High dosage sildenafil induces hearing impairment in mice

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 10, 2008, Pages 1981-1984

  Hong, Bin Na ^a   Yi, Tae Hoo ^b   Kim, Sun Yeou ^b   Kang, Tong Ho ^a  

^a Nambu University   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Hearing impairment; Mouse; Ototoxicity; Sildenafil; Viagra

Indexed keywords

SILDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY MIDDLE LATENCY RESPONSE; AUDITORY THRESHOLD; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; EVOKED BRAIN STEM AUDITORY RESPONSE; EVOKED OTOACOUSTIC EMISSION; HEARING IMPAIRMENT; MALE; MOUSE; NONHUMAN;

ANIMALS; COCHLEA; COCHLEAR NERVE; DOSE-RESPONSE RELATIONSHIP, DRUG; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEARING LOSS, SENSORINEURAL; MALE; MICE; MICE, INBRED ICR; OTOACOUSTIC EMISSIONS, SPONTANEOUS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; SULFONES;

EID: 53549088644     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1981     Document Type: Article

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