CGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function

Nature Medicine

Volumn 18, Issue 2, 2012, Pages 252-259

  Jaumann, Mirko ^a   Dettling, Juliane ^a   Gubelt, Martin ^a   Zimmermann, Ulrike ^a   Gerling, Andrea ^b   Paquet Durand, Franãois ^a   Feil, Susanne ^b   Wolpert, Stephan ^a   Franz, Christoph ^a   Varakina, Ksenya ^a   Xiong, Hao ^a   Brandt, Niels ^b,c   Kuhn, Stephanie ^b,f   Geisler, Hyun Soon ^a   Rohbock, Karin ^a   Ruth, Peter ^b   Schlossmann, Jens ^d   Hütter, Joachim ^e   Sandner, Peter ^e   Feil, Robert ^b   Engel, Jutta ^b,c   Knipper, Marlies ^a   Rüttiger, Lukas ^a   more..

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e BAYER PHARMA AG   (Germany)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE TYPE 1; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PHOSPHODIESTERASE V; POLY(ADENOSINE DIPHOSPHATE RIBOSE); UNCLASSIFIED DRUG; VARDENAFIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUDITORY THRESHOLD SHIFT; COCHLEA; COCHLEAR NERVE; CONTROLLED STUDY; EAR PROTECTION; ENZYME ACTIVITY; ENZYME INHIBITION; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; GENE DELETION; GENE EXPRESSION PROFILING; GENETIC SUSCEPTIBILITY; HAIR CELL; HEARING; HYDROLYSIS; MOUSE; NERVE CELL; NOISE INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVIEW; SATELLITE CELL; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPIRAL GANGLION; UPREGULATION; WILD TYPE;

ANIMALS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENZYME ACTIVATION; FEMALE; HAIR CELLS, AUDITORY; HAIR CELLS, AUDITORY, INNER; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS, NOISE-INDUCED; IMIDAZOLES; MICE; MICE, MUTANT STRAINS; NOISE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SULFONES; TRIAZINES; UP-REGULATION;

MUS; RATTUS;

EID: 84856733306     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2634     Document Type: Review

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