Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 1, 2007, Pages 378-384

  Madejczyk, Michael S ^a   Aremu, David A ^a   Simmons Willis, Tracey A ^b   Clarkson, Thomas W ^a   Ballatori, Nazzareno ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b TEXAS SOUTHERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIDOTE; CYSTEINE; METHYLMERCURY; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL MEMBRANE; DRUG TRANSPORT; FEMALE; HYPOTHESIS; KIDNEY TUBULE; LIQUID; LIVER; MALE; MEMBRANE VESICLE; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RAT; URINARY EXCRETION; WILD TYPE; WISTAR RAT;

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIDOTES; ATP-BINDING CASSETTE TRANSPORTERS; CELL MEMBRANE; FEMALE; LIVER; MALE; METHYLMERCURY COMPOUNDS; RATS; RATS, WISTAR;

EID: 34250693618     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.122812     Document Type: Article

References (35)

1. Al-Abbasi AH, Kostyniak PJ, and Clarkson TW (1978) An extracorporeal complexing hemodialysis system for the treatment of methylmercury poisoning: III. Clinical Applications. J Pharmacol Exp Ther 207:249-254.
2. Aposhian HV, Maiorino RM, Gonzalez-Ramirez D, Zuniga-Charles M, Xu Z, Hurlbut KM, Junco-Munoz P, Dart RC, and Aposhian MM (1995) Mobilization of heavy metals by newer, therapeutically useful chelating agents. Toxicology 97:23-38.
3. Ballatori N (1994) Glutathione mercaptides as transport forms of metals. Adv Pharmacol 27:271-298.
4. Ballatori N (2002) Transport of toxic metals by molecular mimicry. Environ Health Perspect 110:689-694.
5. Ballatori N, Lieberman MW, and Wang W (1998a) N-acetylcysteine as an antidote in methylmercury poisoning. Environ Health Perspect 106:267-271.
6. Ballatori N, Lieberman MW, and Wang W (1998b) Accelerated methylmercury elimination in γ-glutamyl transpeptidase-deficient mice. Am J Pathol 152:1049-1055.
7. Ballatori N, Moseley RH, and Boyer JL (1986) Sodium-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes: studies in rat liver sinusoidal and canalicular membrane vesicles. J Biol Chem 261:6216-6221.
8. Blitzer BL and Donovan CB (1984) A new method for the rapid isolation of basolateral plasma membrane vesicles from rat liver. J Biol Chem 259:9295-9301.
9. Borgström L, Kagedal B, and Paulsen O (1986) Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol 31:217-222.
10. Borst P, Evers R, Kool M, and Wijnholds J (2000) A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92:1295-1302.
11. 0,+ and the transport of thiol-S-conjugates of methylmercury. J Pharmacol Exp Ther 319:948-956.
12. Buist SC, Cherrington NJ, Choudhuri S, Hartley DP, and Klaassen CD (2002) Gender-specific and developmental influences on the expression of rat organic anion transporters. J Pharmacol Exp Ther 301:145-151.
13. Chen C, Slitt AL, Dieter MZ, Tanaka Y, Scheffer GL, and Klassen CD (2005) Up-regulation of MRP4 expression in kidney of Mrp2-deficient TR- rats. Biochem Pharmacol 60:1088-1095.
14. Clarkson TW (1972) The pharmacology of mercury compounds. Annu Rev Pharmacol 12:375-406.
15. Clarkson TW (2002) The three modern faces of mercury. Environ Health Perspect 110:11-23.
16. Clarkson TW, Magos L, Cox C, Greenwood MR, Amin-Zaki L, Majeed MA, and Al-Damluji SF (1981) Tests of efficacy of antidotes for removal of methylmercury in human poisoning during the Iraq outbreak. J Pharmacol Exp Ther 218:74-83.
17. Clarkson TW, Small H, and Norseth T (1973) Excretion and absorption of methyl mercury after polythiol resin treatment. Arch Environ Health 26:l73-l76.
18. Elhassani SB (1982) The many faces of methylmercury poisoning. J Toxicol Clin Toxicol 19:875-906.
19. Friberg L and Mottet NK (1989) Accumulation of methylmercury and inorganic mercury in the brain. Biol Trace Elem Res 21:201-206.
20. Koh AS, Simmons-Willis TA, Pritchard JB, Grassl SM, and Ballatori N (2002) Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1, Oat1. Mol Pharmacol 62:921-926.
21. Kruh GD and Belinsky MG (2003) The MRP family of drug efflux pumps. Oncogene 22:7537-7552.
22. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
23. Lund ME, Clarkson TW, and Berlin M (1984) Treatment of acute methylmercury ingestion by hemodialysis with N-acetylcysteine (Mucomyst) infusion and 2,3-dimercaptopropane sulfonate. Clin Toxicol 22:31-49.
24. Maher JM, Slitt AL, Cherrington NJ, Cheng X, and Klaassen CD (2005) Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos 33:947-955.
25. Meier PJ, St Meier-Abt A, Barrett C, and Boyer JL (1984) Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles: evidence for an electrogenic canalicular organic anion carrier. J Biol Chem 259:10614-10622.
26. Norseth T and Clarkson TW (l970) Studies on the biotransformation of 203Hg-labeled methylmercury chloride in rats. Arch Environ Health 21:717-727.
27. Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, Scheffer GL, Scheper RJ, Borst P, and Oude Elferink RP (1996) Congenital jaundice in rats with a mutation in multidrug resistance-associated protein gene. Science 271:1126-1128.
28. Schaub TP, Kartenbeck J, Konig J, Vogel O, Witzgall R, Kriz W, and Keppler D (1997) Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol 8:1213-1221.
29. Sekine T, Cha SH, and Endou H (2000) The multispecific organic anion transporter (OAT) family. Pflugers Arch 440:337-350.
30. Simmons-Willis TA, Koh AS, Clarkson TW, and Ballatori N (2002) Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino transporter (LAT)-1 and LAT2. Biochem J 367:239-246.
31. Smith DJ and Ploch SA (1991) Isolation of Raja erinacea basolateral liver plasma membranes: characterization of lipid composition and fluidity. J Exp Zool 258:189-195.
32. Sweet DH, Wolff NA, and Pritchard JB (1997) Expression cloning and characterization of ROAT1: the basolateral organic anion transporter in rat kidney. J Biol Chem 272:30088-30095.
33. Tojo A, Sekine T, Nakajima N, Hosoyamada M, Kanai Y, Kimura K, and Endou H (1999) Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10:464-471.
34. Uwai Y, Okuda M, Takami K, Hashimoto Y, and Inui K (1998) Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett 438:321-324.
35. Zalups RK and Ahmed S (2005) Transport of N-acetylcysteine S-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with organic anion transporter 1. J Pharmacol Exp Ther 314:1158-1168.