144205)
    • (1994) International Journal of Cancer , vol.57 , Issue.2 , pp. 176-180
    • Chaudry, A.A.1    Wahle, K.W.J.2    McClinton, S.3    Moffat, L.E.F.4
  • 23
    • 54249155141 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates tumor angiogenesis in prostate cancer
    • Jain S, Chakraborty G, Raja R, Kale S, Kundu GC: Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. Cancer Res 2008, 68:7750-7759
    • (2008) Cancer Res , vol.68 , pp. 7750-7759
    • Jain, S.1    Chakraborty, G.2    Raja, R.3    Kale, S.4    Kundu, G.C.5
  • 25
    • 33751260934 scopus 로고    scopus 로고
    • TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
    • DOI 10.1158/0008-5472.CAN-06-1986
    • Iljin K, Wolf M, Edgren H, Gupta S, Kilpinen S, Skotheim RI, Peltola M, Smit F, Verhaegh G, Schalken J, Nees M, Kallioniemi O: TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. Cancer Res 2006, 66:10242-10246 (Pubitemid 44799738)
    • (2006) Cancer Research , vol.66 , Issue.21 , pp. 10242-10246
    • Iljin, K.1    Wolf, M.2    Edgren, H.3    Gupta, S.4    Kilpinen, S.5    Skotheim, R.I.6    Peltola, M.7    Smit, F.8    Verhaegh, G.9    Schalken, J.10    Nees, M.11    Kallioniemi, O.12
  • 26
    • 0001901131 scopus 로고    scopus 로고
    • Androgen receptor in human prostate carcinoma LNCaP/ADEP cells contains a mutation which alters the specificity of the steroid dependent transcriptional activation region
    • Program and Abstracts
    • Harris SE, Rong Z, Harris MA, Lubahn DB: Androgen receptor in human prostate carcinoma LNCaP/ADEP cells contains a mutation which alters the specificity of the steroid dependent transcriptional activation region. Program and Abstracts, 72nd Annual Meeting of the Endocrine Society, Atlanta, GA. 1990:93
    • 72nd Annual Meeting of the Endocrine Society, Atlanta, GA. 1990 , pp. 93
    • Harris, S.E.1    Rong, Z.2    Harris, M.A.3    Lubahn, D.B.4
  • 28
    • 3242669872 scopus 로고    scopus 로고
    • Improved statistical methods for hit selection in high-throughput screening
    • Brideau C, Gunter B, Pikounis B Liaw A: Improved statistical methods for hit selection in high-throughput screening. J Biomol Screen 2003, 6:634-647
    • (2003) J Biomol Screen , vol.6 , pp. 634-647
    • Brideau, C.1    Gunter, B.2    Pikounis, B.3    Liaw, A.4
  • 32
    • 33845330927 scopus 로고    scopus 로고
    • 15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size)
    • Tang DG, Bhatia B, Tang S, Schneider-Broussard R: 15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size). Prostaglandins Other Lipid Mediat 2007;82:135-146
    • (2007) Prostaglandins Other Lipid Mediat , vol.82 , pp. 135-146
    • Tang, D.G.1    Bhatia, B.2    Tang, S.3    Schneider-Broussard, R.4
  • 33
    • 58549097440 scopus 로고    scopus 로고
    • Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2)
    • Stafforini DM: Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2). Cardiovasc Drugs Ther 2009, 23:73-83
    • (2009) Cardiovasc Drugs Ther , vol.23 , pp. 73-83
    • Stafforini, D.M.1
  • 34
    • 0034698139 scopus 로고    scopus 로고
    • Identification of CYP4F8 in human seminal vesicles as a prominent 19-Hydroxylase of prostaglandin endoperoxides
    • DOI 10.1074/jbc.M001712200
    • Bylund J, Hidestrand M, Ingelman-Sundberg M, Oliw EH: Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides. J Biol Chem 2000, 275:21844-21849 (Pubitemid 30621753)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 21844-21849
    • Bylund, J.1    Hidestrand, M.2    Ingelman-Sundberg, M.3    Oliw, E.H.4
  • 35
    • 58149229504 scopus 로고    scopus 로고
    • Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis
    • [Erratum appeared in Breast Cancer Res Treat 2009, 113:251-252].
    • Thomassen M, Tan Q, Kruse TA: Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis [Erratum appeared in Breast Cancer Res Treat 2009, 113:251-252]. Cancer Res Treat 2009, 113:239-249
    • (2009) Cancer Res Treat , vol.113 , pp. 239-249
    • Thomassen, M.1    Tan, Q.2    Kruse, T.A.3
  • 41
    • 39449097368 scopus 로고    scopus 로고
    • Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms
    • Enayetallah AE, French RA, Grant DF: Distribution of soluble epoxide hydrolase, cytochrome P450 2C8, 2C9 and 2J2 in human malignant neoplasms. J Mol Histol 2006, 37:133-141
    • (2006) J Mol Histol , vol.37 , pp. 133-141
    • Enayetallah, A.E.1    French, R.A.2    Grant, D.F.3
  • 43
    • 51749090888 scopus 로고    scopus 로고
    • Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: A case-control study
    • Kim JY, Hyun YJ, Jang Y, Lee BK, Chae JS, Kim SE, Yeo HY, Jeong TS, Jeon DW, Lee JH: Lipoprotein-associated phospholipase A2 activity is associated with coronary artery disease and markers of oxidative stress: a case-control study. Am J Clin Nutr 2008, 88:630-637
    • (2008) Am J Clin Nutr , vol.88 , pp. 630-637
    • Kim, J.Y.1    Hyun, Y.J.2    Jang, Y.3    Lee, B.K.4    Chae, J.S.5    Kim, S.E.6    Yeo, H.Y.7    Jeong, T.S.8    Jeon, D.W.9    Lee, J.H.10
  • 44
    • 33749641286 scopus 로고    scopus 로고
    • Metallothionein redox cycle and function
    • (Maywood)
    • Kang YJ: Metallothionein redox cycle and function. Exp Biol Med (Maywood) 2006, 231:1459-1467
    • (2006) Exp Biol Med , vol.231 , pp. 1459-1467
    • Kang, Y.J.1
  • 45
    • 70349665204 scopus 로고    scopus 로고
    • High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth
    • Iljin K, Ketola K, Vainio P, Halonen P, Kohonen P, Fey V, GrafströM RC, Perälä M, Kallioniemi O: High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res 2009, 15:6070-6078
    • (2009) Clin Cancer Res , vol.15 , pp. 6070-6078
    • Iljin, K.1    Ketola, K.2    Vainio, P.3    Halonen, P.4    Kohonen, P.5    Fey, V.6    GrafströM, R.C.7    Perälä, M.8    Kallioniemi, O.9
  • 47
    • 0027377193 scopus 로고
    • 2-receptor antagonist
    • DOI 10.1016/0090-6980(93)90102-D
    • Woodward DF, Protzman CE, Krauss AH, Williams LS: Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. Prostaglandins 1993, 46:371-383 (Pubitemid 23308673)
    • (1993) Prostaglandins , vol.46 , Issue.4 , pp. 371-383
    • Woodward, D.F.1    Protzman, C.E.2    Krauss, A.H.-P.3    Williams, L.S.4
  • 48
    • 35848955898 scopus 로고    scopus 로고
    • 2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway
    • DOI 10.1002/mc.20320
    • Wang X, Klein RD: Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway. Mol Carcinog 2007, 46:912-923 (Pubitemid 350058411)
    • (2007) Molecular Carcinogenesis , vol.46 , Issue.11 , pp. 912-923
    • Wang, X.1    Klein, R.D.2
  • 50
    • 0029150467 scopus 로고
    • Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice
    • Pinot F, Grant DF, Spearow JL, Parker AG, Hammock BD: Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice. Biochem Pharmacol 1995, 50:501-508
    • (1995) Biochem Pharmacol , vol.50 , pp. 501-508
    • Pinot, F.1    Grant, D.F.2    Spearow, J.L.3    Parker, A.G.4    Hammock, B.D.5
  • 51
    • 0034675271 scopus 로고    scopus 로고
    • Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells
    • Tong M, Tai HH: Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Biochem Biophys Res Commun 2000, 276:77-81
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 77-81
    • Tong, M.1    Tai, H.H.2
  • 52
    • 61349123574 scopus 로고    scopus 로고
    • Group IIA phospholipase A as a prognostic marker in prostate cancer: Relevance to clinicopathological variables and disease-specific mortality
    • Mirtti T, Laine VJ, Hiekkanen H, Hurme S, Rowe O, Nevalainen TJ, Kallajoki M, Alanen K: Group IIA phospholipase A as a prognostic marker in prostate cancer: relevance to clinicopathological variables and disease-specific mortality. APMIS 2009, 117:151-161
    • (2009) APMIS , vol.117 , pp. 151-161
    • Mirtti, T.1    Laine, V.J.2    Hiekkanen, H.3    Hurme, S.4    Rowe, O.5    Nevalainen, T.J.6    Kallajoki, M.7    Alanen, K.8
  • 53
    • 61449149630 scopus 로고    scopus 로고
    • Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer
    • Tang Y, Wang MT, Chen Y, Yang D, Che M, Honn KV, Akers GD, Johnson SR, Nie D: Downregulation of vascular endothelial growth factor and induction of tumor dormancy by 15-lipoxygenase-2 in prostate cancer. Int J Cancer 2009, 124:1545-1551
    • (2009) Int J Cancer , vol.124 , pp. 1545-1551
    • Tang, Y.1    Wang, M.T.2    Chen, Y.3    Yang, D.4    Che, M.5    Honn, K.V.6    Akers, G.D.7    Johnson, S.R.8    Nie, D.9


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