Prenatal methylmercury exposure and developmental outcomes: Review of the evidence and discussion of future directions

Environmental Health Perspectives

Volumn 114, Issue 2, 2006, Pages 307-312

  Spurgeon, Anne ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Developmental outcomes; Methylmercury; Neurobehavioral tests; Prenatal exposure

Indexed keywords

METHYLMERCURY;

CHILD DEVELOPMENT; COGNITION; DEVELOPMENTAL DISORDER; ENVIRONMENTAL HEALTH; FAROE ISLANDS; FOOD CONTAMINATION; FOOD INTAKE; HUMAN; INTELLIGENCE QUOTIENT; LONGITUDINAL STUDY; NEUROLOGIC EXAMINATION; NEUROTOXICITY; OUTCOMES RESEARCH; PRENATAL EXPOSURE; PRIORITY JOURNAL; SEA FOOD; SEYCHELLES; SHORT SURVEY;

ADULT; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DEVELOPMENTAL DISABILITIES; DIET; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD CONTAMINATION; HUMANS; INFANT; INFANT, NEWBORN; INTELLIGENCE; LONGITUDINAL STUDIES; MALE; METHYLMERCURY COMPOUNDS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEAFOOD;

EID: 32044450826     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.7859     Document Type: Short Survey

References (82)

1. Amin-Zaki L, Elhassani S, Majeed MA, Clarkson TW, Doherty RA, Greenwood M. 1974, Intra-uterine methylmercury poisoning in Iraq. Pediatrics 54(5):587-595.
2. Annau Z, Eccles CU. 1986. Prenatal exposure. In: Neurobehavioral Toxicology (Annau Z, ed). Baltimore, MD:Johns Hopkins University Press, 153-169.
3. Axelson G, Rylander R. 1984. Validation of questionnaire reported miscarriage, malformation and birth weight. Int J Epidemiol 13(1)94-98.
4. Axtell CD, Cox C, Myers GJ, Davidson PW. Choi AL, Cernichiari E, et al. 2000. Association between methylmercury exposure from fish consumption and child development at five and a half years of age in the Seychelles Child Development Study: an evaluation of nonlinear relationships. Environ Res 84:71-80.
5. Axtell CD, Myers GJ, Davidson PW, Choi AL, Cernichiari E, Sloane-Reeves J, et al. 1998. Semiparametric modeling of age at achieving milestones after prenatal exposure to methylmercury in the Seychelles Child Development Study. Environ Health Perspect 106:559-564.
6. Baddeley AD. 1987. Working Memory. Oxford, UK:Oxford University Press.
7. British Psychological Society. 2001. Psychological Testing: A User's Guide, Leicester, UK:BPS Publications.
8. Budtz-Jorgensen E, Grandjean P, Keiding N, White RF, Weihe P. 2000. Benchmark dose calculations of methylmercury-associated neurobehavioral deficits. Toxicol Lett 112-113:193-199.
9. Budtz-Jorgensen E, Keiding N, Grandjean P, Weihe P. 2002. Estimation of health effects of prenatal methylmercury exposure using structural equation models. Environ Health 1:2.
10. Budtz-Jorgensen E, Keiding N, Grandjean P, White RF, Weihe P. 1999. Methylmercury toxicity independent of PCB exposure. Environ Health Perspect 107:A236-A237.
11. Cernichiari E, Brewer R, Myers GJ, Marsh DO, Lowell W, Lapham W, et al. 1995b. Monitoring methylmercury during pregnancy: maternal hair predicts fetal brain exposure. Neurotoxicology 16(4):705-710.
12. Cernichiari E, Torbara T, Liang L, Marsh DO, Berlin MW, Myers GJ, et al. 1995a. The biological monitoring of mercury in the Seychelles study. Neurotoxicology 16(4):613-628.
13. Chipman JK, Cross HJ, Fletcher AC, Levy LS, Smillie MV, Spurgeon A. 1995, Mercury and its divalent compounds. UK Health and Safety Executive Contract Research Report no. 76/1995. Sudbury, Suffolk, UK:HSE Books.
14. Cordier S, Garel M, Mandereau L, Morcel H, Doineau P, Gosme-Seguret S, et al. 2002. Neurodevelopmental investigation among methylmercury-exposed children in French Guiana. Environ Res 89:1-11.
15. Cox C, Breazna A, Davidson PW, Myers GJ, Clarkson TW. 1999, Prenatal and postnatal methylmercury exposure and neuro-developmental outcomes. JAMA 282(14):1333-1334.
16. Crump KS, Kjellstrom T, Shipp AM, Silvers A, Stewert A. 1998. Influence of prenatal mercury exposure upon scholastic and psychological test performance: benchmark analysis of a New Zealand cohort. Risk Anal 18(6):701-713.
17. Crump KS, Van Landingham C, Shamlaye C, Cox C, Davidson PW, Myers GJ, at al. 2000, Benchmark concentrations for methylmercury obtained from the Seychelles Child Development Study. Environ Health Perspect 108:257-263.
18. Davidson PW, Kost J, Myers GJ, Cox C, Clarkson TW, Shamlaye C. 2001. Methylmercury and neurodevelopment: reanalysis of the Seychelles Child Development Study outcomes at 66 months of age. JAMA 285(10):1291-1292.
19. Davidson PW, Myers GJ, Cox C, Axtell C, Shamlaye C, Sloane-Reeves J, et al. 1998. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neuro-development. Outcomes at 66 months of age in the Seychelles Child Development Study. JAMA 280(8):701-707.
20. Davidson PW, Myers GJ, Cox C, Cernichiari E, Clarkson TW. 1999a. Letter to the Editor. JAMA 281(10):897.
21. Davidson PW, Myers GJ, Cox C, Shamlaye C, Choisy O, Sloane-Reeves J, et al. 1995a. Neurodevelopmental test selection, administration and performance in the main Seychelles Child Development Study. Neurotoxicology 16(4):665-676.
22. Davidson PW, Myers GJ, Cox C, Shamlaye C, Marsh DO, Tanner M, et al. 1995b. Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology 16(4):677-688.
23. Davidson PW, Myers GJ, Shamlaye C, Cox C, Gao P, Axtell C, et al. 1999b. Association between prenatal exposure to methylmercury and developmental outcomes in Seychellois: effect modification by social and environmental factors. Neurotoxicology 20(5):833-842.
24. Davidson PW, Palumbo D, Myers GJ, Cox C, Shamlaye C, Sloane-Reeves J, et al. 2000. Neurodevelopmental outcomes of the Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet. Environ Res 84:1-11.
25. Gadzella BM, Hartsoe R, Harper J. 1989. Critical thinking and mental ability groups. Psychol Rep 65:1019-1026.
26. Grandjean P, Budtz-Jorgensen E, Keiding N, Weihe P, Debes F, White RF. 2002a. Underestimation of developmental methylmercury neurotoxicity in the Faroes study [Abstract]. In: Abstract Book of the 8th International Symposium. Neurobehavioral Methods and Effects in Occupational and Environmental Health, 23-26 June 2002, Brescia, Italy.
27. Grandjean P, Budtz-Jorgensen E, White RF, Jorgensen PJ, Weihe P, Debes F, et al. 1999a. Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years. Am J Epidemiol 150(3):301-305.
28. Grandjean P, Weihe P, Burse VW, Needham LL, Storr-Hansen E, Heinzow B, et al. 2001b. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol 23:305-317.
29. Grandjean P, Weihe P, Jorgensen PJ, Clarkson T, Cernichiari E, Videro T. 1992. Impact of maternal seafood diet on fetal exposure to mercury, selenium and lead. Arch Environ Health 47(3)185-195.
30. Grandjean P, Weihe P, White RF. 1995. Milestone development in infants exposed to methylmercury from human milk. Neurotoxicology 16(1):27-34.
31. Grandjean P, Weihe P, White RF, Debes F. 1998. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury. Environ Res 77:15-172.
32. Grandjean P, Weihe P, White RF, Debes F, Araki S. Yokoyama K, et al. 1997. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19(6):417-428.
33. Grandjean P, White RF. 1999. Letter to the editor. JAMA 281(10):896.
34. Grandjean P, White RF, Debes F, Weihe P, Letz R. 2002b. NES2 Continuous performance test results obtained by methylmercury-exposed children at ages 7 and 14 years [Abstract]. In: Abstract Book of the 8th International Symposium. Neurobehavioral Methods and Effects in Occupational and Environmental Health, 23-26 June 2002, Brescia, Italy.
35. Grandjean P, White RF, Nielsen A, Cleary D, de Oliveira Santos EC. 1999b. Methylmercury neurotoxicity in Amazonian children downstream from gold mining. Environ Health Perspect 107:587-591.
36. Grandjean P, White RF, Sullivan K, Debes F, Murata M, Otto D, et al. 2001a. Impact of contrast sensitivity on visually presented neurobehavioral tests in mercury-exposed children. Neurotoxicol Teratol 23:141-146.
37. Grandjean P, White RF, Weihe P, Jorgensen PJ. 2003. Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. Ambul Pediatr 3(1):18-22.
38. Hanson JW, 1997. Human teratology. In: Principles and Practices of Medical Genetics (Rimoin DL, Connor JM, Pyeritz RE, eds). 3rd ed. Vol 1. New York:Churchill Livingstone, 697-724.
39. Harada M. 1995. Minamata Disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol 25(1):1-24.
40. Harvey PG, Hamlin MW, Kumar R, Morgan G, Spurgeon A. 1988. Relationship between blood lead, behaviour, psychometric and neuropsychological test performance in young children. Br J Dev Psychol 6:145-156.
41. Jacobson JL. 2001. Contending with contradictory data in a risk assessment context: the case of methylmercury. Neurotoxicology 22:667-675.
42. Kjellstrom T. 1991. Effects on early childhood development of prenatal exposure to methylmercury, Arch Environ Health 46(2):118.
43. Koller K, Brown T, Spurgeon A, Levy LS. 2004. Recent developments in low-level lead exposure and intellectual impairment in children. Environ Health Perspect 112:987-994.
44. Levy LS, Aitken R, Holmes P, Hughes J, Hurley F, Rumsby P, et al. 2004. Occupational Exposure Limits. Criteria Document for Manganese and Inorganic Manganese Compounds. Leicester, UK:Institute for Environment and Health, University of Leicester. Available: http://www.le.ac.uk/ieh/ publications [accessed 26 November 2005].
45. Lezak MD. 1988, IQ: RIP. J Clin Exp Neuropsychol 10(3):351-361.
46. Marsh DO, Clarkson TW, Myers GJ, Davidson PW, Cox C, Cernichiari E, et al. 1995a. The Seychelles study of fetal methylmercury exposure and child development: introduction. Neurotoxicology 16(4):503-596.
47. Marsh DO, Turner MD, Smith JC, Allen P, Richdale N. 1995b. Fetal methylmercury study in a Peruvian fish-eating population. Neurotoxicology 16(4):717-726.
48. McKeown-Eyssen G, Ruedy J, Neims A. 1983. Methylmercury exposure in northern Quebec. II: Neurological findings in children. Am J Epidemiol 118(4):470-479.
49. Murata K, Budtz-Jorgensen E, Grandjean P. 2002a. Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in two cohorts of children. Risk Anal 22(3):465-473.
50. Murata K, Grandjean P, Weihe P. 2002b. Effect on brainstem auditory evoked potential latencies at ages 7 and 14 years due to prenatal methylmercury exposure [Abstract]. In: Abstract Book of the 8th International Symposium. Neurobehavioral Methods and Effects in Occupational and Environmental Health, 23-26 June 2002, Brescia, Italy.
51. Murata K, Weihe P, Araki S, Budtz-Jorgensen E, Grandjean P. 1999a. Evoked potentials in Faroese children prenatally exposed to methylmercury. Neurotoxicol Teratol 21(4): 471-472.
52. Murata K, Weihe P, Renzoni A, Debes F, Vasconcelos R, Zino F, et al. 1999b. Delayed evoked potentials in children exposed to methylmercury from seafood. Neurotoxicol Teratol 12(4):343-348.
53. Myers GJ, Davidson PW, Cox C, Shamlaye C, Palumbo D, Cernichiari E, et al. 2003. Prenatal methylmercury exposure from ocean fish consumption in the Seychelles Child Development Study. Lancet 361:1686-1692.
54. Myers GJ, Davidson PW, Cox C, Shamlaye C, Tanner M, Choisy O, et al. 1995b. Neurodevelopmental outcomes of Seychellois children at sixty-six months after in utero exposure to methylmercury from a maternal fish diet: pilot study. Neurotoxicol 16(4):639-652.
55. Myers GJ, Davidson PW, Cox C, Shamlaye C, Tanner M, Marsh DO, et al. 1995d. Summary of the Seychelles Child Development Study on the relationship of fetal methylmercury exposure to neurodevelopment. Neurotoxicology 16(4):711-716.
56. Myers GJ, Davidson PW, Palumbo D, Shamlaye C, Cox C, Cernichiari E, et al. 2000. Secondary analysis from the Seychelles Child Development Study: the Child Behaviour Checklist Environ Res 84:12-19.
57. Myers GJ, Davidson PW, Shamlaye CF, Axtell CD, Cernichiari E, Choisy O, et al. 1997. Effects of prenatal methylmercury exposure from a high fish diet on developmental milestones in the Seychelles Child Development Study. Neurotoxicology 180(3):819-830.
58. Myers GJ, Marsh DO, Cox C, Davidson PW, Shamlaye C, Tanner M, et al. 1995a, A pilot neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet. Neurotoxicology 16(4):629-638.
59. Myers GJ, Marsh DO, Davidson PW, Cox C, Shamlaye C, Tanner M, et al. 1995c. Main neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: outcome at six months. Neurotoxicology 16(4):653-664.
60. NRC (National Research Council). 2000. Toxicological Effects of Mercury. Washington, DC:National Academy Press.
61. Neisser U, Boodoo G, Bouchard TJ, Boykin AW, Brody N, Ceci SJ, et al. 1996. intelligence: knowns and unknowns. Am Psychol 51:77-101.
62. Office of Environmental Health Assessment Services. 1999. Evaluation of Evidence Related to the Development of a Tolerable Daily intake for Methylmercury. Olympia, WA:State Department of Health. Available: http://www.doh.wa.gov/ehp/oehas/default.htm [accessed 26 November 2005].
63. Palumbo DR, Cox C, Davidson PW, Myers GJ, Choi A, Shamlaye C, et al. 2000. Association between prenatal exposure to methylmercury and cognitive functioning in Seychellois children: a reanalysis of the McCarthy scales of children's ability from the main cohort study, Environ Res 84:81-88.
64. Rice DC, Schoeny R, Mahaffey K. 2003. Methods and rationale for derivation of a reference dose for methylmercury by the USA EPA. Risk Anal 23(1):107-115.
65. Shamlaye CF, Marsh DO, Myers GJ, Cox C, Davidson PW, Choisy O, et al. 1995. The Seychelles child development study on neurodevelopmental outcomes in children following in utero exposure to methylmercury from a maternal fish diet: background and demographics. Neurotoxicology 16(4):597-612.
66. Smith AP. 1992. Time of day and performance. In: Handbook of Human Performance Vol 3. State and Trait. (Smith AP, Jones DM, eds). London:Academic Press.
67. Spurgeon A. 2002. Review of the Literature Relating to the Chronic Neurobehavioural Effects of Occupational Exposure to Organic Solvents. London, UK:U.K. Industrial Injuries Advisory Council. Available: www.iiac.org.uk/reports.shtml [accessed 26 November 2005.
68. Spurgeon A. 1996, The use of neurobehavioural test batteries for research, diagnosis and screening. Methodological aspects. Toxicol Lett 82/83:191-195.
69. Spurgeon A, Gamberale F. 1997. Occupational Exposure Limits. Key Document. Criteria for the Qualitative Evaluation of Human Neurobehavioural Studies of Neurotoxicity. European Commission. Report EUR 17390 EN. Luxembourg: Office for Official Publications of the European Community.
70. Stephens R, Barker P. 1998, Role of human neurobehavioral tests in regulatory activity on chemicals. Occup Environ Med 55(3):210-214.
71. Stern AH, Gochfeld M. 1999. Letter to the Editor. JAMA 281(10):896.
72. Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, et al. 2000. Maternal seafood diet, methylmercury exposure and neonatal neurologic function. J Pediatr 136(5):599-605.
73. Stewert PW, Reihman J, Lonky El, Darvill TJ, Pagano J. 2003. Cognitive development in preschool children prenatally exposed to PCBs and MeHg. Neurotoxicol Teratol 25(1):11-22
74. Stollery BT. 1985. Psychological toxicology: new methods for detecting sub-clinical effects. In: Environmental Health 3: Neurobehavioral Methods in Environmental and Occupational Health. Copenhagan:World Health Organization Publications 80-85.
75. Stollery BT. 1990. Measuring marginal toxicity in work environments. In: Microcomputers, Psychology and Medicine (West R, Christie M, Weinman J, eds). London:John Wiley and Son, 97-115.
76. Stollery BT. 1996. Cognitive neurotoxicology: a luxury or necessity? Neurotoxicol Teratol 18(4):359-364.
77. Trask CL, Kosofsky BE. 2000. Developmental considerations of neurotoxic exposures. Clin Neurobehav Toxicol 18(3): 541-561.
78. Wechsler D. 1991. Wechsler Intelligence Scale for Children III. New York:The Psychological Corporation.
79. Weihe P, Grandjean P, Debes F, White RF. 1996. Health implications for Faroe islanders of heavy metals and PCBs from pilot whales. Sci Total Environ 186:141-148.
80. Weihe P, Hansen J, Murata K, Debes F, Jorgensen PJ, Steuerwald U, et al. 2002, Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury. Int J Circumpolar Health 61:41-49.
81. World Health Organization. 1989. Solvents and the Central Nervous System. Environmental Health Series No 36. Copenhagen:World Health Organization.
82. Williamson AM. 1990, The development of a neurobehavioral test battery for use in hazard evaluations in occupational settings. Neurotoxicol Teratol 12:509-514.